Publications
All peer reviewed publications are listed below.
Displaying page 13 of 23.
The respiratory effects of cannabis dependence in young adults | 2000
Taylor, D.R., Poulton, R., Moffitt,
... Show all »
Addiction, 2000, 95(95), 1669-1677.
Our ref: RO364
Aim. To evaluate the relationship between cannabis dependence and respiratory symptoms and lung function in young adults, while controlling for the effects of tobacco smoking. Setting and participants. Nine hundred and forty-three young adults from a birth cohort of 1037 subjects born in Dunedin, New Zealand in 1972/1973 were studied at age 21. Measurements. Standardized respiratory symptom questionnaires were administered. Spirometry and methacholine challenge tests were undertaken. Cannabis dependence was determined using DSM-III-R criteria. Descriptive analyses and comparisons between cannabis-dependent, tobacco-smoking and non-smoking groups were undertaken. Adjusted odds ratios for respiratory symptoms, lung function and airway hyper-responsiveness (PC20) were measured. Findings. Ninety-one subjects (9.7%) were cannabis-dependent and 264 (28.1%) were current tobacco smokers. After controlling for tobacco use, respiratory symptoms associated with cannabis dependence included: wheezing apart from colds, exercise-induced shortness of breath, nocturnal wakening with chest tightness and early morning sputum production. These were increased by 61%, 65%, 72% (all p < 0.05) and 144% (p < 0.01) respectively, compared to non-tobacco smokers. The frequency of respiratory symptoms in cannabis-dependent subjects was similar to tobacco smokers of 1-10 cigarettes/day. The proportion of cannabis-dependent study members with an FEV1/FVC ratio of < 80% was 36% compared to 20% for non-smokers (p = 0.04). These outcomes occurred independently of co-existing bronchial asthma. Conclusion. Significant respiratory symptoms and changes in spirometry occur in cannabis-dependent individuals at age 21 years, even although the cannabis smoking history is of relatively short duration.
« Hide abstract
Children's self-reported psychotic symptoms and adult schizophreniform disorder: A 15-year longitudinal study | 2000
Poulton, R., Caspi, A., Moffitt,
... Show all »
Archives of General Psychiatry, 2000, 57(57), 1053-1058.
Our ref: RO363
Background: Childhood risk factors for the development of adult schizophrenia have proved to have only modest and non-specific effects, and most appear unrelated to the adult phenotype. This paper reports the first direct examination of the longitudinal relation between psychotic symptoms in childhood and adulthood. Methods: Prospective data from a birth cohort (n=761) in which children were asked about delusional beliefs and hallucinatory experiences at age 11, and then followed up to age 26, were analysed. Structured diagnostic interviews were employed at both ages and self-report of schizophreniform symptoms was augmented by other data sources at age 26. Results: Self-reported psychotic symptoms at age 11 predicted a very high risk of a schizophreniform diagnosis at age 26 (OR = 16.4, 95%CI: 3.9-67.8). In terms of attributable risk, 42% of the age-26 schizophreniform cases in the cohort had reported one or more psychotic symptoms at age 11. Age-11 psychotic symptoms did not predict mania or depression at age 26, suggesting specificity of prediction to schizophreniform disorder. The link between child and adult psychotic symptoms was not simply the result of general childhood psychopathology. Conclusions: These findings provide the first evidence for continuity of psychotic symptoms from childhood to adulthood.
« Hide abstract
Occupational injury in a cohort of young New Zealand adults | 2000
Alsop, J., Gafford, J.E., Langley,
... Show all »
Journal of Occupational Health and Safety, 2000, 16(16), 107-116.
Our ref: RO362
The aims of this study were to determine the incidence of occupational injury by industry and occupation, describe the nature and circumstances of serious occupational injury, and describe work-related safety practices in a cohort of young New Zealand adults. The participants of this study were members of the Dunedin Multidisciplinary Health and Development Study. Injury rates varied by gender, full/part-time work status, experience, occupation and industry. Approximately 30% of the young adults who stated that they needed protective equipment had none available to them. The results suggest that the performance of employers in the provision of a safe work environment for young employees needs to be reviewed.
« Hide abstract
The prevalence and intra-oral distribution of periodontal loss of attachment in a birth cohort of 26-year-olds | 2000
Thomson, W.M., Hashim, R., Pack,
... Show all »
Journal of Periodontology, 2000, 71(71), 1840-1845.
Our ref: RO360
Background: Most research efforts in periodontal epidemiology have focused on middle-aged or older people, giving a picture of disease occurrence at a relatively late stage in the natural history of the condition. There is a paucity of comprehensive descriptive data from younger age groups. Understanding the epidemiology and clinical presentation of the condition earlier in the disease course may enable more appropriate interventions. Methods: The aim of this study was to describe the occurrence of gingival recession, probing depth, periodontal loss of attachment, and gingivitis among participants at age 26 in the Dunedin Multidisciplinary Health and Development Study. Gingival recession and probing depth were measured at three sites per tooth in two randomly selected contralateral quadrants. Results: At age 26, 980 (96.2%) of the surviving cohort participated, and periodontal data were available for 914 individuals. Nearly three-quarters of the sample had one or more teeth with 1+mm of gingival recession, and it was observed at over one-fifth of midbuccal sites. Over 15 per cent had one or more sites with probing depths of 4+mm, and nearly one-fifth had one or more sites with 4+mm of LOA. The extent of gingival recession was greatest for midbuccal sites on mandibular premolars, followed by midbuccal sites on maxillary premolars and mandibular molars. In the mandible, more distolingual sites had probing depths of 4+mm, but a higher percentage of mesiobuccal sites was affected in the maxilla, and molars were the most affected, followed by premolars, incisors and canines. Bleeding after probing was more extensive in the mandible than in the maxilla. Conclusions: Periodontal disease appears to be well-established among a small proportion of young adults. The prevalence of gingival recession was higher than expected, with clear differences by site. Pocketing and LOA were more prevalent in mesiobuccal and distolingual sites than the buccal sites, with differences between the jaws.
« Hide abstract
Mental disorders and violence in a total birth cohort: Results from the Dunedin Study | 2000
Arseneault, L., Caspi, A., Moffitt,
... Show all »
Archives of General Psychiatry, 2000, 57(57), 979-986.
