The Dunedin Study - DMHDRU

Publications

All peer reviewed publications are listed below.

Displaying page 3 of 21.

Hancox, R. J. , Subbarao, P.J., Sears, M.R. | 2012
Relevance of birth cohorts to assessment of asthma persistence

Current Allergy and Asthma Reports , 2012, 12(12), 175-184.
http://www.ncbi.nlm.nih.gov/pubmed/22415313
Our ref: RO622

Show abstract » The definition of persistent asthma in longitudinal studies reflects symptoms reported at every assessment with no substantive asymptomatic periods. Early-childhood wheezing may be transient, especially if it is of viral etiology. Longitudinal studies provide greater opportunity to confirm the diagnosis by variability of symptoms, objective measurements, and therapeutic responses. Several clinical phenotypes of childhood asthma have been identified, with general consistency between cohorts. Persistent wheezing is often associated with loss of lung function, which is evident from early-childhood and related to persistent inflammation and airway hyperresponsiveness. Female sex, atopy, airway responsiveness, and personal smoking, but not exposure to environmental tobacco smoke, are risk factors for persistence of childhood asthma into adulthood. The effect of breastfeeding remains controversial, but gene-environment interactions may partly explain outcomes. Understanding the natural history and underlying causes of asthma may lead to development of strategies for primary prevention.
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Belsky, D.W., Moffitt, T.E., Houts, R., Bennett, G.G., Biddle, A.K., Blumenthal, J.A., Evans, J.P., Harrington, H. L., Sugden, K., Williams, B.S., Poulton, R. , Caspi, A. | 2012
Polygenic Risk for Adult Obesity is Mediated by Rapid Childhood Growth: Evidence from a 4-Decade Longitudinal Study

Archives of Pediatrics & Adolescent Medicine, 2012, 166(166), 515-521.
Our ref: RO621

Show abstract » Objective To test how genomic loci identified in genome-wide association studies influence the development of obesity. Design A 38-year prospective longitudinal study of a representative birth cohort. Setting The Dunedin Multidisciplinary Health and Development Study, Dunedin, New Zealand. Participants One thousand thirty-seven male and female study members. Main Exposures We assessed genetic risk with a multilocus genetic risk score. The genetic risk score was composed of single-nucleotide polymorphisms identified in genome-wide association studies of obesity-related phenotypes. We assessed family history from parent body mass index data collected when study members were 11 years of age. Main Outcome Measures Body mass index growth curves, developmental phenotypes of obesity, and adult obesity outcomes were defined from anthropometric assessments at birth and at 12 subsequent in-person interviews through 38 years of age. Results Individuals with higher genetic risk scores were more likely to be chronically obese in adulthood. Genetic risk first manifested as rapid growth during early childhood. Genetic risk was unrelated to birth weight. After birth, children at higher genetic risk gained weight more rapidly and reached adiposity rebound earlier and at a higher body mass index. In turn, these developmental phenotypes predicted adult obesity, mediating about half the genetic effect on adult obesity risk. Genetic associations with growth and obesity risk were independent of family history, indicating that the genetic risk score could provide novel information to clinicians. Conclusions Genetic variation linked with obesity risk operates, in part, through accelerating growth in the early childhood years after birth. Etiological research and prevention strategies should target early childhood to address the obesity epidemic.
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Slutske, W., Moffitt, T.E., Caspi, A., Poulton, R. | 2012
Undercontrolled temperament at age 3 predicts disordered gambling at age 32: a longitudinal study of a complete birth cohort

Psychological Science, 2012, 23(23), 510-516.
Our ref: RO620

Show abstract » Using data from the large, 30-year prospective Dunedin cohort study, we examined whether preexisting individual differences in childhood temperament predicted adulthood disordered gambling (a diagnosis covering the full continuum of gambling-related problems). A 90-min observational assessment at age 3 was used to categorize children into five temperament groups, including one primarily characterized by behavioral and emotional undercontrol. The children with undercontrolled temperament at 3 years of age were more than twice as likely to evidence disordered gambling at ages 21 and 32 than were children who were well-adjusted at age 3. These associations could not be explained by differences in childhood IQ or family socioeconomic status. Cleanly demonstrating the temporal relation between behavioral undercontrol and adult disordered gambling is an important step toward building more developmentally sensitive theories of disordered gambling and may put researchers in a better position to begin considering potential routes to disordered-gambling prevention through enhancing self-control and emotional regulation.
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Crocombe, L. A. , Broadbent, J. M. , Thomson, W. M. , Brennan, D. S. , Poulton, R. | 2012
Impact of dental visiting trajectory patterns on clinical oral health and oral-health-related quality of life

Journal of Public Health Dentistry, 2012, 72(72), 36-44.
http://onlinelibrary.wiley.com/doi/10.1111/j.1752-7325.2011.00281.x/full
Our ref: RO619

Show abstract » Background: Previous studies have shown variation in long-term dental visiting but little is known about the oral health outcomes of such variation. Objective: The objective of this study is to determine the association of different dental visiting trajectories with dental clinical and oral health-related quality of life (OHRQoL) indicators. Methods: This study utilized data from the Dunedin Multidisciplinary Health and Development Study, a continuing longitudinal study of 1,037 babies born in Dunedin (New Zealand) between April 1, 1972 and March 31, 1973. Data presented here were collected at ages 15, 18, 26, and 32 years. Three categories of dental attendance were identified in earlier research, namely: regulars (n = 285, 30.9 percent of the cohort), decliners (441, 55.9 percent), and opportunistic users (107, 13.1 percent). Results: There was a statistically significant association between opportunistic dental visiting behavior and decayed missing and filled surfaces score (Beta = 3.9) as well as missing teeth because of caries (Beta = 0.7). Nonregular dental visiting trajectories were associated with higher Oral Health Impact Profile (OHIP-14) scores (Beta = 2.1) and lower self-rated oral health scores (prevalence ratio = 0.8). Conclusion: Long-term, postchildhood dental attendance patterns are associated with oral health in adulthood, whether defined by clinical dental indicators or OHRQoL. Improving dental visiting behavior among low socioeconomic status groups would have the greatest effect on improving oral health and reducing oral health impacts.
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Shearer, D.M., Thomson, W. M. , Caspi, A., Moffitt, T.E., Broadbent, J. M. , Poulton, R. | 2012
Family history and oral health: findings from the Dunedin Study

Community Dentistry and Oral Epidemiology , 2012, 40(40), 105-115.
http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0528.2011.00641.x/full
Our ref: RO618

Show abstract » Context: The effects of the oral health status of one generation on that of the next within families are unclear. Objective: To determine whether parental oral health history is a risk factor for oral disease. Methods: Oral examination and interview data were collected during the age-32 assessments in the Dunedin Study. Parental data were also collected on this occasion. The sample was divided into two familial-risk groups for caries / tooth loss (high risk and low risk) based on parents self-reported history of tooth loss at the age-32 assessment interview. Main outcome measures: Probands dental caries and tooth loss status at age 32, together with lifelong dental caries trajectory (age 532). Results: Caries / tooth loss risk analysis was conducted for 640 proband-parent groups. Reference groups were the low-familial-risk groups. After controlling for confounding factors (sex, episodic use of dental services, socio-economic status and plaque trajectory), the prevalence ratio (PR) for having lost 1+ teeth by age 32 for the high-familial-risk group was 1.41 [95% confidence interval (CI) 1.05, 1.88] and the rate ratio for DMFS at age 32 was 1.41 (95% CI 1.24, 1.60). In the high-familial-risk group, the PR of following a high caries trajectory was 2.05 (95% CI 1.37, 3.06). Associations were strongest when information was available about both parents oral health. Nonetheless, when information was available for one parent only, associations were significant for some outcomes. Conclusions: People with poor oral health tend to have parents with poor oral health. Family / parental history of oral health is a valid representation of the intricacies of the shared genetic and environmental factors that contribute to an individuals oral health status. Associations are strongest when data from both parents can be obtained.
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Piquero, N.L., Moffitt, T.E. | 2012
Can Childhood Factors Predict Workplace Deviance?

