The Dunedin Study - DMHDRU

Publications

All peer reviewed publications are listed below.

Displaying page 9 of 22.

Associations of birth weight and length, childhood size and smoking to bone fractures during growth: evidence from a birth cohort study | 2004
Jones, I.E., Williams, S.M., Goulding, ... Show all » A. « Hide
American Journal of Epidemiology, 2004, 159(159), 343-350.
doi:10.1093/aje/kwh052
Our ref: RO455
Show abstract » Little information exists on risk factors associated with bone fractures during childhood and adolescence. This 1972/19731990/1991 New Zealand study examined the influence of birth size, height and weight throughout growth, smoking, breastfeeding, and sports participation on the risk of fracture in participants of the Dunedin Multidisciplinary Health and Development Study. Information on height, weight, fracture status, and lifestyle was collected at birth and at ages 3, 5, 7, 9, 11, 13, 15, and 18 years from parents and/or participants. Study members sustained 229 (girls) and 393 (boys) fractures between birth and age 18 years. Fracture risk was elevated (per standard deviation unit increase) in relation to birth length (prepubertal fractures only) (risk ratio (RR) = 1.28, 95% confidence interval (CI): 1.04, 1.58), weight at age 3 years (RR = 1.14, 95% CI: 1.03, 1.27), weight from ages 5 to 18 years (RR = 1.15, 95% CI: 1.03, 1.28), height at age 3 years (RR = 1.13, 95% CI: 1.01, 1.26), and height from ages 5 to 18 years (RR = 1.13, 95% CI: 1.02, 1.24). Birth weight, maternal smoking, breastfeeding, and sports participation had no significant effect on fracture risk. However, for teenagers, personal daily smoking increased the risk of fracture (RR = 1.43, 95% CI: 1.05, 1.95). The authors concluded that tall and heavy children had an increased risk of fracture, as did adolescents who smoked regularly.
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Childhood origins of violent behaviour in adults with schizophreniform disorder | 2003
Arseneault, L., Cannon, M., Murray, ... Show all » R. M., Poulton, R., Caspi, A., Moffitt, T.E. « Hide
British Journal of Psychiatry, 2003, 183(183), 520-525.
download pdf Our ref: RO454
Show abstract » Background: People with psychosis have an elevated risk of violence. Aims: To examine whether violent behaviour in adults with psychosis can be accounted for by psychotic symptoms or physical aggression in childhood. Method: We used data from a prospective longitudinal study of a complete birth cohort born in New Zealand. When cohort members were 26 years old, information was obtained on past-year psychiatric diagnosis of schizophreniform disorder and on violent behaviour. Childhood psychotic symptoms were measured at age 11 years using a diagnostic interview, and childhood physical aggression was assessed by teachers when cohort members were aged 7, 9 and 11 years. Results: Participants with schizophreniform disorder were more likely to be violent than participants without, even after controlling for sociodemographic variables and concurrent substance dependence disorders. Childhood psychotic symptoms were a strong risk factor for violence in adults with schizophreniform disorder, as was childhood physical aggression, although to a lesser extent. Conclusions: Violence by individuals with schizophreniform disorder could be prevented by monitoring early signs of psychotic symptoms and by controlling childhood physical aggression.
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Intergenerational relationships in young adulthood and their life-course, mental health and personality correlates | 2003
Belsky, J., Jaffee, S.R., Caspi, ... Show all » A., Moffitt, T.E., Silva, P.A. « Hide
Journal of Family Psychology, 2003, 17(17), 460-471.
download pdf Our ref: RO453
Show abstract » To evaluate effects of life-course events and experiences of young adults, as well as personality and mental-health history on intergenerational relationships in young adulthood, the authors examined dyadic relationship data drawn from a sample of more than 900 New Zealand 26-year-olds and their mothers and fathers. Results indicated that intergenerational relations were more positive when young adults were childless, not unemployed, married, and living away from home, but these factors did not interact with family relationship history in predicting relationship outcomes. Intergenerational relationships were less positive when children scored low on positive emotionality and constraint and high on negative emotionality and mental disorders, though these attributes did not account for the effect of life-course factors. Results are discussed in terms of the openness of the parent-child relationship in adulthood to further development.
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Core group evolution over time: high-risk sexual behaviour in a birth cohort between sexual debut and age 26 | 2003
Humblet, O., Paul, C., Dickson, ... Show all » N. « Hide
Sexually Transmitted Diseases, 2003, 30(30), 818-824.