Link to full publication »
Our ref: RO358
Background: We report on mental disorders and violence for a birth cohort of young adults, regardless of their contact with the health or justice systems. Methods: We studied 961 young adults who constituted 94% of a total-city birth cohort in New Zealand, April 1, 1972, through March 31, 1973. Past-year prevalence of mental disorders was measured using standardized DSM III R interviews. Past-year violence was measured using self-reports of criminal offending and a search of official conviction records. We also tested whether substance use before the violent offence, adolescent excessive perceptions of threat, and a juvenile history of conduct disorder accounted for the link between mental disorders and violence. Results: Individuals meeting diagnostic criteria for alcohol dependence, marijuana dependence, and schizophrenia spectrum disorder were 1.9 (95% confidence interval [CI], 1.0-3.5), 3.8 (95% CI, 2.2-6.8), and 2.5 (95% CI, 1.1-5.7) times, respectively, more likely than control subjects to be violent. Persons with at least 1 of these 3 disorders constituted one fifth of the sample, but they accounted for half of the sample's violent crimes (10% of violence risk was uniquely attributable to schizophrenia-spectrum disorder). Among alcohol-dependent individuals, violence was best explained by substance use before the offence; among marijuana-dependent individuals, by a juvenile history of conduct disorder; and among individuals with schizophrenia-spectrum disorder, by excessive perceptions of threat and a history of conduct disorder. Conclusions: In the age group committing most violent incidents, individuals with mental disorders account for a considerable amount of violence in the community. Different mental disorders are linked to violence via different core explanations, suggesting multiple-targeted prevention strategies.
« Hide abstract
Socio-economic and behavioural risk factors for tooth-loss from age 18 to 26 among participants in the Dunedin Multidisciplinary Health and Development Study | 2000
Thomson, W.M., Poulton, R., Kruger,
... Show all »
Caries Research, 2000, 34(34), 361-366.
Our ref: RO357
Objective: To determine the risk factors associated with tooth loss between the ages of 18 and 26. Methods: Dental examinations at ages 18 and 26 were conducted on Study members in the Dunedin Multidisciplinary Health and Development Study, and sociodemographic and dental service-use data were collected using a self-report questionnaire. At age 15, an estimate of socio-economic status (SES) for each Study member had been obtained by classifying the occupation of the male parent. A case of tooth loss was defined as an individual who had lost one or more teeth (excluding third molars) due to caries between ages 18 and 26. Logistic regression and Poisson analysis were used to model the occurrence of tooth loss. Results: Among the 821 Study members who were examined at both ages, one or more teeth were lost because of caries by 85 (10.3 per cent). After controlling for sex, SES and visiting pattern, baseline caries experience predicted subsequent tooth loss, with the odds increasing by 2.8 for every increase by 1 in the number of decayed surfaces present at age 18. Episodic dental visitors had 3.1 times the odds of their routine visiting counterparts of losing a tooth over the observation period. The number of teeth lost was, on average, 2.3 times higher among episodic dental visitors. Conclusions: Socio-economic inequalities in tooth loss appear to begin early in the life course, and are modified by individuals’ socio-economic status and dental visiting patterns.
« Hide abstract
Adolescent influences not to smoke, and recall of anti-smoking campaigns | 2000
Healy, G.N., Stanton, W.R., Silva,
... Show all »
Health Promotion Journal of Australia, 2000, 10(10), 148-153.
Our ref: RO356
Few studies have looked at the impact of health promotion campaigns on adolescents or the extent to which adolescents promote anti-smoking messages or are subjected to them by others. Determination of the sources of influence, and the perceived extent of their influence on others, can assist in targeting primary influential groups. A study concerning recognition of anti-smoking campaigns and the attitudes and influences of 18-year-olds (n=937) towards non-smoking was conducted. The main sources of influence came from parents, partners, and self-experience, with general health messages being the major focus. Penetration (reach) of general anti-smoking messages among adolescents was relatively high, although no specific campaign was frequently cited. As anticipated, smokers' attitudes to current smoking issues differed from those of the remainder of the sample. These issues deserve attention in health promotion campaigns, and indicate that the whole social network should be targeted rather than the individual.
« Hide abstract
Two personalities, one relationship: Both partners' personality traits shape the quality of a relationship | 2000
Robins, R.W., Caspi, A., Moffitt,
... Show all »
Journal of Personality and Social Psychology, 2000, 79(79), 251-259.
Our ref: RO355
This research examined how the stable personality traits that each partner brings to an intimate relationship shape the quality of their relationship. Both members of 360 couples (N = 720) completed the Multidimensional Personality Questionnaire and were interviewed about their relationship. We tested six models of the independent and interactive effects of personality on each partner’s reports of relationship satisfaction and quality. Findings show that a woman’s relationship happiness is predicted by her partner’s low Negative Emotionality, high Positive Emotionality, and high Constraint, whereas a man’s relationship happiness is predicted only by his partner’s low Negative Emotionality. Findings also show evidence of additive but not interactive effects: Each partner’s personality contributed independently to relationship outcomes but not in a synergistic way. We discuss these results in relation to models that seek to integrate research on individual differences in personality traits with research on interpersonal processes in intimate relationships.
« Hide abstract
Psychiatric disorders and risky sexual behaviour in young adulthood: cross sectional study in birth cohort | 2000
Ramrakha, S., Caspi, A., Dickson,
... Show all »
BMJ, 2000, 321(321), 263-266.
Link to full publication »
Our ref: RO354
Objective: To determine if risky sexual intercourse, sexually transmitted diseases, and sexual intercourse at an early age are associated with psychiatric disorder. Design: Cross sectional study of a birth cohort at age 21 years with assessments presented by computer (for sexual behaviour) and by trained interviewers (for psychiatric disorder). Setting: New Zealand in 1993-4. Participants: 992 study members (487 women) from the Dunedin multidisciplinary health and development study. Complete data were available on both measures for 930 study members. Main outcome measures: Psychiatric disorders (anxiety, depression, eating disorder, substance dependence, antisocial disorder, mania, schizophrenia spectrum) and measures of sexual behaviour. Results: Young people diagnosed with substance dependence, schizophrenia spectrum, and antisocial disorders were more likely to engage in risky sexual intercourse, contract sexually transmitted diseases, and have sexual intercourse at an early age (before 16 years). Unexpectedly, so were young people with depressive disorders. Young people with mania were more likely to report risky sexual intercourse and have sexually transmitted diseases. The likelihood of risky behaviour was increased by psychiatric comorbidity. Conclusions: There is a clear association between risky sexual behaviour and common psychiatric disorders. Although the temporal relation is uncertain, the results indicate the need to coordinate sexual medicine with mental health services in the treatment of young people.
« Hide abstract
Partner abuse and general crime: How are they the same? How are they different? | 2000
Moffitt, T.E., Krueger, R.F., Caspi,
... Show all »
Criminology, 2000, 38(38), 201-235.