Justice Quarterly, 2012, 1-29.
http://dx.doi.org/10.1080/07418825.2012.661446
Our ref: RO617

Show abstract » Compared to the more common focus on street crime, empirical research on workplace deviance has been hampered by highly select samples, cross-sectional research designs, and limited inclusion of relevant predictor variables that bear on important theoretical debates. A key debate concerns the extent to which childhood conduct-problem trajectories influence crime over the life-course, including adults workplace crime, whether childhood low self-control is a more important determinant than trajectories, and/or whether each or both of these childhood factors relate to later criminal activity. This paper provides evidence on this debate by examining two types of workplace deviance: production and property deviance separately for males and females. We use data from the Dunedin Multidisciplinary Health and Development Study, a birth cohort followed into adulthood, to examine how childhood factors (conduct-problem trajectories and low self-control) and then adult job characteristics predict workplace deviance at age 32. Analyses revealed that none of the childhood factors matter for predicting female deviance in the workplace but that conduct-problem trajectories did account for male workplace deviance.
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van Roode, T., Dickson, N., Sharples, K., Paul, C. | 2012
Patterns of sexual partnering and reproductive history: Associations with timing of first birth in a birth cohort

Perspective on Sexual and Reproductive Health, 2012, 44(44), 48-56.
doi: 10.1363/4404812
Our ref: RO615

Show abstract » CONTEXT:The associations between timing of first live birth and previous sexual behavior and pregnancies are not well understood. METHODS: Members of a 1972'1973 New Zealand birth cohort were surveyed at ages 21, 26 and 32 about their sexual and reproductive histories; 506 men and 479 women participated in at least one assessment. Relative risks and 95% confidence intervals were calculated using Poisson regression to examine associations between the likelihood of first live birth at specific ages (prior to age 21, at age 21'25, at age 26'31) and selected characteristics. RESULTS: Birth prior to age 21 was more likely for men and women who initiated intercourse before age 15 (relative risks, 3.1 and 2.0, respectively), and less likely for those who initiated at age 18 or later (0.3 and 0.1, respectively), than for those aged 15'17 at first coitus. Prior miscarriage was associated (although sometimes marginally) with an elevated likelihood of first birth across genders and ages (1.7'1.8). Prior abortion was associated with an elevated likelihood of first birth at age 21'25 for women (1.6) and a reduced likelihood at age 26'31 for men (0.5). Having multiple sexual partners at age 21'25 was negatively associated with the likelihood of a first birth at age 26'31 for men. Marriage and cohabitation were positively associated with birth timing. CONCLUSIONS: Early sexual initiation and relationship instability may promote parenthood at younger ages, whereas greater relationship stability may do so at older ages.
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Sligo, J., Buxton, J., McComb, S., Rothstein, D., Salter, G., Hancox, R. J. | 2011
How do we capture 15 years of complex and meaningful data about young people's lives?

New Zealand Journal of Social Sciences Online: Kotuitui, 2011, 6(6), 37-49.
http://www.tandfonline.com/doi/abs/10.1080/1177083X.2011.614624
Our ref: NZ93

Show abstract » This paper describes the development of a method of data collection, which captures the complexity of living situations, family dynamics and key life events of teenagers. This Life History Calendar was adapted from earlier life history calendar methods for a multidisciplinary intergenerational study. The new calendar is able to record details of 15 years of teenage participants lives and can be administered to teenagers and their parents to show changes over individual lives and difference between individuals in a cohort. Referring to some preliminary data, we show that the calendar is a practical and effective method of data collection, which will be useful to researchers and practitioners working with young people and their families.
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Uher, R., Caspi, A., Houts, R., Sugden, K., Williams, B.S., Poulton, R. , Moffitt, T.E. | 2011
Serotonin transporter gene moderates childhood maltreatment's effects on persistent but not single-episode depression: Replications and implications for resolving inconsistent results

Journal of Affective Disorders, 2011, 135(135), 56-65.
http://www.sciencedirect.com/science/article/pii/S0165032711000930
Our ref: RO616

Show abstract » Objective: To investigate whether subtypes of depression predict differential outcomes of treatment with selective serotonin-reuptake inhibitor (SSRI) and a tricyclic antidepressant in major depression. Method: Among 811 adults with moderate-to-severe depression, melancholic, atypical, anxious and anxious-somatizing depression subtypes established at baseline were evaluated as predictors of outcome of treatment with flexible dosage of the SSRI escitalopram or the tricyclic antidepressant nortriptyline. The primary outcome measure was the Montgomerysberg Depression Rating Scale (MADRS). Secondary outcome measures were the 17-item Hamilton Rating Scale for Depression (HRSD-17) and the Beck Depression Inventory (BDI). Results: Melancholic depression was associated with slightly worse outcomes among individuals treated with escitalopram, but did not affect outcome of treatment with nortriptyline. The interaction between melancholic depression and drug did not reach statistical significance for the primary outcome measure and significant results for secondary outcome measures were not robust in sensitivity analyses. Atypical depression was unrelated to outcome of treatment with either antidepressant. Anxious and anxious-somatizing depression did not predict outcome on the primary measure, but inconsistently predicted worse outcome in some secondary analyses. Limitations: Some participants were non-randomly allocated to drug. Therefore, drug-bypredictor interactions had to be validated in sensitivity analyses restricted to the 468 randomly allocated individuals. Conclusions: Melancholic, atypical or anxious depression, are not sufficiently robust differential predictors of outcome to help clinician choose between SSRI and tricyclic antidepressants. There is a need to investigate other predictors of outcome.
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Nada-Raja, S. , Skegg, K. M. | 2011
Victimization, posttraumatic stress disorder symptomatology and later non-suicidal self-harm in a birth cohort

Journal of Interpersonal Violence, 2011, 26(26), 36673681.
DOI: 10.1177/0886260511403757 http://jiv.sagepub.com/content/26/18/3667.full.pdf+html
Our ref: RO614

Show abstract » This longitudinal population-based study examined pathways to nonsuicidal self-harm (NSSH) in relation to childhood sexual abuse (CSA), assault victimization in early adulthood, posttraumatic stress disorder symptomatology (PTSD), and other mental disorders. At age 21,476 men and 455 women completed interviews on assaultvictimization, PTSD, andother mental disorders. At age 26, they completed independent interviews on self-harm and childhood sexual abuse (CSA). Multivariate logistic regression analyses were conducted to determine predictors for NSSH at age 26. For men, anxiety and depressive disorders at age 21 were the only significant predictors of NSSH at age 26. For women, victimization, PTSD, and other anxiety disorders at age 21 all significantly predicted NSSH. CSA predicted later NSSH only indirectly, by increasing the risk of anxiety disorders among men and of assault victimization among women. In conclusion, pathways to nonsuicidal self-harm differed by sex. For women there were direct links with assault victimization and PTSD in early adulthood, whereas for men only internalizing disorders predicted future NSSH.
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Peres, M.A., Thomson, W. M. , Peres, K.G., Gigante, D.P., Horta, B.L., Broadbent, J. M. , Poulton, R. | 2011
Challenges in comparing the methods and findings of cohort studies of oral health: the Dunedin (New Zealand) and Pelotas (Brazil) studies