Our ref: RO452
Show abstract » BACKGROUND AND OBJECTIVE: Among the limitations of the concept of a sexually transmitted disease core is uncertainty about the stability of sexual behavior over time. The objective was to shed light on characteristics and stability of the core group by assessing sexual behavior longitudinally in a birth cohort. GOALS: The goals were to describe group size and characteristics of people who report 5 or more heterosexual partners per year (a surrogate for the core group) at ages 18, 21, and 26 years. STUDY DESIGN: We used a prospective cohort study with a computer-presented questionnaire on sexual behavior. RESULTS: Of the original cohort members, 991 (97.3% of those believed to be alive) responded at at least one age. A total of 14.7% of women and 26.0% of men were in the core group at either age 18 or 21 or 26, but only 0.5% and 0.9% of women and men, respectively, were in the core group at all ages. Those in the core group were significantly more likely to report concurrent partnerships and higher sexually transmitted disease (STD) rates. Early age at first sex was consistently associated with being in the core group, whereas those with less education were more likely to be in the core group at age 18 but not at later ages. CONCLUSION: The high degree of variability in sexual behavior over time of individuals adds another degree of complexity to the identification of a core group for STD transmission.
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A population-based study of help-seeking for self-harm in young adults | 2003
Nada-Raja, S., Morrison, D.N., Skegg, ... Show all » K.M. « Hide
Australian and New Zealand Journal of Psychiatry, 2003, 37(37), 600-605.
Our ref: RO451
Show abstract » Objective: To examine help-seeking for self-harm in a population-based sample of young adults. Method: Nine hundred and sixty-five participants aged 26 years were interviewed about help-seeking and barriers to help-seeking for a range of self-harmful behaviours. Self-harm included the traditional methods of suicide ( ICD-9 self-harm) and other self-harmful behaviours such as self-battery and self-biting. Results: Just over half of the 25 in the ICD-self-harm group ( based on ICD-9 self-harm criteria) and one-fifth of the 119 in the other self-harmful behaviour group had sought professional help. Counsellors, psychologists, and general practitioners were the commonest sources of help. Most participants rated help received from health services favourably, however, emergency services were rated less favourably than other health services. Among 77 self-harm participants who did not seek help, just over one-third reported attitudinal barriers. Conclusions: To encourage help-seeking by young adults who self-harm, especially young men who are at high risk for self-harm and suicide, it may be necessary to identify ways to reduce attitudinal barriers.
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Commentary: Personality and the socioeconomic-health gradient | 2003
Poulton, R., Caspi, A.
International Journal of Epidemiology, 2003, 32(32), 975-977.
Our ref: RO450
Show abstract » The socioeconomic (SES) gradient in health whereby higher position equates to better health spans both time and place and is found for almost all diseases and many health risk behaviours. The near universality of this phenomenon has led to a search for more fundamental causes. Although differences in material resources and/or psychosocial attributes have been postulated, neither can satisfactorily explain the ubiquity of the socioeconomic-health gradient. In this edition of the journal, Pulkki and colleagues ask if adolescent personality traits can explain the inverse relation between selected cardiovascular health risk behaviours and educational achievement. Their longitudinal study shows that a set of Type A - like personality traits predict educational attainment (a component of SES) and accounts for part of the SES gradient in health risk behaviour. The study delivers an important message that we hope will not be lost in the details of the work. The message, as we understand it, is that collaboration between epidemiologists and personality psychologists may prove helpful in better understanding how ones position in the social structure affects health. In this commentary, we amplify two issues. First, we discuss promising directions in the measurement of personality, and the need to use more comprehensive, and more comparable, personality measurement across epidemiological studies. Second, we discuss issues of causation, and identify alternative ways in which personality may contribute to the social gradient in health.
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Developmental trajectories of childhood disruptive behavior disorders and adolescent delinquency: A cross-national replication | 2003
Broidy, L.M., Nagin, D.S., Tremblay, ... Show all » R.E., Brame, R., Dodge, K., Fergusson, D.M., Horwood, L.J., Loeber, R., Laird, R., Lynam, D.R., Moffitt, T.E. « Hide
Developmental Psychology, 2003, 39(39), 222-245.
download pdf Our ref: RO449
Show abstract » This study used data from 6 sites and 3 countries to examine the developmental course of physical aggression in childhood and to analyze its linkage to violent and nonviolent offending outcomes in adolescence. The results indicate that among boys there is continuity in problem behavior from childhood to adolescence and that such continuity is especially acute when early problem behavior takes the form of physical aggression. Chronic physical aggression during the elementary school years specifically increases the risk for continued physical violence as well as other nonviolent forms of delinquency during adolescence. However, this conclusion is reserved primarily for boys, because the results indicate no clear linkage between childhood physical aggression and adolescent offending among female samples despite notable similarities across male and female samples in the developmental course of physical aggression in childhood.