Link to full publication »
Our ref: RO353
Both partner abuse and general crime violate the rights and safety of victims. But are these phenomena the same or are they distinct, demanding their own research and intervention specialities? Are persons who abuse their partners the same people who commit other criminal behavior? Do partner abuse and general crime share the same correlates? We investigated these questions in a birth cohort of over 800 young adults, by testing whether a personality model known to predict general crime would also predict partner abuse. Personality data were gathered at age 18, and self-reported partner abuse and general criminal offending were measured at age 21. Results from modelling latent constructs showed that partner abuse and general crime represent different constructs that are moderately related; they are not merely two expressions of the same underlying antisocial propensity. Group comparisons showed many, but not all, partner abusers also engaged in violence against nonintimates. Personality analyses showed that partner abuse and general crime shared a strong propensity from a trait called Negative Emotionality. However, crime was related to weak Constraint (low self-control), but partner abuse was not. All findings applied to women as well as to men, suggesting that women's partner abuse may be motivated by the same intra-personal features that motivate men's abuse. The results are consistent with theoretical and applied arguments about the uniqueness of partner violence relative to other crime and violence.
« Hide abstract
Dishabituation processes in height fear and dental fear: An indirect test of the non-associative model of fear acquisition | 2000
Poulton, R., Waldie, K.E., Craske,
... Show all »
Behaviour Research and Therapy, 2000, 38(38), 909-919.
Our ref: RO352
The fear dishabituation hypothesis described in the non-associative model of fear acquisition was tested in a longitudinal birth cohort study. Results were consistent with height fear and phobia dishabituation. That is, 're-emergence' of a fear of heights occurred between age 11 and 18 years among individuals who reported higher levels of non-specific stress at age 15. Interestingly, there was no evidence for dental fear dishabituation - a finding consistent with the non-associative model of fear acquisition. Strengths and weaknesses of the study were considered and the results discussed in relation to laboratory-based findings on (dis)habituation.
« Hide abstract
Sexual abstinence at age 21 in New Zealand: the importance of religion | 2000
Paul, C., Fitzjohn, J., Eberhart-Phillips,
... Show all »
Social Science and Medicine, 2000, 51(51), 41548.
Our ref: RO351
Most research on adolescent sexual behaviour has focused on early initiation and consequent risks. We have instead examined the circumstances of young people who have not had sexual intercourse before age 21, in order to throw light on the ways in which young people might resist societal pressures for early sexual intercourse. The sample was a cohort born in Dunedin, New Zealand in 1972/73, formed at age 3, and followed with regular assessments of personal, family and educational functioning to age 21. At age 18 and 21 information on sexual behaviour was collected, using a computer presented questionnaire. The response rate at age 21 was 935/1020 (91.7%) of the survivors of the original cohort. Overall 11.3% of the men and 8.1% of the women reported never having sexual intercourse. Sex with a man was reported by 20 men (4.5%), of whom only two reported having sex only with men. Being first born and being persistently involved in religious activities, measured at both 11 years and 21 years, were significant predictors of abstinence for both sexes. Examination of perceptions of an ideal lifestyle, sexual behaviour and religious involvement showed that religion was an important factor in decisions to delay sexual intercourse past age 20, especially for men. It would be helpful to examine further the features of moral decision making which are characteristic of religious experiences.
« Hide abstract
Chlamydia pneumoniae serological status is not associated with asthma in children or young adults | 2000
Mills, G.D., Lindeman, J.A., Fawcett,
... Show all »
International Journal of Epidemiology, 2000, 29(29), 280-284.
Our ref: RO350
BACKGROUND: The factors that cause the allergic sensitization and inflammation in asthma still remain to be clarified. A role for Chlamydia pneumoniae has been suggested although serological studies have produced conflicting findings. This study aims to clarify the relationship between asthmatic variables and C. pneumoniae serological status. METHODS: A case-control study was undertaken on an asthma-enriched subset from a longitudinal birth cohort. In all, 198 subjects (96 with self-reported asthma) had C. pneumoniae serology (microimmunofluorescence [MIF] IgG, IgA) undertaken at age 11 and age 21 and assessment made in relation to a number of asthma variables. RESULTS: The only statistically significant finding was in subjects self-reporting asthma at age 21 who had evidence of lower IgG titres (P = 0.046), a finding in the opposite direction to that expected from the hypothesis. Subjects with high IgG titres (> or =128) were less likely to have reported ever having asthma; odds ratio (OR) = 0.29, (95% CI: 0.10-0.87). No association existed between symptoms suggestive of asthma in the previous 12 months and either IgG (P = 0.127) or IgA (P = 0.189) antibody titres at age 21. Likewise, no association was found between symptoms suggestive of asthma in the previous two years and C. pneumoniae IgG antibody titre (P = 0.81) at age 11. There was no evidence of an association with any of the other variables examined at either age 11 or age 21. These included use of inhaled steroids, serum IgE levels, airway responsiveness, skin test evidence of atopy, or smoking status. CONCLUSION: The results of this study suggest that C. pneumoniae infection when diagnosed by MIF serology is not a major risk factor for the development of asthma in children and young adults. The study has not, however, addressed the role this organism may play in specific asthmatic subsets or asthma exacerbations.
« Hide abstract
A longitudinal study of cannabis use and mental health from adolescence to early adulthood | 2000
McGee, R., Williams, S.M., Poulton,
... Show all »
Addiction, 2000, 95(95), 491-503.
Our ref: RO349
AIMS: To examine the longitudinal association between cannabis use and mental health. DESIGN: Information concerning cannabis use and mental health from 15 to 21 years was available for a large sample of individuals as part of a longitudinal study from childhood to adulthood. PARTICIPANTS: Participants were enrolled in the Dunedin Multidisciplinary Health and Development Study, a research programme on the health, development and behaviour of a large group of New Zealanders born between 1 April 1972 and 31 March 1973. MEASUREMENTS: Cannabis use and identification of mental disorder was based upon self- report as part of a general assessment of mental health using a standard diagnostic interview. Daily smoking and alcohol use at age 15 were assessed by self-report. Indices of family socio-economic status, family climate and parent-child interaction were formed using information gathered from parent report and behavioural observations over early childhood. Childhood behaviour problems were assessed by parent and teacher report. Attachment to parents was assessed in adolescence. FINDINGS: Cross-sectional associations between cannabis use and mental disorder were significant at all three ages. Both outcome variables shared similar pathways of low socio-economic status and history of behaviour problems in childhood, and low parental attachment in adolescence. Mental disorder at age 15 led to a small but significantly elevated risk of cannabis use at age 18; by contrast, cannabis use at age 18 elevated the risk of mental disorder at age 21. The latter association reflected the extent to which cannabis dependence and other externalizing disorders at age 21 were predicted by earlier level of involvement with cannabis. CONCLUSIONS: The findings suggest that the primary causal direction leads from mental disorder to cannabis use among adolescents and the reverse in early adulthood. Both alcohol use and cigarette smoking had independent associations with later mental health disorder.