Australian and New Zealand Journal of Public Health, 2011, 35(35), 549-556.
http://onlinelibrary.wiley.com/doi/10.1111/j.1753-6405.2011.00736.x/abstract
Our ref: RO613

Show abstract » Objective: to systematically compare methods and some findings from two prospective cohort studies of oral health. Methods : This paper describes and compares two such population-based birth cohort studies of younger adults: the Dunedin Multidisciplinary Health and Development Study (conducted in New Zealand); and the 1982 Pelotas Birth Cohort Study (conducted in Brazil). Results: The two cohorts showed socio-demographic similarities and differences, with their gender mixes being similar, but their ethnic compositions differing markedly. There were some important similarities and differences in methods. Overall dental caries experience was higher among the Dunedin cohort. Each of the studies has examined the association between childhood-adulthood changes in socio-economic status and oral health in the mid-20s. Both studies observed the greatest disease experience among those who were of low SES in both childhood and adulthood, and the least among those who were of high SES in both childhood and adulthood. In each cohort, disease experience in the upwardly mobile and downwardly mobile groups lay between those two extremes. Conclusions and implications: There are important similarities and differences in both methods and findings. While the need for a degree of methodological convergence in future is noted, the two studies are able to use each other as replicate samples for research into chronic oral conditions.
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Lee, M.H.S., Hancox, R. J. | 2011
Effects of smoking cannabis on lung function

Expert Review of Respiratory Medicine, 2011, 5(5), 537-547.
http://www.expert-reviews.com/doi/abs/10.1586/ers.11.40
Our ref: RO612

Show abstract » Although cannabis (or marijuana) is the worlds most widely-used illicit drug, there has been surprisingly little research into its effects on respiratory health. Part of the problem is the inherent difficulty of studying the long-term effects of an illegal habit. It has often been assumed that smoking cannabis will have similar long-term effects to smoking tobacco. Several recent observational studies suggest that this is not the case and that cannabis has quite different effects on the lung function. There are consistent findings that smoking cannabis is associated with large airway inflammation, symptoms of bronchitis, increased airway resistance and lung hyperinflation. The evidence that smoking cannabis leads to features of chronic obstructive pulmonary disease, such as airflow obstruction and emphysema is not convincing. However, there are numerous case reports of bullous emphysema among cannabis smokers. These findings have not been confirmed in systematic analytical studies and probably represent uncommon adverse effects in very heavy cannabis smokers. There is now additional controversial evidence that cannabis is at least an occasional cause of respiratory malignancies, but again the evidence is inconclusive.
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Hancox, R. J. , Landhuis, C.E. | 2011
Association between sleep duration and haemoglobin A1c in young adults

Journal of Epidemiology and Community Health, 2011, Online First, doi:10.1136/jech-2011-200217.
Our ref: RO611

Show abstract » Background: Epidemiological and experimental evidence suggests that inadequate sleep can cause both obesity and impaired glucose tolerance. Short sleep duration in childhood appears to have a greater impact on the risk for adult obesity than adult sleep duration. The long-term effects of childhood sleep on glucose metabolism have not been investigated. The authors assessed the associations between childhood and adult sleep duration and adult glycosylated haemoglobin (HbA1c) levels. Methods: An unselected cohort of 1037 individuals, born in Dunedin, New Zealand, between 1972 and 1973. Parent reports of times in bed at ages 5, 7, 9 and 11 were used to estimate childhood sleep duration. Adult sleep duration was estimated from self-reported times in bed at age 32. HbA1c levels were measured at age 32. Pregnant women and participants with diabetes were excluded from the analyses. Results: Childhood sleep duration did not predict adult HbA1c. However, less time spent in bed at age 32 was associated with higher levels of HbA1c (p=0.002) and an increased risk of prediabetes (p=0.015). The inverse association between adult sleep times and HbA1c was independent of body mass index, smoking, socioeconomic status, shift work and symptoms of obstructive sleep apnoea. Conclusions: Short sleep duration is associated with higher levels of HbA1c and an increased risk of prediabetes in young adults. The findings suggest that inadequate sleep impairs glucose control in the short term and may increase the risk for long-term health problems.
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Thomson, W. M. , Caspi, A., Poulton, R. , Moffitt, T.E., Broadbent, J. M. | 2011
Personality and oral Health

European Journal of Oral Science, 2011, 119(119), 366-372.
Our ref: RO610

Show abstract » We investigated age-26 personality characteristics and age-32 oral health in a prospective study of a complete birth cohort born in Dunedin, New Zealand. Personality was measured using the Multidimensional Personality Questionnaire (MPQ). Oral health was measured using the short-form Oral Health Impact Profile (OHIP-14), a global measure, and dental examinations. Personality profiles were constructed for 916 individuals (50.8% men) using standardized MPQ scores, and multivariate analyses examined their association with oral health. Those reporting 1+ OHIP-14 impacts had higher Negative Emotionality scores (and lower Constraint and Positive Emotionality MPQ superfactor scores) than those who did not. After controlling for gender, clinical status, and the other two MPQ superfactors, those scoring higher on Negative Emotionality had a greater risk of reporting 1+ OHIP-14 impacts, as well as 3+ OHIP-14 impacts and worse-than-average oral health. They also had a greater risk of having lost at least one tooth from caries and of having 3+ decayed surfaces. Personality characteristics appear to shape self-reports of oral health. Personality is also a risk factor for clinical disease status, at least with respect to dental caries and its sequelae. Because the attitudes and values tapped into by personality tests can be altered by brief cognitive interventions, those might be useful in preventive dentistry.
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Shearer, D.M., Thomson, W. M. , Broadbent, J. M. , Poulton, R. | 2011
Does maternal oral health predict child oral health-related quality of life in adulthood?

Health & Quality of Life Outcomes, 2011, 9(9), 50-57.
http://www.hqlo.com/content/9/1/50/abstract
Our ref: RO609

Show abstract » BACKGROUND: A parental/family history of poor oral health may influence the oral-health-related quality of life (OHRQOL) of adults. Objectives: To determine whether the oral health of mothers of young children can predict the OHRQOL of those same children when they reach adulthood. METHODS: Oral examination and interview data from the Dunedin Study's age-32 assessment, as well as maternal self-rated oral health data from the age-5 assessment were used. The main outcome measure was study members' short-form Oral Health Impact Profile (OHIP-14) at age 32. Analyses involved 827 individuals (81.5% of the surviving cohort) dentally examined at both ages, who also completed the OHIP-14 questionnaire at age 32, and whose mothers were interviewed at the age-5 assessment. RESULTS: There was a consistent gradient of relative risk across the categories of maternal self-rated oral health status at the age-5 assessment for having one or more impacts in the overall OHIP-14 scale, whereby risk was greatest among the study members whose mothers rated their oral health as poor/edentulous, and lowest among those with an excellent/fairly good rating. In addition, there was a gradient in the age-32 mean OHIP-14 score, and in the mean number of OHIP-14 impacts at age 32 across the categories of maternal self-rated oral health status. The higher risk of having one or more impacts in the psychological discomfort subscale, when mother rated her oral health as poor/edentulous, was statistically significant. CONCLUSIONS: These data suggest that maternal self-rated oral health when a child is young has a bearing on that child's OHRQOL almost three decades later. The adult offspring of mothers with poor self-rated oral health had poorer OHRQOL outcomes, particularly in the psychological discomfort subscale.
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Grisham, J. R. , Fullana, M. A. , Mataix-Cols, D. , Moffitt, T.E., Caspi, A., Poulton, R. | 2011
Risk factors prospectively associated with adult obsessive-compulsive symptom dimensions and obsessive-compulsive disorder

