Publications
All peer reviewed publications are listed below.
Displaying page 7 of 24.
Effects of cannabis on lung function: a population-based cohort study | 2010
Hancox, R. J. , Poulton, R., Ely,
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European Respiratory Journal, 2010, 35(35), 42-47.
Our ref: RO594
The effects of cannabis on lung function remain unclear and may be different to tobacco. We compared the associations between use of these substances and lung function in a population-based cohort (n=1037). Cannabis and tobacco use were reported at ages 18, 21, 26, and 32 years. Spirometry, plethysmography, and carbon monoxide transfer factor were measured at age 32. Associations between lung function and exposure to each substance were adjusted for exposure to the other substance. Cumulative cannabis use was associated with higher forced vital capacity, total lung capacity, functional residual capacity, and residual volume. Cannabis was also associated with higher airways resistance but not with forced expiratory volume in 1 second, forced expiratory ratio, or transfer factor. These findings were similar amongst those who did not smoke tobacco. By contrast, tobacco use was associated with lower forced expiratory volume in 1 second, lower forced expiratory ratio, lower transfer factor, and higher static lung volumes, but not with airways resistance. Cannabis appears to have different effects on lung function to those of tobacco. Cannabis use was associated with higher lung volumes suggesting hyperinflation and increased large-airways resistance, but there was little evidence for airflow obstruction or impairment of gas transfer.
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How common are common mental disorders? Evidence that lifetime prevalence rates are doubled by prospective versus retrospective ascertainment | 2010
Moffitt, T.E., Caspi, A., Taylor,
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Psychological Medicine, 2010, 40(40), 899-909.
doi:10.1017/S0033291709991036
Our ref: RO589
BACKGROUND: Most information about the lifetime prevalence of mental disorders comes from retrospective surveys, but how much these surveys have undercounted due to recall failure is unknown. We compared results from a prospective study with those from retrospective studies.MethodThe representative 1972-1973 Dunedin New Zealand birth cohort (n=1037) was followed to age 32 years with 96% retention, and compared to the national New Zealand Mental Health Survey (NZMHS) and two US National Comorbidity Surveys (NCS and NCS-R). Measures were research diagnoses of anxiety, depression, alcohol dependence and cannabis dependence from ages 18 to 32 years. RESULTS: The prevalence of lifetime disorder to age 32 was approximately doubled in prospective as compared to retrospective data for all four disorder types. Moreover, across disorders, prospective measurement yielded a mean past-year-to-lifetime ratio of 38% whereas retrospective measurement yielded higher mean past-year-to-lifetime ratios of 57% (NZMHS, NCS-R) and 65% (NCS). CONCLUSIONS: Prospective longitudinal studies complement retrospective surveys by providing unique information about lifetime prevalence. The experience of at least one episode of DSM-defined disorder during a lifetime may be far more common in the population than previously thought. Research should ask what this means for etiological theory, construct validity of the DSM approach, public perception of stigma, estimates of the burden of disease and public health policy.
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Adverse childhood experiences and adult risk factors for age-related disease: depression, inflammation, and clustering of metabolic risk markers | 2009
Danese, A. , Moffitt, T. E. , Harrington,
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Archives of Pediatrics & Adolescent Medicine, 2009, 163(163), 1135-1143.
Link to full publication »
Our ref: RO593
OBJECTIVE: To understand why children exposed to adverse psychosocial experiences are at elevated risk for age-related disease, such as cardiovascular disease, by testing whether adverse childhood experiences predict enduring abnormalities in stress-sensitive biological systems, namely, the nervous, immune, and endocrine/metabolic systems. DESIGN: A 32-year prospective longitudinal study of a representative birth cohort. SETTING: New Zealand. PARTICIPANTS: A total of 1037 members of the Dunedin Multidisciplinary Health and Development Study. Main Exposures During their first decade of life, study members were assessed for exposure to 3 adverse psychosocial experiences: socioeconomic disadvantage, maltreatment, and social isolation. MAIN OUTCOME MEASURES: At age 32 years, study members were assessed for the presence of 3 age-related-disease risks: major depression, high inflammation levels (high-sensitivity C-reactive protein level >3 mg/L), and the clustering of metabolic risk biomarkers (overweight, high blood pressure, high total cholesterol, low high-density lipoprotein cholesterol, high glycated hemoglobin, and low maximum oxygen consumption levels. RESULTS: Children exposed to adverse psychosocial experiences were at elevated risk of depression, high inflammation levels, and clustering of metabolic risk markers. Children who had experienced socioeconomic disadvantage (incidence rate ratio, 1.89; 95% confidence interval, 1.36-2.62), maltreatment (1.81; 1.38-2.38), or social isolation (1.87; 1.38-2.51) had elevated age-related-disease risks in adulthood. The effects of adverse childhood experiences on age-related-disease risks in adulthood were nonredundant, cumulative, and independent of the influence of established developmental and concurrent risk factors. CONCLUSIONS: Children exposed to adverse psychosocial experiences have enduring emotional, immune, and metabolic abnormalities that contribute to explaining their elevated risk for age-related disease. The promotion of healthy psychosocial experiences for children is a necessary and potentially cost-effective target for the prevention of age-related disease.
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Researching genetic versus nongenetic determinants of disease: A comparison and proposed unification | 2009
Ioannidis, J.P.A., Loy, E.Y., Poulton,
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Science Translational Medicine, 2009, 1(1), 7ps8.
doi: 10.1126/scitranslmed.3000247
Our ref: RO592.2
Research standards deviate in genetic versus nongenetic epidemiology. Besides some immutable differences, such as the correlation pattern between variables, these divergent research standards can converge considerably. Current research designs that dissociate genetic and nongenetic measurements are reaching their limits. Studies are needed that massively measure genotypes, nongenetic exposures, and outcomes concurrently.
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Accelerated decline in lung function in cigarette smokers is associated with TP53/MDM2 polymorphisms | 2009
Hancox, R. J. , Poulton, R. , Welch,
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Human Genetics, 2009, 126(126), 559-565.
www.ncbi.nlm.nih.gov/pubmed/19521721/1432-1203 (Electronic)
Our ref: RO592
In vitro studies have shown that p53 mediates a protective response against DNA damage by causing either cell-cycle arrest and DNA repair, or apoptosis. These responses have not yet been demonstrated in humans. A common source of DNA damage in humans is cigarette smoke, which should activate p53 repair mechanisms. As the level of p53 is regulated by MDM2, which targets p53 for degradation, the G-allele of a polymorphism in intron 1 of MDM2 (rs2279744:G/T), that results in higher MDM2 levels, should be associated with a reduced p53 response and hence more DNA damage and corresponding tissue destruction. Similarly, the alleles of rs1042522 in TP53 that encode arginine (G-allele) or proline (C-allele) at codon 72, which cause increased pro-apoptotic (G-allele) or cell-cycle arrest activities (C-allele), respectively, may moderate p53's ability to prevent DNA damage. To test these hypotheses, we examined lung function in relation to cumulative history of smoking in a population-based cohort. The G-alleles in MDM2 and TP53 were found to be associated with accelerated smoking-related decline in lung function. These data support the hypothesis that p53 protects from DNA damage in humans and provides a potential explanation for the variation in lung function impairment amongst smokers.