« Hide abstract
The child is the father of the man: Personality continuities from childhood to adulthood | 2000
Caspi, A.
Journal of Personality and Social Psychology, 2000, 78(78), 158-172.
Our ref: RO348
This article presents findings about continuities in personality development that have been uncovered in the Dunedin Study. At age 3, children were classified into temperament groups on the basis of observations of their behaviour. In young adulthood, data were collected from Study members themselves, from people who knew them well, and from official records. Undercontrolled 3-year-olds grew up to be impulsive, unreliable and antisocial, and had more conflict with members of their social networks and in their work. Inhibited 3-year-olds were more likely to be unassertive and depressed and had few sources of social support. Early appearing temperamental differences have a pervasive influence on life-course development and offer clues about personality structure, interpersonal relations, psychopathology, and crime in adulthood.
« Hide abstract
The inter-relationship of indices of body composition and zinc status in 11 year old New Zealand children | 2000
Gibson, R.S., Skeaff, M., Williams,
... Show all »
Biological Trace Element Research, 2000, 73(73), 65-77.
Our ref: RO338
Serum zinc and hair zinc concentrations of some New Zealand children aged 11 years, were examined in relation to selected anthropometric indices. Serum zinc concentrations (n=453) in boys and girls were similar, and unrelated to anthropometric indices and hair zinc concentrations. Mean hair zinc concentration (n=620) of the girls was higher than that for the boys (2.95 ± 0.49 vs. 2.46 ± 0.47 mmol/g; p<0.001). Correlation analysis demonstrated that, for the boys, all the studied anthropometric indices with the exception of height, were significantly related to hair zinc composition and that the confounding effects of mid-parent height and the timing of the adolescent growth spurt are small. Results for the girls were similar but less significant. Dichotomizing the hair zinc results divided both the boys and girls into two groups: those with hair zinc < 2.44 mmol/g were heavier (girls 39.0 v 35.2 kg, boys 36.6 v 34.7 kg) and fatter (mid-upper-arm fat area: girls 15.2 v 12.0 cm2, boys 11.1 v 9.5 cm2) compared to their counterparts with hair zinc >2.44mmol/g. The results demonstrate that in these healthy New Zealand children, those with lower hair zinc concentrations are fatter and heavier than their high hair zinc counterparts.
« Hide abstract
Road traffic practices among a cohort of young adults in New Zealand | 1999
Begg, D.J., Langley, J.D.
New Zealand Medical Journal, 1999, 112(112), 9-12.
Our ref: NZ76
Aim: To describe the road safety practices of young adults in New Zealand. Method: Face to face structured interviews, seeking information on a range of road safety practices, were conducted with 948 members of the DMHDS cohort when they were 21 years old. Results: In the 30 days before the interview, 49% of the males and 32% of the females reported driving within two hours of drinking alcohol; 19% males and 8% females reported driving after drinking too much to perhaps be able to drive safely; and 25% males and 9% females reported driving after using marijuana. Also, 25% males and 6% females reported that they often drove fast just for the thrill of it, and 38% males and 11% females reported often driving faster than 120 kph on the open road. Seatbelt use as a driver was reported as always or nearly always by 87% of the males and 95% of the females, but as a rear seat passenger it was 34% for males and 47% for females. Conclusions: Unsafe road traffic practices, especially among males, were unacceptably high. Continued efforts are required to find new ways of addressing these issues.
« Hide abstract
Low self-control, social bonds, and crime: social causation, social selection, or both? | 1999
Wright, B.R., Caspi, A., Moffitt,
... Show all »
Criminology, 1999, 37(37), 479-514.
Link to full publication »
Our ref: RO347
This article examines the social-selection and social-causation processes that generate criminal behavior. We describe these processes with three theoretical models: a social-causation model that links crime to contemporaneous social relationships; a social-selection model that links crime to personal characteristics formed in childhood; and a mixed selection-causation model that links crime to social relationships and childhood characteristics. We tested these models with a longitudinal study in Dunedin, New Zealand, of individuals followed from birth through age 21. We analyzed measures of childhood and adolescent low self-control as well as adolescent and adult social bonds and criminal behavior. In support of social selection, we found that low self-control in childhood predicted disrupted social bonds and criminal offending later in life. In support of social causation, we found that social bonds and adolescent delinquency predicted later adult crime and, further, that the effect of self-control on crime was largely mediated by social bonds. In support of both selection and causation, we found that the social-causation effects remained significant even when controlling for preexisting levels of self-control, but that their effects diminished. Taken together, these findings support theoretical models that incorporate social-selection and social-causation processes.
« Hide abstract
Validity of self-reported crashes and injuries in a longitudinal study of young adults | 1999
Begg, D.J., Langley, J.D., Williams,
... Show all »
Injury Prevention, 1999, 5(5), 142-144.
Our ref: RO346
OBJECTIVES: The aim of this study was to determine the validity of self report as a source of information on crashes and injuries. SETTING: This study was part of the Dunedin Multidisciplinary Health and Development Study (DMHDS), which is a longitudinal study of the health, development, and behaviour of a cohort of young New Zealanders. METHOD: At the age 21 assessment DMHDS study members were asked to report serious injury and motor vehicle traffic crashes experienced over the previous three years. The self reported injuries were compared with the New Zealand Health Information Service (NZHIS) public hospital discharge file to determine the completeness of the self reported data. The traffic crashes were compared with the police traffic crash reports to determine the accuracy of self reported crash details. RESULTS: Twenty five (86%) of the 29 unintentional injuries, six (67%) of the nine assaults, and one (14%) of the six self inflicted injuries on the NZHIS file were self reported. The level of agreement between the self reported crash details and those recorded on the traffic crash report was high. CONCLUSIONS: The results show that self reports can be a useful and valid source of injury and crash data.
« Hide abstract
Relationship between fetal growth and the development of asthma and atopy in childhood | 1999
Leadbitter, P., Pearce, N., Cheng,
... Show all »
Thorax, 1999, 54(54), 905-910.