Psychological Medicine, 2011, 41(41), 2495-2506.
www.ncbi.nlm.nih.gov/pubmed/21672296
Our ref: RO608

Show abstract » BACKGROUND: Very few longitudinal studies have evaluated prospective neurodevelopmental and psychosocial risk factors for obsessive-compulsive disorder (OCD). Furthermore, despite the heterogeneous nature of OCD, no research has examined risk factors for its primary symptom dimensions, such as contamination/washing.Method: Potential risk factors for symptoms or diagnosis of OCD in adulthood and for specific adult obsessive-compulsive (OC) symptom dimensions were examined in the Dunedin Study birth cohort. The presence of obsessions and compulsions and psychological disorders was assessed using the Diagnostic Interview Schedule (DIS) at ages 26 and 32 years. Individuals with a diagnosis of OCD at either age (n=36) were compared to both a healthy control group (n=613) and an anxious control group (n=310) to determine whether associations between a risk factor and an OCD diagnosis were specific. RESULTS: Childhood neurodevelopmental, behavioral, personality and environmental risk factors were associated with a diagnosis of OCD and with OC symptoms at ages 26 and 32. Social isolation, retrospectively reported physical abuse and negative emotionality were specific predictors of an adult OCD diagnosis. Of note, most risk factors were associated with OC symptoms in adulthood and several risk factors predicted specific OCD dimensions. Perinatal insults were linked to increased risk for symmetry/ordering and shameful thoughts dimensions, whereas poor childhood motor skills predicted the harm/checking dimension. Difficult temperament, internalizing symptoms and conduct problems in childhood also predicted specific symptom dimensions and lower IQ non-specifically predicted increased risk for most dimensions. CONCLUSIONS: The current findings underscore the need for a dimensional approach in evaluating childhood risk factors for obsessions and compulsions.
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Brookland, R. , Begg, D. J. | 2011
Adolescent, and their parents, attitudes towards graduated driver licensing and subsequent risky driving and crashes in young adulthood

Journal of Safety Research, 2011, 42(42), 109-115.
http://www.sciencedirect.com/science/journal/00224375
Our ref: RO607

Show abstract » Problem: Although Graduated Driver Licensing Systems (GDLS) have helped reduce young driver crash rates, they remain significantly over-represented in crash statistics. To be effective GDLS rely heavily on support for the legislation by those directly involved; parents to enforce the restrictions and adolescents to comply. There is some evidence that practices regarding GDLS restrictions influence adolescent driving outcomes in the early stage of licensure. However there has been no examination undertaken on the influence of parent and adolescent attitudes toward GDLS on adolescents driving behavior and crash experiences as they move into their young adult years. The aim of this research was to examine these relationships. Method: This investigation was based on a longitudinal study of a birth cohort, and uses data collected when the cohort members were aged 15, 18, and 21years. At age 15 both adolescent and their parent attitudes toward GDLS were measured. At age 18 adolescent GDLS attitudes were measured again. The association between these measures and self-reported risky driving behavior and crash involvement at age 21 were examined. Results: Negative attitudes toward the learner supervisor restriction for males, and negative attitudes toward a GDLS for females were strongly associated with risky driving and crash involvement as young adults. Impact on industry: Targeting interventions to improve adolescents and parents understanding of the reasons for graduated licensing and the specific restrictions may improve attitudes and views and thereby contribute to a reduction in risky driving behaviors and crash risk among young adults.
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Broadbent, J. M. , Thomson, W. M. , Boyens, J.V., Poulton, R. | 2011
Dental plaque and oral health during the first 30 years of life

Journal of the American Dental Association, 2011, 142(142), 415-426.
http://jada.ada.org/cgi/content/full/142/4/415
Our ref: RO606

Show abstract » BACKGROUND: Studies investigating the role of dental plaque in oral disease have focused primarily on the quantity and quality of plaque at a given point in time. No large-scale epidemiologic research has been conducted regarding the continuity and change in plaque levels across the long term and the association of plaque levels with oral health. METHODS: The authors used data from the Dunedin Multidisciplinary Health and Development Study. Collection of dental plaque data occurred at ages 5, 9, 15, 18, 26 and 32 years by means of the Simplified Oral Hygiene Index. The authors assessed oral health outcomes when participants were aged 32 years. Figure 1Plaque trajectory group plots. Simplified Oral Hygiene Index (OHI-S) plaque scores, according to age. RESULTS: The authors identified three plaque trajectory groups (high, n = 357; medium, n = 450; and low; n = 104) and found substantial, statistically significant differences in both caries and periodontal disease experience among those groups. For example, after the authors controlled for sex, socioeconomic status and dental visiting pattern, they found that participants in the high-plaque-trajectory group lost nearly five times more teeth owing to caries than did those in the low-plaque-trajectory group. CONCLUSIONS: Across the long term, participants in the high-plaque-trajectory group were more likely to experience caries, periodontal disease and subsequent tooth loss than were those in the low- or medium-plaque-trajectory groups, and they experienced all those conditions with greater severity. CLINICAL IMPLICATIONS: Improving oral health requires emphasizing long-term self-care, as well as providing broad public health and health promotion measures that promote and support oral self-care. This study's findings suggest that poor oral hygiene and smoking have a synergistic effect on periodontal disease experience.
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Shearer, D.M., Thomson, W. M. , Broadbent, J. M. , Poulton, R. | 2011
Maternal oral health predicts their children

Journal of Dental Research, 2011, 90(90), 672-677.
http://jdr.sagepub.com/content/90/5/672
Our ref: RO605

Show abstract » The long-term effects of poor maternal oral health are unknown. We determined whether maternal oral health when children were young was a risk indicator for caries experience in adulthood, using oral examination and interview data from age-5 and age-32 assessments in the Dunedin Study, and maternal self-rated oral health data from the age-5 assessment. The main outcome measure was probands caries status at age 32. Analyses involved 835 individuals (82.3% of the surviving cohort) dentally examined at both ages, whose mothers were interviewed at the age-5 assessment. There was a consistent gradient in age-32 caries experience across the categories of maternal self-rated oral health status (from the age-5 assessment): it was greatest among the probands whose mothers rated their oral health as poor or who were edentulous, and lowest among those whose mothers rated their oral health as excellent. Unfavorable maternal self-rated oral health when children are young should be regarded as a risk indicator for poor oral health among offspring as they reach adulthood.
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Shearer, D.M., Thomson, W. M. , Caspi, A., Moffitt, T.E., Broadbent, J. M. , Poulton, R. | 2011
Intergenerational continuity in periodontal health: findings from the Dunedin Study

Journal of Clinical Periodontology, 2011, 38(38), 301-309.
DOI: 10.1111/j.1600-051X.2010.01687.x
Our ref: RO604

Show abstract » Objective: To determine whether parental periodontal disease history is a risk factor for periodontal disease in adult offspring. Methods: Proband periodontal examination [combined attachment loss (CAL) at age 32, and incidence of CAL from ages 26 to 32] and interview data were collected during the age-32 assessments in the Dunedin Study. Parental data were also collected. The sample was divided into two familial-risk groups for periodontal disease (high- and low-risk) based on parents self-reported periodontal disease. Results: Periodontal risk analysis involved 625 proband-parent(s) groups. After controlling for confounding factors, the high-familial-risk periodontal group was more likely to have 11 sites with 41mm CAL [relative risk (RR) 1.45; 95% confidence interval (CI) 1.111.88], 21 sites with 41mm CAL (RR 1.45; 95% CI 1.032.05), 11 sites with 51mm CAL (RR 1.60; 95% CI 1.022.50), and 11 sites with 31mm incident CAL (RR 1.64; 95% CI 1.012.66) than the low-familial-risk group. Predictive validity was enhanced when information was available from both parents. Conclusions: Parents with poor periodontal health tend to have offspring with poor periodontal health. Family/parental history of oral health is a valid representation of the shared genetic and environmental factors that contribute to an individuals periodontal status, and may help to predict patient prognosis and preventive treatment need.
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Crocombe, L. A. , Broadbent, J. M. , Thomson, W. M. , Brennan, D. S. , Slade, G. D. , Poulton, R. | 2011
Dental visiting trajectory patterns and their antecedents