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Cats and dogs and the risk of atopy in childhood and adulthood | 2009
Mandhane, P. J., Sears, M.R., Poulton,
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Journal of Allergy and Clinical Immunology, 2009, 124(124), 745-750.e4.
www.ncbi.nlm.nih.gov/pubmed/19703709
Our ref: RO591
BACKGROUND: Exposure to cats and dogs during childhood has been linked to a lower risk of developing allergies. It remains unclear whether this is due to selective avoidance of pets by families with a history of allergies. The effects of pet ownership in adulthood are unknown. OBJECTIVES: We sought to assess the association between cat and dog ownership in childhood and early adulthood and the development of atopy in a population-based birth cohort of 1037 subjects. METHODS: Ownership of cats or dogs between birth and age 9 years and between the ages of 18 and 32 years was reported. Skin prick tests to common allergens were performed at 13 and 32 years. RESULTS: There was no evidence that families with a history of atopy avoided owning pets. There were significant cat-by-dog interactions for the development of atopy in both childhood and adulthood. Children who had owned both a cat and a dog were less likely to be atopic at age 13 years. Living with only one of these animals was not protective against atopy. Among those who were not atopic by age 13 years, having both a cat and a dog in adulthood was associated with a lower risk of new atopy by age 32 years. This association was only significant among those with a parental history of atopy. These effects were independent of a range of potential confounding factors. CONCLUSIONS: There is a synergistic interaction between cat and dog exposure that is associated with a lower risk of developing atopy in childhood and young adulthood.
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Protective effect of CHHR1 gene variants on the development of adult depression following childhood maltreatment: Replication and extension | 2009
Polanczyk, G., Caspi, A., Williams,
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Archives of General Psychiatry, 2009, 66(66), 978-985.
Link to full publication »
Our ref: RO590
Context A previous study reported a genexenvironment interaction in which a haplotype in the corticotropin-releasing hormone receptor 1 gene (CRHR1) was associated with protection against adult depressive symptoms in individuals who were maltreated as children (as assessed by the Childhood Trauma Questionnaire [CTQ]). Objective To replicate the interaction between childhood maltreatment and a TAT haplotype formed by rs7209436, rs110402, and rs242924 in CRHR1, predicting adult depression. Design Two prospective longitudinal cohort studies. Setting England and New Zealand. Participants Participants in the first sample were women in the E-Risk Study (N=1116), followed up to age 40 years with 96% retention. Participants in the second sample were men and women in the Dunedin Study (N=1037), followed up to age 32 years with 96% retention. Main Outcome Measure Research diagnoses of past-year and recurrent major depressive disorder. Results In the E-Risk Study, the TAT haplotype was associated with a significant protective effect. In this effect, women who reported childhood maltreatment on the CTQ were protected against depression. In the Dunedin Study, which used a different type of measure of maltreatment, this finding was not replicated. Conclusions A haplotype in CRHR1 has been suggested to exert a protective effect against adult depression among research participants who reported maltreatment on the CTQ, a measure that elicits emotional memories. This suggests the hypothesis that CRHR1's protective effect may relate to its function in the consolidation of memories of emotionally arousing experiences.
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Childhood neuropsychological deficits associated with adult obsessive-compulsive disorder | 2009
Grisham, J. R. , Anderson, T. M. , Poulton,
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British Journal of Psychiatry, 2009, 195(195), 138-141.
Link to full publication »
Our ref: RO587
BACKGROUND: Existing neuropsychological studies of obsessive-compulsive disorder (OCD) are cross-sectional and do not provide evidence of whether deficits are trait-related (antecedent and independent of symptomatology) or state-related (a consequence, dependent on symptomatology). AIMS: To investigate whether there are premorbid neuropsychological deficits associated with adult OCD. METHOD: Longitudinal data were collected from participants of the Dunedin Multidisciplinary Health and Developmental study. Neuropsychological data collected at age 13 were linked with age 32 diagnosis of OCD. RESULTS: The group who had OCD at age 32 differed significantly from the control group with no OCD on their performance at age 13 on neuropsychological tests of visuospatial, visuoconstructive and visuomotor skills, controlling for gender and socioeconomic status, but did not differ on tests of general IQ or verbal ability. Performance of the group with OCD on tests of executive functioning was mixed. CONCLUSIONS: Individuals with OCD have premorbid impairment in visuospatial abilities and some forms of executive functioning, consistent with biological models of OCD.
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Leptin, adiponectin and asthma: findings from a population-based cohort study | 2009
Sutherland, T.J.T., Taylor, D.R. , Sears,
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Annals of Allergy, Asthma & Immunology, 2009, 103(103), 101-107.
Our ref: RO586
Background: Obesity is thought to increase the risk of asthma, especially in women. It has been proposed that this association could be due to the immune-modulating effect of adipokines secreted by adipose tissue. Objective: To investigate whether aspects of the asthma phenotype are associated with higher levels of the proinflammatory adipokine leptin and lower levels of the anti-inflammatory adipokine adiponectin in a cross-sectional analysis of a group of young adults. Methods: Associations between leptin and adiponectin and a diagnosis of asthma, symptoms of wheeze, bronchodilator response, airflow obstruction, and exhaled nitric oxide were evaluated by logistic or linear regression in a population-based birth cohort of approximately 1,000 men and women aged 32 years. Further analyses adjusted for smoking and body fat. Results: There were no significant associations between leptin and any of the markers of the asthma phenotype in either men or women. In men, higher levels of adiponectin were associated with lower levels of exhaled nitric oxide but an increased risk of bronchodilator responsiveness. The inverse association with exhaled nitric oxide remained significant after adjustment for body fat, but the association with bronchodilator responsiveness did not. Adiponectin levels were not associated with any markers of asthma in women. Conclusions: The inverse association between adiponectin and exhaled nitric oxide in men warrants further investigation. However, the findings indicate that levels of leptin and adiponectin are unlikely to mediate the previously observed association between obesity and asthma.
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Predictive value of family history on severity of illness: the case for depression, anxiety, alcohol dependence, and drug dependence | 2009
Milne, B. J. , Caspi, A. , Harrington,
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Archives of General Psychiatry, 2009, 66(66), 738-47.
Link to full publication »
Our ref: RO585
CONTEXT: If family history is associated with clinical features that are thought to index seriousness of disorder, this could inform clinicians predicting patients' prognosis and researchers selecting cases for genetic studies. Although tests of associations between family history and clinical features are numerous for depression, such tests are relatively lacking for other disorders. OBJECTIVE: To test the hypothesis that family history is associated with 4 clinical indexes of disorder (recurrence, impairment, service use, and age at onset) in relation to 4 psychiatric disorders (major depressive episode, anxiety disorder, alcohol dependence, and drug dependence). DESIGN: Prospective longitudinal cohort study. SETTING: New Zealand. PARTICIPANTS: A total of 981 members of the 1972 to 1973 Dunedin Study birth cohort (96% retention). MAIN OUTCOME MEASURES: For each disorder, family history scores were calculated as the proportion of affected family members from data on 3 generations of the participants' families. Data collected prospectively at the study's repeated assessments (ages 11-32 years) were used to assess recurrence, impairment, and age at onset; data collected by means of a life history calendar at age 32 years were used to assess service use. RESULTS: Family history was associated with the presence of all 4 disorder types. In addition, family history was associated with a more recurrent course for all 4 disorders (but not significantly for women with depression), worse impairment, and greater service use. Family history was not associated with younger age at onset for any disorder. CONCLUSIONS: Associations between family history of a disorder and clinical features of that disorder in probands showed consistent direction of effects across depression, anxiety disorder, alcohol dependence, and drug dependence. For these disorder types, family history is useful for determining patients' clinical prognosis and for selecting cases for genetic studies.