Our ref: RO345
BACKGROUND: A study was undertaken to investigate the relationship between birth anthropometric measures and the subsequent development of asthma, airway hyperresponsiveness, and atopy in later childhood. METHODS: A longitudinal study was performed on 734 subjects (71%) from a cohort of children born in Dunedin, New Zealand in 1972-73. The birth anthropometric measures were available from hospital records and the main outcome measures of reported asthma, skin prick tests, and methacholine hyperresponsiveness were measured at the age of 13 years, while the serum total IgE was measured at 11 years. RESULTS: After adjustment for other factors, infants with a larger head circumference at birth tended to have higher serum total IgE at 11 years of age (p = 0.02) but IgE was not associated significantly with birth length or birth weight. The adjusted odds ratio for raised serum IgE (>150 IU/ml) in infants with a head circumference of 37 cm or more was 3.4 (95% CI 1.4 to 7.9). In contrast, recent asthma symptoms were positively associated with birth length (p = 0. 04) but not with head circumference. The adjusted odds ratio for asthma in the previous two years in infants with a birth length of 56 cm or more was 6.4 (95% CI 2.0 to 19.8). Infants with a birth weight of less than 3.0 kg had an odds ratio for reported asthma of 0.2 (95% CI 0.0-0.6). There were no significant associations of any of the birth parameters with skin prick positivity, reported hay fever, or eczema. CONCLUSIONS: These results suggest that increased fetal growth is related to an increased risk of asthma and atopy in childhood. The precision of the findings is limited by the small numbers in the extreme categories of each birth parameter, but the results are consistent with intrauterine programming of the developing respiratory and immune systems.
« Hide abstract
Predicting BMI in young adults from childhood data using two approaches to modelling adiposity rebound | 1999
Williams, S.M., Davie, G., Lam,
... Show all »
International Journal of Obesity, 1999, 23(23), 348-354.
Our ref: RO344
OBJECTIVE: To identify the age of adiposity rebound and the value of its associated BMI and examine their association with BMI at ages 18 and 21 y for males and females. DESIGN: A longitudinal study of a large cohort of people born in Dunedin, New Zealand between 1972-1973. SUBJECTS: Four hundred and seventy-four males and 448 females aged between birth and 21 y. MEASUREMENTS: BMI was derived from measurements of weight and height made when the participants were born and at intervals from age 3-21 y. RESULTS: When a random coefficients model was fitted to the data for those who had five or more measures of BMI between age 3 and age 18y, adiposity rebound occurred at 6.0 y of age for boys and 5.6y for girls. The values of BMI associated with these were 15.7 kg/m2 for boys and 15.5 kg/m2 for girls. The correlations between age at adiposity rebound and BMI at ages 18 and 21 y were between -0.72 and -0.65 for boys and -0.59 and -0.47 for girls. These were higher than those derived from fitting individual curves or from deriving the adiposity rebound from data collected up to age 11 y. The correlation between BMI at age 7 y and BMI at ages 18 and 21 y were 0.70 and 0.61 for boys and 0.56 and 0.52 for girls. The correlations between measures of skeletal maturity at age 7 y and adiposity rebound were statistically significant for boys but not for girls. CONCLUSIONS: BMI in early adulthood was associated with both age of adiposity rebound and BMI at that age. As the correlations between BMI at age 7 y and BMI at ages 18 and 21 y were similar in magnitude, BMI at age 7 y may be a more practical way of predicting BMI in early adulthood.
« Hide abstract
Twins and maternal smoking, ordeals for the fetal origins hypothesis. A cohort study | 1999
Williams, S.M., Poulton, R.
BMJ, 1999, 3(3), 897-900.
Our ref: RO341
OBJECTIVE: To assess the direct and indirect effects of being a twin, maternal smoking, birth weight, and mother's height on blood pressure at ages 9 and 18 years. DESIGN: Longitudinal study. Subjects: Cohort born in 1972-3. Setting: Dunedin, New Zealand. Main outcome measure: Blood pressure at ages 9 and 18 years. RESULTS: Compared with singletons, twins had a systolic blood pressure 4.55 (95% confidence interval 1.57 to 7.52) mm Hg lower at age 9 after adjustment for direct and indirect effects of sex, maternal smoking, mother's height, socioeconomic status, and birth weight, as well as concurrent height and body mass index. Blood pressure in children whose mothers had smoked during pregnancy was 1.54 (0.46 to 2.62) mm Hg higher than in those whose mothers did not. The total effect of birth weight on systolic blood pressure at age 9 was -0.78 (-1.76 to 0.20) mm Hg and that for mother's height was 0.10 (0.06 to 0.14) mm Hg. Similar results were obtained for systolic blood pressure at age 18. The total effect of twins, maternal smoking, and birth weight on diastolic blood pressure was not significant at either age. CONCLUSIONS: Twins had lower birth weight and lower systolic blood pressure at ages 9 and 18 than singletons. This finding challenges the fetal origins hypothesis. The effect of maternal smoking was consistent with the fetal origin hypothesis in that the infants of smokers were smaller and had higher blood pressure at both ages. This may be explained by pharmacological rather than nutritional effects. The total effect of birth weight on systolic blood pressure, after its indirect effect working through concurrent measures of height and body mass index was taken into account, was small.
« Hide abstract
Reconsidering the relationship between SES and delinquency: causation but not correlation | 1999
Wright, B.R., Caspi, A., Moffitt,
... Show all »
Criminology, 1999, 37(37), 175-194.
Link to full publication »
Our ref: RO336
Many theories of crime have linked low levels of socioeconomic status (SES) to high levels of delinquency. However, empirical studies have consistently found weak or nonexistent correlations between individuals' SES and their self-reported delinquent behavior. Drawing upon recent theoretical innovations (Hagan et al., 1985; Jensen, 1993; Tittle, 1995), we propose that this apparent contradiction between theory and data may be reconciled by recognizing that SES has both a negative and a positive indirect effect upon delinquency that, in tandem, results in little overall correlation between the two. We tested this proposal with longitudinal data from the Dunedin Multidisciplinary Health and Development Study. We used measures of parental SES recorded at Study members' birth through age 15, social-psychological characteristics at age 18, and self-reported delinquency at ages 18 and 21. We found that low SES promoted delinquency by increasing individuals' alienation, financial strain and aggression, and by decreasing educational and occupational aspirations, whereas high SES promoted individuals' delinquency by increasing risk taking and social power, and by decreasing conventional values. These findings suggest a reconciliation between theory and data, and they underscore the conceptual importance of elucidating the full range of causal linkages between SES and delinquency.