Journal of Public Health Dentistry, 2011, 71(71), 23-31.
http://onlinelibrary.wiley.com/doi/10.1111/j.1752-7325.2010.00196.x/full
Our ref: RO603

Show abstract » Objective: This study aimed to test whether socioeconomic status (SES) in childhood may affect dental visiting patterns between ages 18 and 32 years. Methods: Using data from a complete birth cohort, childhood SES status was measured (using the New Zealand Elley-Irving index) at each study stage between birth and 15 years. Longitudinal dental visiting data were available for 833 study participants from ages 15, 18, 26, and 32, and these were analyzed by trajectory analysis. Results: Three separate dental visiting trajectories were identified; these were categorized as opportunists (13.1%), decliners (55.9%),and routine attenders (30.9%). Bivariate analyses showed low SES in childhood, male sex, and dental anxiety to be associated with membership of the opportunist dental visiting trajectory. Multinomial logistic regression showed that low childhood SES and dental anxiety were statistically significant predictors for membership in the opportunist or decliner trajectories after accounting for potential confounding variables. Conclusion: Individuals who grew up experiencing low childhood SES were less likely to adopt a routine dental visiting trajectory in adulthood than those with a high childhood SES. Dental anxiety was also an important predictor of dental visiting patterns.
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Moffitt, T.E., Arseneault, L. , Belsky, D.W., Dickson, N., Hancox, R. J. , Harrington, H. L., Houts, R., Poulton, R. , Roberts, B.W., Ross, S., Sears, M.R., Thomson, W. M. , Caspi, A. | 2011
A gradient of childhood self-control predicts health, wealth, and public safety

PNAS (Proceedings of the National Academy of Sciences of the USA), 2011, 108(108), 2693-2698.
doi:10.1073/pnas.1010076108
Our ref: RO602

Show abstract » Policy-makers are considering large-scale programs aimed at self-control to improve citizens' health and wealth and reduce crime. Experimental and economic studies suggest such programs could reap benefits. Yet, is self-control important for the health, wealth, and public safety of the population? Following a cohort of 1,000 children from birth to the age of 32 y, we show that childhood self-control predicts physical health, substance dependence, personal finances, and criminal offending outcomes, following a gradient of self-control. Effects of children's self-control could be disentangled from their intelligence and social class as well as from mistakes they made as adolescents. In another cohort of 500 sibling-pairs, the sibling with lower self-control had poorer outcomes, despite shared family background. Interventions addressing self-control might reduce a panoply of societal costs, save taxpayers money, and promote prosperity.
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Dawes, P. J., Welch, D. | 2010
Childhood hearing and its relationship with Tinnitus at thirty-two years of age

Annals of Otology, Rhinology & Laryngology, 2010, 119(119), 672-676.
Our ref: RO601.2

Show abstract » Objectives: Tinnitus is associated with hearing loss in adulthood, often resulting from noise or age, but it is not known whether children's hearing and/or middle ear health predispose them to tinnitus in adulthood. Methods: The participants were members of the Dunedin Multidisciplinary Health and Development Study, born in Dunedin, New Zealand, between April 1972 and March 1973. The base sample consisted of 1,037 children. Otitis media was assessed at 5,7, and 9 years of age; audiometry and tympanometry findings were recorded at 11 years of age, and a detailed description of the tympanic membrane was made at 15 years of age. At 32 years of age, 970 of the 1,015 living study members (96%) answered questions about tinnitus. Results: Children who had otitis media and a raised audiometric threshold went on to experience more tinnitus in adulthood than did those without middle ear disease or those who had otitis media without a raised threshold. In those who had recovered from otitis media, audiometric threshold elevation at lower and higher frequencies was associated with experiencing tinnitus in adulthood. Neither childhood otitis media alone nor elevated thresholds alone predicted adult tinnitus. Conclusions: Childhood otitis media with an associated hearing loss in the low and high frequencies was associated with a greater probability of experiencing tinnitus in adulthood.
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Poulton, R., Moffitt, T.E. | 2010
The Dunedin Multidisciplinary Health and Development Study: tips and traps from a 40-year longitudinal study

International Journal of Behavioural Development, 2010, 34(34), 18-21.
Our ref: RO601

Show abstract » Overview of DMHDS - research strategy, research findings, sample retention strategies, challenges for launching new longitudinal research.
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Welch, D., McGee, R. | 2010
Breath holding predicts reduced smoking intake but not quitting

Open Addiction, 2010, 3(3), 39-42.
Our ref: RO600

Show abstract » Introduction: Cigarette smokers who attempt to quit may or may not relapse. Previous research has shown that breath-holding ability predicts successful quitting, and it has been suggested that breath-holding ability may be a marker of tolerance for uncomfortable physiological symptoms. Methods: We measured breath-holding ability and smoking in a large general-population birth cohort from age 21 to age 32. Results: Cross-sectionally, at age 21, breath-holding ability was greater in males who had quit smoking than in either current or non-smokers, while no such differences were observed amongst females. On the other hand, no prospective associations were detected between breath-holding ability and quitting smoking by age 32. Pack years smoked was lower amongst male smokers with better breath-holding ability at age 32. Discussion: While the cross-sectional finding in males was consistent with the hypothesis that those with more tolerance for breath holding would be more successful at quitting, there was no long-term effect to age 32. On the other hand, breath-holding was associated with reduced intake over time in males. A behavioural mechanism whereby longer breath holders smoke less because of a greater tolerance for the physical discomfort associated with intervals between cigarettes is consistent with these findings.
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Skegg, K. M., Nada-Raja, S. , Dickson, N. , Paul, C. | 2010
Perceived out of control sexual behavior in a cohort of young adults from the Dunedin Multidisciplinary Health and Development Study

Archives of Sexual Behaviour, 2010, 39(39), 968-78.
www.ncbi.nlm.nih.gov/pubmed/19421850
Our ref: RO599

Show abstract » Out of control sexual behavior, also known as compulsive sexual behavior or sexual addiction, has not been studied in a representative sample of the general population. At age 32 years, 940 (93%) of 1,015 members of the birth cohort of the Dunedin Multidisciplinary Health and Development Study responded to a series of questions about sexual behavior, administered by computer. We enquired about sexual fantasies, urges or behavior that participants regarded as out of control during the previous year, and defined such experiences as out of control sexual experiences (OCSE). Nearly 13% of men and 7% of women reported OCSE in the past year. Women who reported such experiences were more likely than other women to have reported (elsewhere in the interview) having had high numbers of opposite sex partners, concurrent sexual relationships, or sex with a partner met on the internet, as well as a higher likelihood of same-sex attraction or behavior. Among men reporting OCSE, there was an association with having paid for heterosexual sex and with same-sex attraction and behavior. Few believed that OCSE had interfered with their lives (3.8% of all men and 1.7% of all women in the cohort). Only 0.8% of men and 0.6% of women reported that their actual sexual behavior had interfered with their lives. OCSE were also analyzed in relation to certain personality traits and to childhood sexual abuse (CSA). Some evidence of a link with impulsivity (women only) and negative affectivity was found. CSA was associated with OCSE among men. In conclusion, this population-based study has provided the first empirical estimations of the occurrence of OCSE and its relationship to a range of sexual behaviors in a representative sample.
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Bell, M.L., van Roode, T., Dickson, N., Jang, Z., Paul, C. | 2010
Consistency and reliability of self-reported lifetime number of heterosexual partners by gender and age in a cohort study