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Trajectories of dental anxiety in a birth cohort | 2009
Thomson, W. M. , Broadbent, J. M. , Locker,
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Community Dentistry and Oral Epidemiology, 2009, 37(37), 209-219.
www.ncbi.nlm.nih.gov/pubmed/19508269
Link to full publication »
Our ref: RO584
OBJECTIVE: To examine predictors of dental anxiety trajectories in a longitudinal study of New Zealanders. METHODS: Prospective study of a complete birth cohort born in 1972/73 in Dunedin, New Zealand, with dental anxiety scale (DAS) scores and dental utilization determined at ages 15, 18, 26 and 32 years. Personality traits were assessed at a superfactor and (more fine-grained) subscale level via the Multidimensional Personality Questionnaire at age 18 years. Group-based trajectory analysis was used to identify dental anxiety trajectories. RESULTS: DAS scores from at least three assessments were available for 828 participants. Six dental anxiety trajectories were observed: stable nonanxious low (39.6%); stable nonanxious medium (37.9%); recovery (1.6%); adult-onset anxious (7.7%); stable anxious (7.2%) and adolescent-onset anxious (5.9%). Multivariate analysis showed that males and those with higher DMFS at age 15 years were more likely to be in the stable nonanxious low trajectory group. Membership of the stable nonanxious medium group was predicted by the dental caries experience at age 15 years. Participants who had lost one or more teeth between ages 26 and 32 years had almost twice the relative risk for membership of the adult-onset anxious group. Personality traits predicted group membership. Specifically, high scorers (via median split) on the 'stress reaction' subscale had over twice the risk of being in the stable anxious group; low scorers on the traditionalism subscale were more likely to be members of the recovery trajectory group; and high scorers on the 'social closeness' subscale had half the risk of being in the stable anxious group. Dental caries experience at age 5 years was also a predictor for the stable anxious group. Membership of the late-adolescent-onset anxious group was predicted by higher dental caries experience by age 15 years, but none of the other predictors was significant. CONCLUSION: Six discrete trajectories of dental anxiety have been observed. Some trajectories (totalling more than 90% of the cohort) had clear associations with external influences, but others were more strongly associated with characteristics such as personality traits. A mix of both influences was observed with only the stable anxious dental anxiety trajectory.
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Personality influences on change in smoking behaviour | 2009
Welch, D., Poulton, R.
Health Psychology, 2009, 28(28), 292-299.
10.1037/a0013471
Link to full publication »
Our ref: RO583
Objective: To investigate associations between personality traits in early adulthood (and changes in them) and change in smoking status. Design: Prospective, longitudinal study of a general-population birth cohort. Main Outcome Measures: We measured smoking at ages 18, 26, and 32, and personality at ages 18 and 26 using the Multidimensional Personality Questionnaire (Tellegen & Waller, in press). We assessed personality's ability to predict future smoking, and assessed how changes in personality traits relate to change in smoking status. Results: Higher aggression and alienation at age 18 predicted smoking at 26; higher self-control and traditionalism at age 18 predicted nonsmoking at 26; and higher alienation at age 26 predicted persistence of smoking to age 32. Personality change between 18 and 26 was associated with change in smoking behavior; those who stopped smoking decreased more than others in negative emotionality and increased more in constraint. Conclusion: These findings suggest that interventions fostering personality change may be effective in reducing smoking and indicate appropriate targets for such antismoking interventions in young people. In particular, high alienation predicted smoking persistence, perhaps due to resistance to existing antismoking messages; we discuss approaches that may overcome this.
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Child sexual abuse and persistence of risky sexual behaviours and negative sexual outcomes over adulthood: findings from a birth cohort. | 2009
van Roode, T., Dickson, N., Herbison,
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Child Abuse and Neglect, 2009, 33(33), 161-172.
Our ref: RO582
OBJECTIVES: To determine the impact of child sexual abuse (CSA) on adult sexual behaviors and outcomes over three age periods. METHODS: A longitudinal study of a birth cohort born in Dunedin, New Zealand in 1972/1973 was used. Information on CSA was sought at age 26, and on sexual behaviors and outcomes at ages 21, 26, and 32. Comparisons were over the whole period from age 18 to 32, then for the three age periods from age 18 to 21, 21 to 26, and 26 to 32, adjusting for measures of family environment. RESULTS: Overall, 465 women and 471 men (91.9% of the surviving cohort) answered questions about CSA. Contact CSA was reported by 30.3% of women and 9.1% of men. For abused women, significantly increased rates were observed for number of sexual partners, unhappy pregnancies, abortion, and sexually transmitted infections from age 18 to 21; with rates approaching those of nonabused over time. Conversely, for abused men rates were not significantly elevated in the youngest age period, but were for number of partners from age 26 to 32 and acquisition of herpes simplex virus type 2 from age 21 to 32. CONCLUSIONS: Gender and age are critical when considering the effect of CSA. While the profound early impact of CSA demonstrated for women appears to lessen with age, abused men appear to carry increased risks into adulthood. PRACTICE IMPLICATIONS: CSA is common and should be considered when young women present with unwanted conceptions or seek multiple terminations, and when men continue to have high risk sexual behavior into adulthood. Furthermore, if CSA is disclosed, sexual risks in adulthood need to be considered.
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Sleep problems in childhood predict neuropsychological functioning in adolescence | 2009
Gregory, A. M. , Caspi, A., Moffitt,
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Pediatrics, 2009, 123(123), 1171-1176.
Link to full publication »
Our ref: RO581
OBJECTIVES: Our goal was to examine the association between parent-rated sleep problems during childhood and neuropsychological functioning during adolescence. PARTICIPANTS AND METHODS: Longitudinal prospective data on an entire birth cohort from Dunedin, New Zealand, were obtained. One thousand thirty-seven children were enrolled in the study (52% male). Parents reported on sleep problems when the study members were 5, 7, and 9 years of age. Neuropsychological functioning was assessed by using 7 tests when the participants were 13 years of age. RESULTS: After adjusting for gender and socioeconomic status, persistent sleep problems during childhood predicted scores on 2 neuropsychological tests: the copy score of the Rey-Osterrieth Complex Figure Test and 2 measures of performance on the Halstead Trail Making Test. These results were substantively replicated when sleep was assessed at the 5- and 9-year (but not 7-year) assessments separately. CONCLUSIONS: Sleep problems during childhood may be associated with certain aspects of neuropsychological functioning during adolescence. This adds to the growing body of literature suggesting that childhood sleep problems may be a risk indicator of later difficulties.
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An update on cardiovascular disease epidemiology in South East Asia. Rationale and design of the LIFE course study in CARdiovascular disease Epidemiology (LIFECARE) | 2009
Tai, E Shyong , Poulton, R. , Thumboo,
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CVD Prevention & Control, 2009, 4(4), 93-102.
doi:10.1016/j.cvdpc.2009.02.003
Our ref: RO580
The burden of cardiovascular disease (CVD) is likely to increase dramatically in Asia over the next several decades. In this paper, we review the existing data on CVD epidemiology in Asia, with a focus on the INTERHEART study and the Asia Pacific Cohort Studies Collaboration. Existing data suggest that much of CVD may be preventable through reduction in the levels of well-established CVD risk factors. Existing studies in Asia suggest that these findings are likely to be relevant to Asian populations. However, these studies have several important limitations. These include a lack of longitudinal studies with collection of repeated measures of CVD risk factors and the environmental factors that may result in the age-related increase in the levels of these risk factors. As such, the natural history of the development of CVD risk factors such as obesity, diabetes, hypertension and dyslipidemia in Asia, and their relationship in terms of duration and timing of exposure to various environmental influences is currently unknown. In addition, there is a paucity of data related to psychosocial factors that may be involved in the pathogenesis of CVD, either directly or through effects on other CVD risk factors. Finally, little data is available with regards the impact of CVD and its attendant risk factors on health related quality of life and health care utilization. This information is crucial for the design and evaluation of evidence based programs for primary prevention. We have designed a LIFE Course Study in CARdiovascular disease Epidemiology (LIFECARE) involving 12,000 individuals in four South East Asian countries to address these data needs.