« Hide abstract
Low socioeconomic status and mental disorders: A longitudinal study of selection and causation during young adulthood | 1999
Miech, R.A., Caspi, A., Moffitt,
... Show all »
American Journal of Sociology, 1999, 104(104), 1096-1131.
Link to full publication »
Our ref: RO335
This article examines low socioeconomic status (SES) as both a cause and a consequence of mental illnesses by investigating the mutual influence of mental disorders and educational attainment, a core element of SES. The analyses are based on a longitudinal panel design and focus on four disorders: anxiety, depression, antisocial disorder, and attention deficit disorder. The article shows that each disorder has a unique relationship with SES, highlighting the need for greater consideration of antisocial disorders in the status attainment process and for further theoretical development in the sociology of mental disorders to account for disorder-specific relations with SES.
« Hide abstract
Staying in school protects boys with poor self-regulation in childhood from later crime: A longitudinal study | 1999
Henry, B., Caspi, A., Moffitt,
... Show all »
International Journal of Behavioural Development, 1999, 23(23), 1049-1073.
Link to full publication »
Our ref: RO334
Based on a theoretical model that emphasises the distinction between individual and contextual determinants of antisocial behaviour, the current study examined whether school attendance throughout adolescence acted as a protective factor for individuals at risk for criminal behaviour in early adulthood. Specifically, Lack of Control, an index of self-regulation which has previously been shown to predict later criminal behaviour, was expected to interact with early school leaving to predict self-reports and official records of criminal behaviour collected at age 21. Multivariate regression analyses revealed a significant three-way interaction between school attendance, self-regulation, and sex. Among males, after controlling for the effects of socioeconomic status and IQ, the main effects for Lack of Control and school attendance were found to be significant; additionally, the interaction between Lack of Control and school attendance was significant, indicating that the strength of the relation between Lack of Control and criminal outcomes was moderated by school attendance. The main effects for Lack of Control and school attendance were significant for females, but the interaction between Lack of Control and school attendance was not significant. The protective effect of school attendance among males could not be accounted for by differences in familial disruption or adolescent delinquency.
« Hide abstract
A longitudinal study of lifestyle factors as predictors of injuries and crashes among young adults | 1999
Begg, D.J., Langley, J.D., Williams,
... Show all »
Accident Analysis and Prevention, 1999, 31(31), 1-11.
Our ref: RO328
This study was part of the Dunedin Multidisciplinary Health and Development Study. This is a longitudinal study of the health, development and behaviour of a cohort of 1037 young people born in Dunedin, New Zealand between 1 April 1972 and 31 March 1973. Explanatory measures covering background, behavioural and personality factors were obtained at ages 15 and 18 and were used as potential predictors of outcomes reported at age 21. Four outcomes were considered: any crash, injury crash, non-injury crash, and serious injury (not motor vehicle related). Overall, very few lifestyle factors were important predictors of any of these outcomes. Factors that were shown to predict injury crashes differed from those that predicted non- injury crashes. Also, those that predicted a traffic crash differed from those that predicted a serious non-traffic injury. These results suggest that focusing injury prevention efforts on changing the lifestyles of young adults is unlikely to reduce overall crash risk, and would have little impact on the risk of serious injury.
« Hide abstract
Water trauma and swimming experiences up to age 9 and fear of water at age 18: A longitudinal study | 1999
Poulton, R., Menzies, R.G., Craske,
... Show all »
Behaviour Research and Therapy, 1999, 37(37), 39-48.
Link to full publication »
Our ref: RO322
A small number of retrospective studies on the etiology of specific fears have obtained findings consistent with a biological (non- associative) explanation of fear acquisition. Unfortunately, reliance on imperfect memory to recall conditioning events which occurred many years earlier limits the conclusions that can be drawn from such data. The present investigation attempts to overcome this methodological shortcoming by examining the relationship between water trauma (i.e. conditioning) and water skills (e.g. swimming) before the age of 9 and the presence of water fear and phobia at age 18 in a longitudinal birth cohort. We found no evidence of a relationship between water confidence and water trauma up to the age of 9 and fear of water at age 18. Similar findings were obtained for water phobia at age 18 with the exception that study members who were less able to immerse themselves in water with confidence at age 9 were more likely to report water phobia at age 18. Associative and non-associative explanations of these findings were discussed.
« Hide abstract
Personality traits in late adolescence predict mental disorders in early adulthood: A prospective-epidemiological study | 1999
Krueger, R.F.
Journal of Personality, 1999, 67(67), 39-65.
https://doi.org/10.1111/1467-6494.00047
Our ref: RO318
Prospective relations between personality traits and mental disorders were assessed in a longitudinal study of a representative birth cohort of young men and women from Dunedin, New Zealand. Personality traits were assessed via self-report questionnaire at age 18, and mental disorders were assessed via diagnostic interview at both ages 18 and 21. High negative emotionality (a propensity to experience aversive affective states) at age 18 was linked with affective, anxiety, substance dependence, and antisocial personality disorders at age 21 when corresponding mental disorders at age 18 were controlled. Low constraint (difficulty inhibiting the expression of affect and impulse) at age 18 was linked with substance dependence and antisocial personality disorders at age 21 when corresponding mental disorders at age 18 were controlled. The findings are discussed in terms of their implications for the development and treatment of mental disorders in young adulthood.
« Hide abstract
Iron deficiency and anaemia in a longitudinal study of New Zealanders at ages 11 and 21 years | 1998
Fawcett, J.P., Brooke, M., Beresford,
... Show all »
New Zealand Medical Journal, 1998, 111(111), 400-402.
Our ref: NZ75
AIMS: To determine iron status in a longitudinal study of New Zealanders, the Dunedin Multidisciplinary Health and Development Study (DMHDS), at ages 11 (1983-4) and 21 (1993-4). METHODS: Red cell variables were measured in 553 (298 males, 255 females) and 784 (413 males, 371 females) members of the DMHDS at ages 11 and 21, respectively. A total of 456 (259 males, 197 females) members were tested at both ages. Serum ferritin was measured at age 21 only. RESULTS: The prevalence of anaemia in females (haemoglobin < 120 g/L) increased from 3.1% at age 11 to 5.8% at age 21 (pregnant women excluded). There was a significant association between low haemoglobin at age 11 and low haemoglobin at age 21. In males, prevalence of anaemia decreased from 2.3% at age 11 to 0.97% (haemoglobin < 130 g/L) at age 21. The prevalence of iron deficiency (ferritin < 12 ng/mL) at age 21 was 0.24% in men and 6.7% in women. The prevalence of iron deficiency with anaemia at age 21 was zero in men and 2.2% in women. CONCLUSIONS: The prevalences of anaemia and iron deficiency in the DMHDS appear to be low by comparison with similar populations in other countries. Anaemia appears to be a stable trait in young women and screening may be useful for its early detection.