Sexually Transmitted Diseases, 2010, 37(37), 425-431.
DOI: 10.1097/OLQ.0b013e3181d13ed8
Our ref: RO598

Show abstract » BACKGROUND:: The reported number of sexual partners is a variable used extensively in sexual health research. However, the reliability and consistency of this measure, and the statistical assessment of these attributes, are not well understood. METHODS:: Using data at ages 21, 26, and 32 years from a New Zealand birth cohort, we compared responses on the lifetime number of heterosexual sex partners to assess reliability and consistency. Differences by gender and age were considered, and the effect of number of sexual partners. A variety of analytical methods were used to explore statistical challenges of these data including variance estimation, fractional polynomial transformations, and quantile regression. RESULTS:: We found some level of discrepancy between reports of the number of sexual partners when assessed at different times is common, driven by those reporting a high number of partners who were disproportionately men. Men reported a higher lifetime number of partners than women at each age, and there were statistically significant differences by gender in (a) consistency between reports at different ages, and (b) reliability of reports as measured by both the Intraclass Correlation Coefficient and the Kappa statistic. CONCLUSIONS:: When considering reliability, multiple statistical approaches are necessary or conclusions can be misleading. Variance components should be examined when considering the Intraclass Correlation Coefficient. When modelling, robust methods like fractional polynomials and quantile regression should be employed to accommodate nonlinearity. Sensitivity analyses excluding participants whose partner number is in the upper 5% to 25% are informative, as these were shown to have the highest discrepancies.
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Richards, R., McGee, R., Williams, S.M., Welch, D. , Hancox, R. J. | 2010
Adolescent screen-time and attachment to parents and peers

Archives of Pediatrics & Adolescent Medicine, 2010, 164(164), 258-262.
Our ref: RO597

Show abstract » Objective: To examine associations between screen-time (television, video/DVD, gaming, computer use) and attachment to parents and peers in two cohorts of adolescents, 16 years apart. Design: Cross-sectional data regarding screen-time and attachment to parents and peers were collected for two cohorts of adolescents, one in 1987/88 (Dunedin Multidisciplinary Health and Development cohort, DMHDS) and one in 2004 (Youth Lifestyle Study cohort, YLS). Setting: Members of the DMHDS cohort were interviewed as part of a full day of assessment and members of the YLS cohort completed a self-report questionnaire in a supervised classroom setting. Participants: The DMHDS cohort (n = 976 at age 15) was aged 15 years in 1987/88. The YLS cohort (n = 3043) was aged 14 and 15 years in 2004. Main outcome measures: Low attachment to parents and peers as measured by the Inventory of Parent and Peer attachment. Results: More time spent television viewing and less time reading and doing homework were associated with low parent attachment for both cohorts. Among the YLS cohort, more time playing on a computer was also associated with low parent attachment. Among the DMHDS cohort, greater television viewing was associated with low peer attachment. Conclusion: Screen-time was associated with poor attachment to parents and peers in two cohorts of adolescents, 16 years apart. Given the importance of parental and peer attachment to adolescent health and development, concern about high levels of screen-time among adolescents is warranted.
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Thomson, W. M. , Williams, S.M., Broadbent, J. M. , Poulton, R. , Locker, D. | 2010
Long-term dental visiting patterns and adult oral health

Journal of Dental Research, 2010, 89(89), 307-311.
www.ncbi.nlm.nih.gov/pubmed/20093674
Our ref: RO596

Show abstract » To date, the evidence supporting the benefits of dental visiting comes from cross-sectional studies. We investigated whether long-term routine dental visiting was associated with lower experience of dental caries and missing teeth, and better self-rated oral health, by age 32. A prospective cohort study in New Zealand examined 932 participants' use of dentistry at ages 15, 18, 26, and 32. At each age, routine attenders (RAs) were identified as those who (a) usually visited for a check-up, and (b) had made a dental visit during the previous 12 months. Routine attending prevalence fell from 82% at age 15 to 28% by 32. At any given age, routine attenders had better-than-average oral health, fewer had teeth missing due to caries, and they had lower mean DS and DMFS scores. By age 32, routine attenders had better self-reported oral health and less tooth loss and caries. The longer routine attendance was maintained, the stronger the effect. Routine dental attendance is associated with better oral health.
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Reichenberg, A., Caspi, A. , Harrington, H. L., Houts, R., Keefe, R., Murray, R. M., Poulton, R. , Moffitt, T. E. | 2010
Static and dynamic cognitive deficits in childhood preceding adult schizophrenia: a 30-year study

American Journal of Psychiatry, 2010, 167(167), 160-169.
www.ncbi.nlm.nih.gov/pubmed/20048021
Our ref: RO595

Show abstract » OBJECTIVE: Premorbid cognitive deficits in schizophrenia are well documented and have been interpreted as supporting a neurodevelopmental etiological model. The authors investigated the following three unresolved questions about premorbid cognitive deficits: What is their developmental course? Do all premorbid cognitive deficits follow the same course? Are premorbid cognitive deficits specific to schizophrenia or shared by other psychiatric disorders? METHOD: Participants were members of a representative cohort of 1,037 males and females born between 1972 and 1973 in Dunedin, New Zealand. Cohort members underwent follow-up evaluations at specific intervals from age 3 to 32 years, with a 96% retention rate. Cognitive development was analyzed and compared in children who later developed schizophrenia or recurrent depression as well as in healthy comparison subjects. RESULTS: Children who developed adult schizophrenia exhibited developmental deficits (i.e., static cognitive impairments that emerge early and remain stable) on tests indexing verbal and visual knowledge acquisition, reasoning, and conceptualization. In addition, these children exhibited developmental lags (i.e., growth that is slower relative to healthy comparison subjects) on tests indexing processing speed, attention, visual-spatial problem solving ability, and working memory. These two premorbid cognitive patterns were not observed in children who later developed recurrent depression. CONCLUSIONS: These findings suggest that the origins of schizophrenia include two interrelated developmental processes evident from childhood to early adolescence (ages 7-13 years). Children who will grow up to develop adult schizophrenia enter primary school struggling with verbal reasoning and lag further behind their peers in working memory, attention, and processing speed as they get older.
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Hancox, R. J. , Poulton, R., Ely, M., Welch, D., Taylor, D. R. , McLachlan, C. R. , Greene, J. M. , Moffitt, T. E. , Caspi, A., Sears, M.R. | 2010
Effects of cannabis on lung function: a population-based cohort study

European Respiratory Journal, 2010, 35(35), 42-47.
Our ref: RO594

Show abstract » The effects of cannabis on lung function remain unclear and may be different to tobacco. We compared the associations between use of these substances and lung function in a population-based cohort (n=1037). Cannabis and tobacco use were reported at ages 18, 21, 26, and 32 years. Spirometry, plethysmography, and carbon monoxide transfer factor were measured at age 32. Associations between lung function and exposure to each substance were adjusted for exposure to the other substance. Cumulative cannabis use was associated with higher forced vital capacity, total lung capacity, functional residual capacity, and residual volume. Cannabis was also associated with higher airways resistance but not with forced expiratory volume in 1 second, forced expiratory ratio, or transfer factor. These findings were similar amongst those who did not smoke tobacco. By contrast, tobacco use was associated with lower forced expiratory volume in 1 second, lower forced expiratory ratio, lower transfer factor, and higher static lung volumes, but not with airways resistance. Cannabis appears to have different effects on lung function to those of tobacco. Cannabis use was associated with higher lung volumes suggesting hyperinflation and increased large-airways resistance, but there was little evidence for airflow obstruction or impairment of gas transfer.
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Moffitt, T.E., Caspi, A., Taylor, A., Kokaua, J./Milne, B.J., Polanczyk, G., Poulton, R. | 2010
How common are common mental disorders? Evidence that lifetime prevalence rates are doubled by prospective versus retrospective ascertainment