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Links between anxiety and allergies: Psychobiological reality or methodological bias? | 2009
Gregory, A. M. , Caspi, A. , Moffitt,
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Journal of Personality, 2009, 77(77), 347-362.
Our ref: RO578
The objective of the study was to examine the link between anxiety and allergies to establish whether it reflects a psychobiological reality or a possible methodological bias. A cohort of 1,037 children enrolled in the study. Anxiety disorders were assessed between 11 and 21 years. Anxious personality was assessed at 18 years. Allergies were examined at 21 years by (a) self reports, (b) skin pricks, and (c) serum total immunoglobulin E (IgE). Self-reported allergies were predicted by recurrent anxiety disorders (OR [95% CI]51.56 [1.062.30], p5.023) and self-reports of anxious personality (OR [95% CI]51.67 [1.172.37], p5.004): Objectively verified allergies were not. These results suggest that the link between anxiety and allergies may reflect a methodological artifact rather than a psychobiological reality.
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Associations between birth weight, early childhood weight gain and adult lung function | 2009
Hancox, R. J. , Poulton, R., Greene,
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Thorax, 2009, 64(64), 228-232.
www.ncbi.nlm.nih.gov/pubmed/19052051
Our ref: RO577
Background. Low birth weight is associated with lower values for spirometry in adults but it is unknown if birth weight influences other measures of pulmonary function. It is also unclear whether post-natal growth affects adult lung function. We assessed the associations between birth weight, post-natal growth and adult lung function in an unselected birth cohort of 1037 children. Methods. Birth weight, weight gain between birth and age 3 years, and lung function at age 32 years were measured. Analyses adjusted for adult height and sex and further adjusted for multiple other potential confounding factors. Results. Birth weight was positively correlated with spirometric (FEV1 and FVC) and plethysmographic (TLC and FRC) lung function and with lung diffusing capacity. These associations persisted after adjustment for confounding factors including adult weight, exposure to cigarette smoke in utero and during childhood, personal smoking, socio-economic status, asthma, and gestational age. Weight gain between birth and age 3 was also positively associated with lung diffusing capacity, and was associated with higher values of lung volumes in men after adjustment for covariates. Neither birth weight nor post-natal weight gain were associated with airflow obstruction. Conclusions. Low birth weight and lower weight gain in early childhood are associated with modest reductions in adult lung function across a broad range of measures of lung volumes and with lower diffusing capacity. These findings are independent of a number of potential confounding factors and support the hypothesis that foetal and infant growth is a determinant of adult lung function.
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Longitudinal study of self-reported sexually transmitted infection incidence by gender and age up to age thirty-two years | 2009
Paul, C., van Roode, T., Herbison,
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Sexually Transmitted Diseases, 2009, 36(36), 63-69.
www.ncbi.nlm.nih.gov/pubmed/18797425
Our ref: RO576
OBJECTIVES: To examine how incidence of self-reported sexually transmitted infections (STIs) varies by gender and age, and the factors that influence this. METHODS: A longitudinal study of a cohort born in Dunedin, New Zealand in 1972/1973. They were questioned about STIs and sexual behavior at age 21, 26, and 32 years (1993-2005). Incidence rates were calculated over 3 age periods and compared using Poisson regression. RESULTS: Of the 1037 members of the original cohort, 92% or more of survivors completed the computer questionnaire at each age. Incidence rates of STIs from first coitus to age 21, age 21 to 26, and age 26 to 32, were 2.0, 3.2, and 2.0 per 100 person-years, respectively for men and 4.4, 3.0, and 1.4 per 100 person-years, respectively for women. After adjustment for sexual behavior, rates for men were elevated from age 21 to 26 compared with first coitus to 21 years of age [incidence rate ratio (IRR) = 1.9, 95% confidence interval (CI) 1.3 to 2.8), but not from age 26 to 32 (IRR = 1.1, 95% CI 0.70-1.9). For women, adjusted rates decreased with age; from 21 to 26 compared with first coitus to 21 (IRR = 0.79, 95% CI 0.56-1.1) and further from 26 to 32 (IRR = 0.39, 95% CI 0.27-0.57). CONCLUSIONS: These unique data, comprising repeated assessment of reported behaviors and STIs in the same population, show that the period before age 21 is a time of special risk for STIs for women and of lower risk for men. The low risk among women aged 26 to 32 years after adjustment for sexual behavior warrants further investigation.
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Male circumcision and serologically determined human papillomavirus infection in a birth cohort | 2009
Dickson, N. P. , Ryding, J. , van Roode,
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Cancer Epidemiology Biomarkers & Prevention, 2009, 18(18), 177-83.
www.ncbi.nlm.nih.gov/pubmed/19124496
Our ref: RO575
Circumcision has been reported to protect against infection with human papillomavirus (HPV) in men, but results have been inconsistent. We followed males in a birth cohort born in Dunedin, New Zealand, in 1972 and 1973 from age 3 to 32 years. Seropositivity at age 32 years for the oncogenic types HPV-16 and 18, and the nononcogenic types 6 and 11, was studied in relation to maternal reports of circumcision status at age 3 for 450 men. Seropositivity to any of these types was associated with lifetime number of sexual partners (P = 0.03), and lower moral-religious emphasis of the family of origin (P < 0.001). Circumcision was not found to be protective, with the adjusted odds ratio (95% confidence interval) for HPV6/11/16/18 seropositivity among the circumcised compared with the uncircumcised being 1.4 (0.89-2.2).
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Obsessions and compulsions in the community: Prevalence, interference, help-seeking, developmental stability and co-occurring psychiatric conditions | 2009
Fullana, M. A. , Mataix-Cols, D. , Caspi,
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American Journal of Psychiatry, 2009, 166(166), 329-336.
Link to full publication »
Our ref: RO574
OBJECTIVE: It is unclear how many people in the community have obsessions and compulsions and associated levels of interference. It is also unknown what variables predict help-seeking for these symptoms, whether they are developmentally stable, and whether they increase the risk of mental disorders. METHOD: The authors analyzed data from the prospective longitudinal Dunedin study of an unselected birth cohort. The presence of obsessions and compulsions and mental disorders was assessed using the Diagnostic Interview Schedule (DIS) at ages 11, 26, and 32. Data on interference and help-seeking were obtained at ages 26 and 32. RESULTS: Obsessions and compulsions were frequent in individuals with mental disorders other than obsessive-compulsive disorder (OCD) and among people without mental disorders. Even in the latter group, these symptoms caused significant interference. The presence of anxiety/depression and of obsessions (particularly aggressive and shameful thoughts), but not compulsions, was associated with help-seeking. Harm/checking was the most prevalent symptom dimension. Symptom dimensions were temporally stable and associated with increased comorbidity. Obsessive-compulsive symptoms at age 11 predicted a high risk of an adult OCD diagnosis as well as elevated adult symptom dimensions. CONCLUSIONS: Obsessions and compulsions are common in the adult population, have their roots in childhood, and are associated with interference, risk for disorders, and help-seeking. Subclinical obsessions and compulsions should be taken into account in research, intervention, and DSM-V.