« Hide abstract
Physical assault in New Zealand: the experience of 21 year old men and women in a community sample | 1998
Martin, J., Nada-Raja, S., Langley,
... Show all »
New Zealand Medical Journal, 1998, 111(111), 158-160.
Our ref: NZ74
AIM: To obtain epidemiological information on physical assault in a high risk group of New Zealanders. METHOD: Rates of physical assault in the preceding twelve months were ascertained by interview in a cohort of 21 year old, Dunedin-born men (n = 482) and women (n = 462). RESULTS: Forty-five percent of the men and one quarter of the women reported at least one physical assault, either completed, attempted or threatened. A small proportion of these received medical treatment. Most serious assaults were by a perpetrator who was thought to have been drinking alcohol. Most assaults on men were by strangers but partners carried out more assaults against women, especially those receiving medical treatment. One quarter of all assaults on women were by other women, compared to 15% of the assaults on men. Differences between patterns of assaults on women and on men are discussed. CONCLUSION: It is important for doctors to be aware of the widespread occurrence of interpersonal violence in New Zealand and its underreporting.
« Hide abstract
Caregiving and well-being in a sample of women in midlife | 1998
Knight, R.G., Williams, S.M., McGee,
... Show all »
Australian and New Zealand Journal of Public Health, 1998, 22(22), 616-620.
Our ref: RO361
A survey of 742 women in midlife found that 12% were involved in the care of another person with a chronic health disorder. Of note was the diversity of circumstances that led to the women becoming caregivers. Further, about a third of the carers were supporting more than one person. Carers did not differ on measures of depression or subjective health ratings from persons not involved in care. Burden scores were predicted by co-residence, low satisfaction with social support, and poorer health ratings on the part of the carers but not by the relationship between the person cared for and the carer.
« Hide abstract
Impact of liking for advertising and brand allegiance on drinking and alcohol-related aggression: A longitudinal study | 1998
Casswell, S., Zhang, J.F.
Addiction, 1998, 93(93), 1209-1217.
Our ref: RO343
Aim: To test a hypothesized model of the effect of televised alcohol advertising and allegiance to specific brands of beer on subsequent beer consumption and self-reports of aggressive behaviour linked with drinking. Findings: The hypothesized model assumed a positive impact of liking of alcohol advertising and brand allegiance at age 18 on the volume of beer consumed at age 21 and self-reports of alcohol-related aggressive behaviour. This was found to be a good fit to the data from the longitudinal study. Conclusion: This measurable impact of alcohol advertising occurred during a time of decline in aggregate alcohol in New Zealand. While this effect was not large enough to halt the decline in aggregate alcohol consumption it does indicate a measurable, specific impact of broadcast alcohol advertising on alcohol consumption and related behaviour which is of relevance for public health policy.
« Hide abstract
Is mental health in childhood a major predictor of smoking in adolescence | 1998
McGee, R., Williams, S.M., Stanton,
... Show all »
Addiction, 1998, 93(93), 1869-1874.
Link to full publication »
Our ref: RO342
Aim: To test an extended version of Pomerleau's (1997) hypothesis that children with mental health problems are at higher risk of smoking in preadolescence and adolescence. Findings: None of the potential risk factors of gender, childhood disadvantage or childhood mental health problems predicted onset of smoking in pre-adolescence. Daily smoking at age 15 was best predicted by smoking in preadolescence, being female and experiencing childhood disadvantage. Pre-adolescent mental health was only weakly predictive of later smoking and this association appeared to be confounded with background disadvantage. Conclusions: Little support was found for the extension of Pomerleau's (1997) hypothesis to childhood mental health. The findings also run counter to recent suggestions for targeting smoking prevention at groups of children with mental health disorders.
« Hide abstract
Dental caries and changes in dental anxiety in late adolescence | 1998
Kruger, E., Thomson, W.M., Poulton,
... Show all »
Community Dentistry and Oral Epidemiology, 1998, 26(26), 355-359.
Our ref: RO340
Little is known about changes in dental anxiety with ageing and their association with changes in oral health. This study examined the relationship between changes in dental caries experience and dental anxiety from 15 to 18 years of age among adolescent participants in the Dunedin Multidisciplinary Health and Development Study. Dental anxiety was estimated using the Corah Dental Anxiety Scale (DAS), and individuals with a DAS score of 13+ were identified as being dentally anxious. Dental examinations were performed on 649 individuals at ages 15 and 18, and a DMFS score was computed for each. Caries prevalence among those who were dentally anxious at both 15 and 18 years was significantly higher than for those who were not at either age. Regression analysis revealed that dental anxiety predicted caries incidence between ages 15 and 18 years. Dental anxiety is likely to be a significant predictor of dental caries experience, and may be a risk factor for dental caries incidence.
« Hide abstract
Where young people with multiple sexual partners seek medical care: implications for screening for chlamydial infection | 1998
Dickson, N., Paul, C., Herbison,
... Show all »
Sexually Transmitted Infections, 1998, 74(74), 445-447.
Our ref: RO339
Objective: To investigate among young people the relation between the number of sexual partners and use of medical services in order to guide planning of sexually transmitted disease screening. Design: Cross sectional study within a birth cohort using a questionnaire presented by computer. Setting: Dunedin, New Zealand in 1993-4. Subjects: 477 men and 458 women aged 21 enrolled in the Dunedin Multidisciplinary Health and Development Study, comprising 91.7% of survivors of the cohort. Results: Men with multiple sexual partners in the previous year were less likely to have a general practitioner than men with one or no partners (76.2% v 88.5%, p<0.01). Among the women the respective proportions (83.1% and 88.4%) were not significantly different. Significantly more women than men (75.8% v 50.7%, p=0.03) with five or more partners in the previous year had visited their own general practitioner over that period. Among the sexually experienced, more women than men attended any setting appropriate for sexually transmitted disease screening (93.6% v 71.6%, p<0.001). Conclusions: In New Zealand a screening programme for sexually transmitted diseases among young adults reliant on invitation by their own general practitioner would be biased towards those at less risk. Opportunistic screening in general practice would potentially include only about half the most sexually active men and three quarters of such women over a 12 month period. The extension of opportunistic screening to other settings considered appropriate for discussion of sexual health issues could potentially engage the vast majority of women, but not men, at most risk. Any screening programme should incorporate an effective method of finding and treating the sexual partners of infected women.