Psychological Medicine, 2010, 40(40), 899-909.
doi:10.1017/S0033291709991036
Our ref: RO589

Show abstract » BACKGROUND: Most information about the lifetime prevalence of mental disorders comes from retrospective surveys, but how much these surveys have undercounted due to recall failure is unknown. We compared results from a prospective study with those from retrospective studies.MethodThe representative 1972-1973 Dunedin New Zealand birth cohort (n=1037) was followed to age 32 years with 96% retention, and compared to the national New Zealand Mental Health Survey (NZMHS) and two US National Comorbidity Surveys (NCS and NCS-R). Measures were research diagnoses of anxiety, depression, alcohol dependence and cannabis dependence from ages 18 to 32 years. RESULTS: The prevalence of lifetime disorder to age 32 was approximately doubled in prospective as compared to retrospective data for all four disorder types. Moreover, across disorders, prospective measurement yielded a mean past-year-to-lifetime ratio of 38% whereas retrospective measurement yielded higher mean past-year-to-lifetime ratios of 57% (NZMHS, NCS-R) and 65% (NCS). CONCLUSIONS: Prospective longitudinal studies complement retrospective surveys by providing unique information about lifetime prevalence. The experience of at least one episode of DSM-defined disorder during a lifetime may be far more common in the population than previously thought. Research should ask what this means for etiological theory, construct validity of the DSM approach, public perception of stigma, estimates of the burden of disease and public health policy.
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Danese, A. , Moffitt, T. E. , Harrington, H. L., Milne, B. J. , Polanczyk, G., Pariante, C.M., Poulton, R. , Caspi, A. | 2009
Adverse childhood experiences and adult risk factors for age-related disease: depression, inflammation, and clustering of metabolic risk markers

Archives of Pediatrics & Adolescent Medicine, 2009, 163(163), 1135-1143.
www.ncbi.nlm.nih.gov/pubmed/19996051
Our ref: RO593

Show abstract » OBJECTIVE: To understand why children exposed to adverse psychosocial experiences are at elevated risk for age-related disease, such as cardiovascular disease, by testing whether adverse childhood experiences predict enduring abnormalities in stress-sensitive biological systems, namely, the nervous, immune, and endocrine/metabolic systems. DESIGN: A 32-year prospective longitudinal study of a representative birth cohort. SETTING: New Zealand. PARTICIPANTS: A total of 1037 members of the Dunedin Multidisciplinary Health and Development Study. Main Exposures During their first decade of life, study members were assessed for exposure to 3 adverse psychosocial experiences: socioeconomic disadvantage, maltreatment, and social isolation. MAIN OUTCOME MEASURES: At age 32 years, study members were assessed for the presence of 3 age-related-disease risks: major depression, high inflammation levels (high-sensitivity C-reactive protein level >3 mg/L), and the clustering of metabolic risk biomarkers (overweight, high blood pressure, high total cholesterol, low high-density lipoprotein cholesterol, high glycated hemoglobin, and low maximum oxygen consumption levels. RESULTS: Children exposed to adverse psychosocial experiences were at elevated risk of depression, high inflammation levels, and clustering of metabolic risk markers. Children who had experienced socioeconomic disadvantage (incidence rate ratio, 1.89; 95% confidence interval, 1.36-2.62), maltreatment (1.81; 1.38-2.38), or social isolation (1.87; 1.38-2.51) had elevated age-related-disease risks in adulthood. The effects of adverse childhood experiences on age-related-disease risks in adulthood were nonredundant, cumulative, and independent of the influence of established developmental and concurrent risk factors. CONCLUSIONS: Children exposed to adverse psychosocial experiences have enduring emotional, immune, and metabolic abnormalities that contribute to explaining their elevated risk for age-related disease. The promotion of healthy psychosocial experiences for children is a necessary and potentially cost-effective target for the prevention of age-related disease.
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Ioannidis, J.P.A., Loy, E.Y., Poulton, R., Chia, K.S. | 2009
Researching genetic versus nongenetic determinants of disease: A comparison and proposed unification

Science Translational Medicine, 2009, 1(1), 7ps8.
doi: 10.1126/scitranslmed.3000247
Our ref: RO592.2

Show abstract » Research standards deviate in genetic versus nongenetic epidemiology. Besides some immutable differences, such as the correlation pattern between variables, these divergent research standards can converge considerably. Current research designs that dissociate genetic and nongenetic measurements are reaching their limits. Studies are needed that massively measure genotypes, nongenetic exposures, and outcomes concurrently.
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Hancox, R. J. , Poulton, R. , Welch, D. , Olova, N. , McLachlan, C. R. , Greene, J. M. , Sears, M. R. , Caspi, A. , Moffitt, T. E. , Robertson, S. P. , Braithwaite, A. W. | 2009
Accelerated decline in lung function in cigarette smokers is associated with TP53/MDM2 polymorphisms

Human Genetics, 2009, 126(126), 559-565.
www.ncbi.nlm.nih.gov/pubmed/19521721/1432-1203 (Electronic)
Our ref: RO592

Show abstract » In vitro studies have shown that p53 mediates a protective response against DNA damage by causing either cell-cycle arrest and DNA repair, or apoptosis. These responses have not yet been demonstrated in humans. A common source of DNA damage in humans is cigarette smoke, which should activate p53 repair mechanisms. As the level of p53 is regulated by MDM2, which targets p53 for degradation, the G-allele of a polymorphism in intron 1 of MDM2 (rs2279744:G/T), that results in higher MDM2 levels, should be associated with a reduced p53 response and hence more DNA damage and corresponding tissue destruction. Similarly, the alleles of rs1042522 in TP53 that encode arginine (G-allele) or proline (C-allele) at codon 72, which cause increased pro-apoptotic (G-allele) or cell-cycle arrest activities (C-allele), respectively, may moderate p53's ability to prevent DNA damage. To test these hypotheses, we examined lung function in relation to cumulative history of smoking in a population-based cohort. The G-alleles in MDM2 and TP53 were found to be associated with accelerated smoking-related decline in lung function. These data support the hypothesis that p53 protects from DNA damage in humans and provides a potential explanation for the variation in lung function impairment amongst smokers.
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Mandhane, P. J. , Sears, M.R., Poulton, R., Greene, J. M. , Lou, W.Y., Taylor, D. R. , Hancox, R. J. | 2009
Cats and dogs and the risk of atopy in childhood and adulthood

Journal of Allergy and Clinical Immunology, 2009, 124(124), 745-750.e4.
www.ncbi.nlm.nih.gov/pubmed/19703709
Our ref: RO591