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Childhood and contemporaneous correlates of adolescent physical inactivity: a longitudinal study | 2009
Richards, R., Poulton, R., Reeder,
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Journal of Adolescent Health, 2009, 44(44), 260-267.
Our ref: RO573
PURPOSE: Although concurrent influences on adolescent physical activity are well documented, longitudinal studies offer additional insights about early life antecedents of participation. The aim of this study was to examine associations between childhood and contemporaneous factors and patterns of physical activity participation during adolescence. METHODS: Physical activity participation at ages 15 and 18 was assessed among members of the Dunedin Multidisciplinary Health and Development Study cohort using the interview-based Minnesota Leisure Time Physical Activity Questionnaire. Logistic regression was used to examine associations between childhood factors (socioeconomic status, family active-recreation orientation, home activities, motor ability, intelligence, and psychiatric disorder), contemporaneous factors (parental health, body mass index, predicted VO(2 max), general health, television viewing, smoking, and alcohol use) and persistent inactivity, declining participation, or persistent activity during adolescence. RESULTS: In multivariate models, persistent inactivity during adolescence was associated with lower childhood family active-recreation orientation, and poorer cardiorespiratory fitness and general health during adolescence. Declining participation was more likely among those who reported fewer activities at home during childhood. Persistent activity was associated with better cardiorespiratory fitness and watching less television during adolescence. CONCLUSIONS: This study found that childhood and contemporaneous factors were associated with persistent inactivity, persistent activity and declining participation during adolescence. The findings highlight several factors from the family and home environment of potential importance in early intervention programs to support adolescent participation in physical activity.
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Patterns of Growth Associated With the Timing of Adiposity Rebound | 2009
Williams, S. M. , Goulding, A.
Obesity, 2009, 17(17), 335-341.
www.ncbi.nlm.nih.gov/pubmed/19057527
Our ref: RO572
This study was undertaken to evaluate the effects of age of adiposity rebound (AR) on measures of fat mass between ages 7 and 11 years, maturity, and adiposity in 458 children from a birth cohort studied to age 26 years. Patterns of growth between ages 3 and 26 years and changes in fat mass index between 7 and 11 years in groups with early (<5.5 years for boys and <5 years for girls), average (between 5.5 and 7.5 years for boys and between 5 and 7 years for girls), and late AR (>/=7.5 years for boys and >/=7 years for girls) are described. The mean z-scores for BMI, height, and weight increased between age 3 years and adolescence in the early-rebound group and decreased in the late-rebound group. The differences were maintained until adulthood for BMI and weight. Disproportionately high increases in fat mass index during growth (7-11 years), more advanced bone age in boys at age 7 years, and earlier menarche in girls were evident in the early-rebound group. The relative risks at 26 years of being overweight (BMI 25-29.9 kg/m(2)) and obese (BMI >/=30 kg/m(2)) were 2.70 (95% confidence interval (CI): 1.55, 4.66) and 5.91 (95% CI: 3.03, 11.55) respectively, using the average group as the reference. The corresponding relative risks for adult waist girths exceeding international cut points were 2.12 (95% CI: 1.09, 4.13) and 3.32 (95% CI: 1.46, 7.54). Thus, early rebound is associated with increased depositions of fat in middle childhood, and risks associated with early rebound persist at least until early adulthood.
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Childhood IQ and adult mental disorders: A test of the cognitive reserve hypothesis | 2009
Koenen, K., Moffitt, T. E. , Roberts,
... Show all »
American Journal of Psychiatry, 2009, 166(166), 50-57.
Link to full publication »
Our ref: RO571
OBJECTIVE: Cognitive reserve has been proposed as important in the etiology of neuropsychiatric disorders. However, tests of the association between premorbid IQ and adult mental disorders other than schizophrenia have been limited and inconclusive. The authors tested the hypothesis that low childhood IQ is associated with increased risk and severity of adult mental disorders. METHOD: Participants were members of a representative 1972'1973 birth cohort of 1,037 males and females in Dunedin, New Zealand, who were followed up to age 32 with 96% retention. WISC-R IQ was assessed at ages 7, 9, and 11. Research diagnoses of DSM mental disorders were made at ages 18, 21, 26, and 32. RESULTS: Lower childhood IQ was associated with increased risk of developing schizophrenia spectrum disorder, adult depression, and adult anxiety. Lower childhood IQ was also associated with greater comorbidity and with persistence of depression; the association with persistence of generalized anxiety disorder was nearly significant. Higher childhood IQ predicted increased risk of adult mania. CONCLUSIONS: Lower cognitive reserve, as reflected by childhood IQ, is an antecedent of several common psychiatric disorders and also predicts persistence and comorbidity. Thus, many patients who seek mental health treatment may have lower cognitive ability; this should be considered in prevention and treatment planning.
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The validity of the Family History Screen for assessing family history of mental disorders | 2009
Milne, B. J. , Caspi, A. , Crump,
... Show all »
American Journal Of Medical Genetics B: Neuropsychiatric Genetics, 2009, 150(150B), 41-49.
Our ref: RO570
There is a need to collect psychiatric family history information quickly and economically (e.g., for genome-wide studies and primary care practice). We sought to evaluate the validity of family history reports using a brief screening instrument, the Family History Screen (FHS). We assessed the validity of parents' reports of seven psychiatric disorders in their adult children probands from the Dunedin Study (n = 959, 52% male), using the proband's diagnosis as the criterion outcome. We also investigated whether there were informant characteristics that enhanced accuracy of reporting or were associated with reporting biases. Using reports from multiple informants, we obtained sensitivities ranging from 31.7% (alcohol dependence) to 60.0% (conduct disorder) and specificities ranging from 76.0% (major depressive episode) to 97.1% (suicide attempt). There was little evidence that any informant characteristics enhanced accuracy of reporting. However, three reporting biases were found: the probability of reporting disorder in the proband was greater for informants with versus without a disorder, for female versus male informants, and for younger versus older informants. We conclude that the FHS is as valid as other family history instruments (e.g., the FH-RDC, FISC), and its brief administration time makes it a cost-effective method for collecting family history data. To avoid biasing results, researchers who aim to compare groups in terms of their family history should ensure that the informants reporting on these groups do not differ in terms of age, sex or personal history of disorder.
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A longitudinal examination of the relationship between adolescent problem behaviors and traffic crash involvement during young adulthood | 2008
Begg, D. J. , Gulliver, P.
Traffic Injury Prevention, 2008, 9(9), 508-14.
doi.org/10.1080/15389580802335117
Link to full publication »
Our ref: RO579
Previous research examining the relationship between adolescent problem behaviors and young adult traffic outcomes (crashes, convictions, risky driving) has produced differing results. Possible reasons for this may be the heterogeneity of the crash outcomes (from minor fender-benders to fatal crashes), the gender of the driver, and/or the age of the driver. The aim of this research was to investigate the relationship between adolescent problem behaviors and young adult crashes to determine the extent to which the above factors influenced this relationship. This study was part of the Dunedin Multidisciplinary Health and Development Study (DMHDS), which is a longitudinal study of a cohort (n = 1,037) born in Dunedin, New Zealand, from April 1972 to March 1973. This cohort has been followed up regularly since birth, and the data for the present research were obtained at the 18-, 21-, and 26-year-old follow-up interviews. The problem behaviors examined were those identified by Jessor in the theory of problem behavior, namely, tobacco smoking, marijuana use, alcohol use, delinquent behavior, and unsafe sexual behavior. Data for these measures were obtained in personal interviews when the cohort was aged 18 years. The self-reported crash data were obtained at the age 21 and age 26 follow-up interviews. Driving exposure, academic qualifications, employment, being a parent, and marital status were included as potential confounders. The results show that involvement in adolescent problem behaviors predicted crash involvement at age 21 for the females but not the males and at age 26 for the males but not the females. Possible explanations for these differences by age and gender are discussed.