« Hide abstract
A longitudinal investigation of psychological and social predictors of traffic convictions among young New Zealand drivers | 1998
Reeder, A.I., Alsop, J., Begg,
... Show all »
Transportation Research Part F: Traffic Psychology and Behaviour, 1998, 1(1), 25-45.
Link to full publication »
Our ref: RO337
The study aimed to determine, irrespective of driver licence status, whether young drivers with traffic conviction records at age 21 years differed from those without, with respect to prior personal characteristics measured around the minimum age of licensure (presently 15 years in New Zealand). From a broad range of psychological and social factors, the strongest and most stable predictors were male gender, part time work, rural residence, marijuana use, estimated driving exposure during the follow up period, and early motorcycle riding. Experiences of riding as a passenger with young drivers or with an alcohol intoxicated adult driver were also significant predictors. Some road safety implications are considered.
« Hide abstract
Seroprevalence of Helicobacter pylori in a longitudinal study of New Zealanders at ages 11 and 21 | 1998
Fawcett, J.P., Shaw, J.P., Brooke,
... Show all »
Australian and New Zealand Journal of Medicine, 1998, 28(28), 585-589.
Our ref: RO333
Background: Helicobacter pylori seroprevalence increases with age in adult life but spontaneous reversion may occur in childhood and adolescence. Aims: To determine the seroprevalence of H. pylori in a longitudinal study of New Zealanders at ages 11 and 21. Methods: Serum from members of the DMHDS at age 11 (n=561; 303 males, 258 females) and 21 (n=785; 413 males, 372 females) was tested for H. pylori antibodies. A large proportion of those tested at age 11 was retested at age 21 (n=465; 262 males, 203 females). Serological status was examined in terms of gender, socioeconomic status (SES) and self-reported use of antibiotics. Results: The seroprevalence of H. pylori decreased by 38% from 6.6% (37/561) at age 11 to 4.1% (32/785) at age 21. Seroprevalence at age 11 was not associated with gender or SES. For those tested at both ages, the drop in seroprevalence from 6.7% to 4.1% was statistically significant (t-2.57, p<0.01, paired t-test) and was much greater in females (71%) than males (12%). Of the 31 seropositive individuals at age 11, 17 (six males, 11 females) seroreverted and self-reported antibiotic use in the year preceeding age 21 was more common in females (8/11) than males (0/6). Of the 434 seronegative individuals at age 11, only five (four males, one female) had seroconverted at age 21. Conclusions: Seroprevalence in the DMHDS declined from age 11 to 21 predominantly in females. The decline involved a greater rate of seroreversion and lower rate of seroconversion in females than males.
« Hide abstract
Are young adults checking their skin for Melanoma? | 1998
Douglass, H.M., McGee, R., Williams,
... Show all »
Australian and New Zealand Journal of Public Health, 1998, 22(22), 562-567.
Our ref: RO331
This study examined the prevalence and predictors of self screening for melanoma in a large sample of young New Zealanders. A self-report questionnaire was administered to a sample of 909 21-year-olds to investigate if young adults check their skin for changes in lesions which could be melanoma, and to identify the factors which influence this behaviour and any subsequent help seeking. Fifty-three per cent reported checking their skin in the past year, with 20% noticing a change in a mole or freckle. Forty-five per cent of those who noticed a change sought medical advice. The most common reason for not seeking advice was cost. Women were more likely than men to have checked their skin, to have noticed a change and to have sought medical advice. In addition to gender, tendency to self check was also associated with knowledge of melanoma and perceived risk of melanoma. These results are discussed in light of the current debate regarding skin cancer screening. This study fills a gap in the literature regarding self screening for melanoma in young adults and identifies ways in which future prevention campaigns might be modified to address the concerns of this age group.
« Hide abstract
Persistence, remission and relapse of childhood asthma: a longitudinal study from age 9 to age 21. | 1998
Sears, M.R., Wiecek, E., Willan,
... Show all »
European Respiratory Journal, 1998, 12(12), 401s.
Our ref: RO330
Many children with wheezing symptoms in childhood become asymptomatic in adolescence, others have persistent wheezing, while others remit then relapse. We have followed an unselected birth cohort of New Zealand children from age 9 to age 21, with questionnaires, pulmonary function measurements including airway responsiveness, and skin tests, with reviews every 2 or 3 years. Of 815 subjects seen at age 9, 601 (74%) provided data on all subsequent surveys. persistent wheezing (3 or more episodes per year) was defined as wheezing reported at every survey from the age at which it was first documented, remission as permanent loss of previously reported wheezing, relapse as recurrence of wheezing symptoms after negative reports at one or more surveys, and normal as never reporting 3 or more wheezing episodes in a year. At age 21, 21.3% of the 601 subjects had persistent wheezing, 6.8% had had wheezing followed by full remission, 13.4% had had wheezing then remission followed by relapse, 21.8% had wheezing reported at only one survey, 4.8% intermittently reported wheezing with no classifiable pattern, and 31.9% had never reported symptoms. Hence by age 21, 68.1% of the birth cohort had reported recurrent wheezing at one or more surveys, 46.3% had reported wheezing at two or more surveys, and 30% had wheezing persisting into early adult life. The strongest risk factors for persistence to age 21 were atopy to house dust mite and cat, and increased airway responsiveness at age 9, odds ratio >2.0 for each of these factors.
« Hide abstract
Herpes simplex type 2 infection in a cohort aged 21 years. | 1998
Eberhart-Phillips, J., Dickson, N., Paul,
... Show all »
Sexually Transmitted Infections, 1998, 74(74), 216-218.
Our ref: RO327
OBJECTIVES: To measure the prevalence of HSV-2 antibodies in a birth cohort of 21 year old New Zealanders from whom detailed sexual histories had been obtained, and to assess the potential for HSV-2 serology in characterising a young adult population's risk for sexually transmitted diseases (STD). METHODS: Sera from 784 cohort members were tested using an indirect IgG enzyme linked immunoassay specific to the HSV-2 glycoprotein G. Positive results were confirmed by western blot. RESULTS: In all, 27 subjects were seropositive for HSV-2 (3.4%), only seven of whom gave a history of genital herpes (26%). Risk among females increased with lifetime number of partners, while risk for males increased with having a first partner who was aged 16 years or under. CONCLUSIONS: The seroprevalence of HSV-2 infection in this cohort was low, but similar to that seen in several other populations in this age group. HSV-2 seropositivity did not appear to be a sensitive marker for high risk sexual activity in this young population. This may be because a critical mass of HSV-2 carriers has not accumulated among potential partners by age 21 years.
« Hide abstract