Show abstract » BACKGROUND: Exposure to cats and dogs during childhood has been linked to a lower risk of developing allergies. It remains unclear whether this is due to selective avoidance of pets by families with a history of allergies. The effects of pet ownership in adulthood are unknown. OBJECTIVES: We sought to assess the association between cat and dog ownership in childhood and early adulthood and the development of atopy in a population-based birth cohort of 1037 subjects. METHODS: Ownership of cats or dogs between birth and age 9 years and between the ages of 18 and 32 years was reported. Skin prick tests to common allergens were performed at 13 and 32 years. RESULTS: There was no evidence that families with a history of atopy avoided owning pets. There were significant cat-by-dog interactions for the development of atopy in both childhood and adulthood. Children who had owned both a cat and a dog were less likely to be atopic at age 13 years. Living with only one of these animals was not protective against atopy. Among those who were not atopic by age 13 years, having both a cat and a dog in adulthood was associated with a lower risk of new atopy by age 32 years. This association was only significant among those with a parental history of atopy. These effects were independent of a range of potential confounding factors. CONCLUSIONS: There is a synergistic interaction between cat and dog exposure that is associated with a lower risk of developing atopy in childhood and young adulthood.
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Polanczyk, G., Caspi, A., Williams, B.S., Price, T.S., Danese, A. , Sugden, K., Uher, R., Poulton, R., Moffitt, T. E. | 2009
Protective effect of CHHR1 gene variants on the development of adult depression following childhood maltreatment: Replication and extension

Archives of General Psychiatry, 2009, 66(66), 978-985.
http://archpsyc.ama-assn.org/cgi/content/abstract/66/9/978
Our ref: RO590

Show abstract » Context A previous study reported a genexenvironment interaction in which a haplotype in the corticotropin-releasing hormone receptor 1 gene (CRHR1) was associated with protection against adult depressive symptoms in individuals who were maltreated as children (as assessed by the Childhood Trauma Questionnaire [CTQ]). Objective To replicate the interaction between childhood maltreatment and a TAT haplotype formed by rs7209436, rs110402, and rs242924 in CRHR1, predicting adult depression. Design Two prospective longitudinal cohort studies. Setting England and New Zealand. Participants Participants in the first sample were women in the E-Risk Study (N=1116), followed up to age 40 years with 96% retention. Participants in the second sample were men and women in the Dunedin Study (N=1037), followed up to age 32 years with 96% retention. Main Outcome Measure Research diagnoses of past-year and recurrent major depressive disorder. Results In the E-Risk Study, the TAT haplotype was associated with a significant protective effect. In this effect, women who reported childhood maltreatment on the CTQ were protected against depression. In the Dunedin Study, which used a different type of measure of maltreatment, this finding was not replicated. Conclusions A haplotype in CRHR1 has been suggested to exert a protective effect against adult depression among research participants who reported maltreatment on the CTQ, a measure that elicits emotional memories. This suggests the hypothesis that CRHR1's protective effect may relate to its function in the consolidation of memories of emotionally arousing experiences.
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Grisham, J. R. , Anderson, T. M. , Poulton, R. , Moffitt, T. E. , Andrews, G. | 2009
Childhood neuropsychological deficits associated with adult obsessive-compulsive disorder

British Journal of Psychiatry, 2009, 195(195), 138-141.
www.ncbi.nlm.nih.gov/pubmed/19648544/1472-1465 (Electronic)
Our ref: RO587

Show abstract » BACKGROUND: Existing neuropsychological studies of obsessive-compulsive disorder (OCD) are cross-sectional and do not provide evidence of whether deficits are trait-related (antecedent and independent of symptomatology) or state-related (a consequence, dependent on symptomatology). AIMS: To investigate whether there are premorbid neuropsychological deficits associated with adult OCD. METHOD: Longitudinal data were collected from participants of the Dunedin Multidisciplinary Health and Developmental study. Neuropsychological data collected at age 13 were linked with age 32 diagnosis of OCD. RESULTS: The group who had OCD at age 32 differed significantly from the control group with no OCD on their performance at age 13 on neuropsychological tests of visuospatial, visuoconstructive and visuomotor skills, controlling for gender and socioeconomic status, but did not differ on tests of general IQ or verbal ability. Performance of the group with OCD on tests of executive functioning was mixed. CONCLUSIONS: Individuals with OCD have premorbid impairment in visuospatial abilities and some forms of executive functioning, consistent with biological models of OCD.
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Sutherland, T.J.T., Taylor, D.R. , Sears, M.R., McLachlan, C. R. , Greene, J.M., Poulton, R., Hancox, R. J. | 2009
Leptin, adiponectin and asthma: findings from a population-based cohort study

Annals of Allergy, Asthma & Immunology, 2009, 103(103), 101-107.
Our ref: RO586

Show abstract » Background: Obesity is thought to increase the risk of asthma, especially in women. It has been proposed that this association could be due to the immune-modulating effect of adipokines secreted by adipose tissue. Objective: To investigate whether aspects of the asthma phenotype are associated with higher levels of the proinflammatory adipokine leptin and lower levels of the anti-inflammatory adipokine adiponectin in a cross-sectional analysis of a group of young adults. Methods: Associations between leptin and adiponectin and a diagnosis of asthma, symptoms of wheeze, bronchodilator response, airflow obstruction, and exhaled nitric oxide were evaluated by logistic or linear regression in a population-based birth cohort of approximately 1,000 men and women aged 32 years. Further analyses adjusted for smoking and body fat. Results: There were no significant associations between leptin and any of the markers of the asthma phenotype in either men or women. In men, higher levels of adiponectin were associated with lower levels of exhaled nitric oxide but an increased risk of bronchodilator responsiveness. The inverse association with exhaled nitric oxide remained significant after adjustment for body fat, but the association with bronchodilator responsiveness did not. Adiponectin levels were not associated with any markers of asthma in women. Conclusions: The inverse association between adiponectin and exhaled nitric oxide in men warrants further investigation. However, the findings indicate that levels of leptin and adiponectin are unlikely to mediate the previously observed association between obesity and asthma.
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Milne, B. J. , Caspi, A. , Harrington, H. L., Poulton, R. , Rutter, M. , Moffitt, T. E. | 2009
Predictive value of family history on severity of illness: the case for depression, anxiety, alcohol dependence, and drug dependence

Archives of General Psychiatry, 2009, 66(66), 738-47.
www.ncbi.nlm.nih.gov/pubmed/19581565
Our ref: RO585

Show abstract » CONTEXT: If family history is associated with clinical features that are thought to index seriousness of disorder, this could inform clinicians predicting patients' prognosis and researchers selecting cases for genetic studies. Although tests of associations between family history and clinical features are numerous for depression, such tests are relatively lacking for other disorders. OBJECTIVE: To test the hypothesis that family history is associated with 4 clinical indexes of disorder (recurrence, impairment, service use, and age at onset) in relation to 4 psychiatric disorders (major depressive episode, anxiety disorder, alcohol dependence, and drug dependence). DESIGN: Prospective longitudinal cohort study. SETTING: New Zealand. PARTICIPANTS: A total of 981 members of the 1972 to 1973 Dunedin Study birth cohort (96% retention). MAIN OUTCOME MEASURES: For each disorder, family history scores were calculated as the proportion of affected family members from data on 3 generations of the participants' families. Data collected prospectively at the study's repeated assessments (ages 11-32 years) were used to assess recurrence, impairment, and age at onset; data collected by means of a life history calendar at age 32 years were used to assess service use. RESULTS: Family history was associated with the presence of all 4 disorder types. In addition, family history was associated with a more recurrent course for all 4 disorders (but not significantly for women with depression), worse impairment, and greater service use. Family history was not associated with younger age at onset for any disorder. CONCLUSIONS: Associations between family history of a disorder and clinical features of that disorder in probands showed consistent direction of effects across depression, anxiety disorder, alcohol dependence, and drug dependence. For these disorder types, family history is useful for determining patients' clinical prognosis and for selecting cases for genetic studies.
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