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How should we construct psychiatric family history scores? A comparison of alternative approaches from the Dunedin Family Health History Study | 2008
Milne, B.J., Moffitt, T. E. , Crump,
... Show all »
Psychological Medicine, 2008, 38(38), 1793-802.
Our ref: RO569
BACKGROUND: There is increased interest in assessing the family history of psychiatric disorders for both genetic research and public health screening. It is unclear how best to combine family history reports into an overall score. We compare the predictive validity of different family history scores. Method: Probands from the Dunedin Study (n=981, 51% male) had their family history assessed for nine different conditions. We computed four family history scores for each disorder: (1) a simple dichotomous categorization of whether or not probands had any disordered first-degree relatives; (2) the observed number of disordered first-degree relatives; (3) the proportion of first-degree relatives who are disordered; and (4) Reed's score, which expressed the observed number of disordered first-degree relatives in terms of the number expected given the age and sex of each relative. We compared the strength of association between each family history score and probands' disorder outcome. RESULTS: Each score produced significant family history associations for all disorders. The scores that took account of the number of disordered relatives within families (i.e. the observed, proportion, and Reed's scores) produced significantly stronger associations than the dichotomous score for conduct disorder, alcohol dependence and smoking. Taking account of family size (i.e. using the proportion or Reed's score) produced stronger family history associations depending on the prevalence of the disorder among family members. CONCLUSIONS: Dichotomous family history scores can be improved upon by considering the number of disordered relatives in a family and the population prevalence of the disorder.
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Is it important to prevent early exposure to drugs and alcohol among adolescents? | 2008
Odgers, C.L., Caspi, A., Nagin,
... Show all »
Psychological Science, 2008, 19(19), 1037-1044.
Our ref: RO568
Exposure to alcohol and illicit drugs during early adolescence has been associated with poor outcomes in adulthood. However, many adolescents with exposure to these substances also have a history of conduct problems, which raises the question of whether early exposure to alcohol and drugs leads to poor outcomes only for those adolescents who are already at risk. In a 30-year prospective study, we tested whether there was evidence that early substance exposure can be a causal factor for adolescents' future lives. After propensity-score matching, early-exposed adolescents remained at an increased risk for a number of poor outcomes. Approximately 50% of adolescents exposed to alcohol and illicit drugs prior to age 15 had no conduct-problem history, yet were still at an increased risk for adult substance dependence, herpes infection, early pregnancy, and crime. Efforts to reduce or delay early substance exposure may prevent a wide range of adult health problems and should not be restricted to adolescents who are already at risk.
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Childhood sleep-time and long-term risk for obesity: a 32-year prospective birth cohort study | 2008
Landhuis, C.E., Poulton, R., Welch,
... Show all »
Pediatrics, 2008, 122(122), 955-960.
DOI: 10.1542/peds.2007-3521
Our ref: RO567
Context: Associations between short sleep duration and increased body mass index have been found in children and adults. However, it is unknown if short sleep-time during childhood has long-term consequences. We assessed the association between sleep-time in childhood and adult body mass index in a birth cohort. Methods: Study members were a general population birth cohort of 1037 participants (502 female) were born in Dunedin, New Zealand, between April 1972 and March 1973. Parental reports of bed and rising times collected at ages 5, 7, 9 and 11 years were used to estimate childhood sleep-time. Linear regression was used to analyse the association between childhood sleep-time and body mass index measured at age 32 years. Results: Lower childhood sleep-times were significantly associated with higher adult body mass indices (regression coefficient = -0.99, 95% confidence interval = -1.59 to -0.39, p = 0.001). This association remained after adjustment for adult sleep-time and the potential confounding effects of early childhood body mass index, childhood socioeconomic status, parental body mass indices, child and adult television viewing, adult physical activity and adult smoking (coefficient = -0.93, 95% CI = -1.54 to -0.31, p = 0.003. By logistic regression, more sleep-time during childhood was associated with a lower odds of obesity (OR = 0.73, 95%CI = 0.53 to 1.00, p = 0.051) at age 32 years. This association was significant after adjusting for multiple potential confounding factors (OR = 0.65, 95%CI = 0.43 to 0.97, p = 0.034). Conclusions: These findings suggest that sleep restriction in childhood increases the long-term risk for obesity. Ensuring that children get adequate sleep may be a useful strategy for stemming the current obesity epidemic.
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Gene-environment interactions: A review of epidemiological findings and future directions | 2008
Van Os, J., Rutten, B.P.F., Poulton,
... Show all »
Schizophrenia Bulletin, 2008, 34(34), 1066-82 .
doi:10.1093/schbul/sbn117
Our ref: RO566
Concern is building about high rates of schizophrenia in large cities, and among immigrants, cannabis users, and traumatized individuals, some of which likely reflects the causal influence of environmental exposures. This, in combination with very slow progress in the area of molecular genetics, has generated interest in more complicated models of schizophrenia etiology that explicitly posit gene-environment interactions (EU-GEI. European Network of Schizophrenia Networks for the Study of Gene Environment Interactions. Schizophrenia aetiology: do gene-environment interactions hold the key? [published online ahead of print April 25, 2008] Schizophr Res; S0920-9964(08) 00170-9). Although findings of epidemiological gene-environment interaction (G x E) studies are suggestive of widespread gene-environment interactions in the etiology of schizophrenia, numerous challenges remain. For example, attempts to identify gene-environment interactions cannot be equated with molecular genetic studies with a few putative environmental variables thrown in: G x E is a multidisciplinary exercise involving epidemiology, psychology, psychiatry, neuroscience, neuroimaging, pharmacology, biostatistics, and genetics. Epidemiological G x E studies using indirect measures of genetic risk in genetically sensitive designs have the advantage that they are able to model the net, albeit nonspecific, genetic load. In studies using direct molecular measures of genetic variation, a hypothesis-driven approach postulating synergistic effects between genes and environment impacting on a final common pathway, such as sensitization of mesolimbic dopamine neurotransmission, while simplistic, may provide initial focus and protection against the numerous false-positive and false-negative results that these investigations engender. Experimental ecogenetic approaches with randomized assignment may help to overcome some of the limitations of observational studies and allow for the additional elucidation of underlying mechanisms using a combination of functional enviromics and functional genomics.
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Personality and perception of tinnitus | 2008
Welch, D., Dawes, P. J.
Ear and Hearing, 2008, 29(29), 684-692.
doi: 10.1097/AUD.0b013e318177d9ac
Link to full publication »
Our ref: RO565
OBJECTIVES:: Tinnitus has high prevalence and a wide range of etiologies and of impacts on sufferers. Our objective was to develop understanding of the role of personality in the perception of tinnitus in the general population. As a theoretical basis for this, we combined elements of a general model of signal detection with the ideas of ignition (development) and promotion (neural transmission) of tinnitus, and considered plausible roles for personality factors within this conceptual framework. DESIGN:: We interviewed a birth cohort of 970 people aged 32 yr sampled from the general population. On the basis of questioning, we divided them into three groups, those without tinnitus, those with occasional tinnitus (including those with transient tinnitus of very brief duration), and those who experienced tinnitus most of the time. We also established how annoying or distressing the tinnitus was, and assessed personality using the Multidimensional Personality Questionnaire. RESULTS:: Tinnitus was experienced rarely by 38.2% and half the time or more by 6.8% of those studied. Men and women did not differ in the amount of tinnitus reported, but women were more likely to find it annoying. People from lower socioeconomic backgrounds were more likely to report tinnitus. People with tinnitus were more socially withdrawn, reactive to stress, alienated, and less Self-Controlled. People who were more annoyed by tinnitus were more socially withdrawn, and men were more stress reactive and alienated. CONCLUSIONS:: Our interpretation of the findings is that personality influences the persistence of tinnitus by influencing the tendency to be aware of it. Consideration of personality factors may improve the ability to tailor tinnitus therapies, and the concept of awareness may benefit treatment outcomes by showing tinnitus sufferers a means of internalizing the locus of control over their symptoms.
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Does initial breastfeeding lead to lower blood cholesterol in adult life? A quantitative review of the evidence | 2008
Owen, C. G. , Whincup, P. H. , Kaye,
... Show all »
American Journal of Clinical Nutrition, 2008, 88(88), 305-14.
www.ncbi.nlm.nih.gov/pubmed/18689365
Our ref: RO564
BACKGROUND: Earlier studies have suggested that infant feeding may program long-term changes in cholesterol metabolism. OBJECTIVE: We aimed to examine whether breastfeeding is associated with lower blood cholesterol concentrations in adulthood. DESIGN: The study consisted of a systematic review of published observational studies relating initial infant feeding status to blood cholesterol concentrations in adulthood (ie, aged >16 y). Data were available from 17 studies (17 498 subjects; 12 890 breastfed, 4608 formula-fed). Mean differences in total cholesterol concentrations (breastfed minus formula-fed) were pooled by using fixed-effect models. Effects of adjustment (for age at outcome, socioeconomic position, body mass index, and smoking status) and exclusion (of nonexclusive breast feeders) were examined. RESULTS: Mean total blood cholesterol was lower (P = 0.037) among those ever breastfed than among those fed formula milk (mean difference: -0.04 mmol/L; 95% CI: -0.08, 0.00 mmol/L). The difference in cholesterol between infant feeding groups was larger (P = 0.005) and more consistent in 7 studies that analyzed exclusive feeding patterns (-0.15 mmol/L; -0.23, -0.06 mmol/L) than in 10 studies that analyzed nonexclusive feeding patterns (-0.01 mmol/L; -0.06, 0.03 mmol/L). Adjustment for potential confounders including socioeconomic position, body mass index, and smoking status in adult life had minimal effect on these estimates. CONCLUSIONS: Initial breastfeeding (particularly when exclusive) may be associated with lower blood cholesterol concentrations in later life. Moves to reduce the cholesterol content of formula feeds below those of breast milk should be treated with caution.
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Longitudinal studies to detect gene x environment interactions in common disease - Bang for your buck? A commentary on Chaufan's How much can a large population study on genes, environments, their interactions and common diseases contribute to the health of the American people? (65:8, 1730-1741(2007)) | 2008
Robertson, S.P., Poulton, R.
Social Science and Medicine, 2008, 67(67), 666-672.
www.ncbi.nlm.nih.gov/pubmed/18508172
Our ref: RO562
Invited response to Chaufan, Social Science & Medicine, 2007, 65(8): 1730-1741
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Oral-health-related quality of life in a cohort of 32-year-olds | 2008
Lawrence, H.P., Thomson, W. M. , Broadbent,
... Show all »
Community Dentistry and Oral Epidemiology, 2008, 36(36), 305-316.
doi: 10.1111/j.1600-0528.2007.99395.x
Our ref: RO561
Objectives: To describe oral-health-related quality of life (OHRQoL) among New Zealand adults and assess the relationship between clinical measures of oral health status and a well-established OHRQoL measure, controlling for sex, SES and use of dental services. Methods: A birth cohort of 924 dentate adults (participants in the Dunedin Multidisciplinary Health and Development Study) were systematically examined for dental caries, tooth loss, and periodontal attachment loss (CAL) at age 32 years. OHRQoL was measured using the 14-item Oral Health Impact Profile questionnaire (OHIP-14). The questionnaire also collected data on each study member’s occupation, self-rated oral health and reasons for seeing a dental care provider. SES was determined from each individual’s occupation at age 32 years. Results: The mean total OHIP-14 score was 8.0 (SD 8.1); 23.4% of the cohort reported one or more OHIP problems ‘fairly often’ or ‘very often’. When the prevalence of impacts ‘fairly/very often’ was modeled using Logistic regression, having untreated caries, 2 or more sites with CAL of 4+ mm and 1 or more teeth missing by age 32 remained significantly associated with OHRQoL, after adjusting for sex and ‘episodic’ dental care. Multivariate analysis using Poisson regression determined that being in the low SES group also was associated with the mean number of impacts (extent) and the rated severity of impacts. Conclusions: OHIP-14 scores were significantly associated with clinical oral health status indicators, independently of sex and socio-economic inequalities in oral health. The prevalence of impacts (23.4%) in the cohort was significantly greater than age- and sex-standardised estimates from Australia (18.2%) and the UK (15.9%).
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Programming obesity and poor fitness: the long-term impact of childhood television viewing. Short Communication. | 2008
Landhuis, C.E., Poulton, R., Welch,
... Show all »
Obesity, 2008, 16(16), 1457-1459.
Our ref: RO560
Objective: To assess whether the long-term effects of childhood television viewing on BMI and cardiorespiratory fitness are mediated by adult viewing. Methods and Procedures: This prospective study included an unselected birth cohort of 1,037 participants ( 535 men) born in Dunedin, New Zealand in 1972/1973. Hours of television viewing on weekdays were reported at ages 5, 7, 9, 11, 13, 15, and 32 years. BMI and cardiorespiratory fitness were measured at age 32 years. Results: Both childhood and adult television viewing times were significantly associated with higher BMI and lower cardiorespiratory fitness at age 32 years. Childhood television viewing was a better predictor of adult BMI and fitness than adult viewing and remained a significant predictor of these outcomes after adjusting for adult viewing time. After adjusting for adult viewing, the odds ( 95% confidence interval) of adult obesity increased by a factor of 1.25 ( 1.01, 1.53) and poor fitness increased by a factor of 1.40 ( 1.16, 1.70) for each hour of mean weekday television viewing during childhood. Discussion: The association between childhood television viewing and obesity and poor fitness in adulthood is not mediated by adult viewing. The detrimental health effects of watching too much television during childhood persist into adulthood. Attempts to reduce adult obesity and poor fitness by modifying television viewing habits need to begin in childhood.
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The developmental mental-disorder histories of adults with posttraumatic stress disorder: a prospective longitudinal birth cohort study | 2008
Koenen, K., Moffitt, T. E. , Caspi,
... Show all »
Journal of Abnormal Psychology, 2008, 117(117), 460-466.
Our ref: RO559
Clinical and epidemiologic studies have established that posttraumatic stress disorder (PTSD) is highly comorbid with other mental disorders. However, such studies have largely relied on adults' retrospective reports to ascertain comorbidity. The authors examined the developmental mental health histories of adults with PTSD using data on mental disorders assessed across the first 3 decades of life among members of the longitudinal Dunedin Multidisciplinary Health and Development Study; 100% of those diagnosed with past-year PTSD and 93.5% of those with lifetime PTSD at age 26 had met criteria for another mental disorder between ages 11 and 21. Most other mental disorders had first onsets by age 15. Of new cases of PTSD arising between ages 26 and 32, 96% had a prior mental disorder and 77% had been diagnosed by age 15. These data suggest PTSD almost always develops in the context of other mental disorders. Research on the etiology of PTSD may benefit from taking lifetime developmental patterns of comorbidity into consideration. Juvenile mental-disorder histories may help indicate which individuals are most likely to develop PTSD in populations at high risk of trauma exposure.
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Elevated inflammation levels in depressed adults with a history of childhood maltreatment | 2008
Danese, A. , Moffitt, T. E. , Pariante,
... Show all »
Archives of General Psychiatry, 2008, 65(65), 409-15.
Our ref: RO558
CONTEXT: The association between depression and inflammation is inconsistent across research samples. OBJECTIVE: To test whether a history of childhood maltreatment could identify a subgroup of depressed individuals with elevated inflammation levels, thus helping to explain previous inconsistencies. DESIGN: Prospective longitudinal cohort study. SETTING: New Zealand. PARTICIPANTS: A representative birth cohort of 1000 individuals was followed up to age 32 years as part of the Dunedin Multidisciplinary Health and Development Study. Study members were assessed for history of childhood maltreatment and current depression. MAIN OUTCOME MEASURES: Inflammation was assessed using a clinically relevant categorical measure of high-sensitivity C-reactive protein (>3 mg/L) and a dimensional inflammation factor indexing the shared variance of continuous measures of high-sensitivity C-reactive protein, fibrinogen, and white blood cells. RESULTS: Although depression was associated with high levels of high-sensitivity C-reactive protein (relative risk,1.45; 95% confidence interval,1.06-1.99), this association was significantly attenuated and no longer significant when the effect of childhood maltreatment was taken into account. Individuals with current depression and a history of childhood maltreatment were more likely to have high levels of high-sensitivity C-reactive protein compared with control subjects (n = 27; relative risk, 2.07; 95% confidence interval, 1.23-3.47). In contrast, individuals with current depression only had a nonsignificant elevation in risk (n = 109; relative risk, 1.40; 95% confidence interval, 0.97-2.01). Results were generalizable to the inflammation factor. The elevated inflammation levels in individuals who were both depressed and maltreated were not explained by correlated risk factors such as depression recurrence, low socioeconomic status in childhood or adulthood, poor health, or smoking. CONCLUSIONS: A history of childhood maltreatment contributes to the co-occurrence of depression and inflammation. Information about experiences of childhood maltreatment may help to identify depressed individuals with elevated inflammation levels and, thus, at greater risk of cardiovascular disease.
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Association between frequent headaches, persistent smoking and attempts to quit. | 2008
Waldie, K.E., McGee, R. , Reeder,
... Show all »
Headache, 2008, 48(48), 545-52.
www.ncbi.nlm.nih.gov/pubmed/18218010
Our ref: RO557
Background.—Recent studies have found a strong relationship between tobacco smoking and headache pain. It remains unclear whether smoking behavior leads to headache or visa versa, mainly due to the cross-sectional nature of the majority of this research. Objective.—To help clarify the direction of the relation between smoking and frequent headaches in a representative cohort study. Design and Methods.—Members of the Dunedin Multidisciplinary Health and Development Study (N = 980) were asked about their cigarette smoking and headache history at ages 11 and 13 (childhood), age 15 (mid-adolescence), and age 26 (adulthood). Both cross-sectional and longitudinal associations between smoking and headache status were examined using logistic regression. Results.—During mid-adolescence, the likelihood of frequent headaches doubled for smokers relative to nonsmokers (OR: 2.16, 95% CI: 1.39-3.35). Smoking did not increase the risk of developing headaches in adulthood, however. In contrast, individuals who suffered from frequent headaches during mid-adolescence were 2 times more likely to smoke in adulthood than those without headache (OR: 2.20, 95% CI: 1.3-3.7), after controlling for sex and family socioeconomic status. Attempts to quit smoking were significantly more difficult for migraine sufferers with a history of headache than for those with tension-type headache. Conclusions.—Frequent headaches during mid-adolescence appear to increase the risk of daily smoking in adolescence and adulthood. These individuals also have a more difficult time quitting than their headache-free peers.
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Female and male antisocial trajectories: From childhood origins to adult outcomes | 2008
Odgers, C.L., Caspi, A., Poulton,
... Show all »
Development and Psychopathology, 2008, 20(20), 673-716.
Our ref: RO556
This article reports on the childhood origins and adult outcomes of female versus male antisocial behavior trajectories in the Dunedin longitudinal study. Four antisocial behavior trajectory groups were identified among females and males using general growth mixture modeling and included life-course persistent (LCP), adolescent-onset, childhood-limited, and low trajectory groups. During childhood, both LCP females and males were characterized by social, familial and neurodevelopmental risk factors, whereas those on the adolescent-onset pathway were not. At age 32, women and men on the LCP pathway were engaging in serious violence and experiencing significant mental health, physical health, and economic problems. Females and males on the adolescent-onset pathway were also experiencing difficulties at age 32, although to a lesser extent. Although more males than females followed the LCP trajectory, findings support similarities across gender with respect to developmental trajectories of antisocial behavior and their associated childhood origins and adult consequences. Implications for theory, research, and practice are discussed.
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Gene-environment interaction and the anxiety disorders. Special Issue - Editorial | 2008
Poulton, R., Andrews, G., Millichamp,
... Show all »
European Archives of Psychiatry and Clinical Neuroscience, 2008, 258(258), 65-68.
Link to full publication »
Our ref: RO555
In this Special Issue a number of leading anxiety researchers have critically reviewed attempts to discover replicable gene'environment interactions (G 'E) for the anxiety disorders. They present cogent summaries of what is and what is not known about G ' E for each of the anxiety disorders. They have also identified major stumbling blocks to progress, and offered practical suggestions for overcoming these challenges. Some illustrate strategies for better integrating epidemiological and experimental research to advance understanding. Together, they provide a splendid 'stocktake' of where the field currently is, as well as tantalising us with glimpses of what might be just over the horizon. By way of introduction to this series, we highlight several key issues confronting research seeking to model the complexity of nature'nurture interplay.
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Circumcision and risk of sexually transmitted infections in a birth cohort | 2008
Dickson, N., van Roode, T., Herbison,
... Show all »
Journal of Pediatrics, 2008, 152(152), 383-387.
Our ref: RO554
Objective: To determine the impact of early childhood circumcision on sexually transmitted infection (STI) acquisition to age 32 years. Study design: The circumcision status of a cohort of children born in 1972 and 1973 in Dunedin, New Zealand was sought at age 3 years. Information about STIs was obtained at ages 21, 26, and 32 years. The incidence rates of STI acquisition were calculated, taking into account timing of first sex, and comparisons were made between the circumcised men and uncircumcised men. Adjustments were made for potential socioeconomic and sexual behavior confounding factors where appropriate. Results: Of the 499 men studied, 201 (40.3%) had been circumcised by age 3 years. The circumcised and uncircumcised groups differed little in socioeconomic characteristics and sexual behavior. Overall, up to age 32 years, the incidence rates for all STIs were not statistically significantly different—23.4 and 24.4 per 1000 person-years for the uncircumcised and circumcised men, respectively. This was not affected by adjusting for any of the socioeconomic or sexual behavior characteristics. Conclusions: These findings are consistent with recent population-based cross-sectional studies in developed countries, which found that early childhood circumcision does not markedly reduce the risk of the common STIs in the general population in such countries.
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