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A longitudinal population-based cohort study of childhood asthma followed to adulthood | 2003
Sears, M.R., Greene, J.M., Willan, ... Show all » A., Wiecek, E., Taylor, D.R., Flannery, E.M., Cowan, J.O., Herbison, G. P. , Silva, P.A., Poulton, R. « Hide
New England Journal of Medicine, 2003, 349(349), 1414-1422.
Our ref: RO448
Show abstract » Background The outcome of childhood asthma in adults has been described in high-risk cohorts, but few population-based studies have reported the risk factors for persistence and relapse. Methods We assessed children born from April 1972 through March 1973 in Dunedin, New Zealand, repeatedly from 9 to 26 years of age with questionnaires, pulmonary-function tests, bronchial-challenge testing, and allergy testing. Results By the age of 26 years, 51.4 percent of 613 study members with complete respiratory data had reported wheezing at more than one assessment. Eighty-nine study members (14.5 percent) had wheezing that persisted from childhood to 26 years of age, whereas 168 (27.4 percent) had remission, but 76 (12.4 percent) subsequently relapsed by the age of 26. Sensitization to house dust mites predicted the persistence of wheezing (odds ratio, 2.41; P=0.001) and relapse (odds ratio, 2.18; P=0.01), as did airway hyperresponsiveness (odds ratio for persistence, 3.00; P<0.001; odds ratio for relapse, 3.03; P<0.001). Female sex predicted the persistence of wheezing (odds ratio, 1.71; P=0.03), as did smoking at the age of 21 years (odds ratio, 1.84; P=0.01). The earlier the age at onset, the greater the risk of relapse (odds ratio, 0.89 per year of increase in the age at onset; P<0.001). Pulmonary function was consistently lower in those with persistent wheezing than in those without persistent wheezing. Conclusions In an unselected birth cohort, more than one in four children had wheezing that persisted from childhood to adulthood or that relapsed after remission. The factors predicting persistence or relapse were sensitization to house dust mites, airway hyperresponsiveness, female sex, smoking, and early age at onset. These findings, together with persistently low lung function, suggest that outcomes in adult asthma may be determined primarily in early childhood.
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Breastfeeding and asthma: Appraising the controversy - a rebuttal. Commentary | 2003
Sears, M.R., Taylor, D.R., Poulton, ... Show all » R. « Hide
Pediatric Pulmonology, 2003, 36(36), 366-368.
Our ref: RO447
Show abstract » No abstract
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A longitudinal evaluation of adolescent depression and adult obesity | 2003
Richardson, L., Davis, R., Poulton, ... Show all » R., McCauley, E., Moffitt, T.E., Caspi, A., Connell, F.A. « Hide
Archives of Pediatrics & Adolescent Medicine, 2003, 157(157), 739-745.
Our ref: RO446
Show abstract » Background: Prior studies have had conflicting results regarding the relationship between adolescent depression and adult obesity. Objective: To test the hypothesis that depression in adolescence would increase the risk for obesity in early adulthood. Methods: We used data from a longitudinal study of a birth cohort of children born between April 1, 1972, and March 31, 1973, in Dunedin, New Zealand (N = 1037). These data included regular diagnostic mental health interviews and height/weight measurements throughout childhood and adolescence. We performed logistic regression analyses to assess the relationship between major depression in early or late adolescence and the risk for obesity at 26 years of age. Results: Major depression occurred in 7% of the cohort during early adolescence (11, 13, and 15 years of age) and 27% during late adolescence (18 and 21 years of age). At 26 years of age, 12% of study members were obese. After adjusting for each individual's baseline body mass index (calculated as the weight in kilograms divided by the square of height in meters), depressed late adolescent girls were at a greater than 2-fold increased risk for obesity in adulthood compared with their non-depressed female peers (relative risk, 2.32; 95% confidence interval, 1.29-3.83). A dose-response relationship between the number of episodes of depression during adolescence and risk for adult obesity was also observed in female subjects. The association was not observed for late adolescent boys or for early adolescent boys or girls. Conclusions: Depression in late adolescence is associated with later obesity, but only among girls. Future studies should address reasons for these age and sex differences and the potential for intervention to reduce the risk for adult obesity in depressed older adolescent girls.
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Prior juvenile diagnoses in adults with mental disorder: Developmental follow-back of a prospective-longitudinal cohort | 2003
Kim-Cohen, J., Caspi, A., Moffitt, ... Show all » T.E., Harrington, H. L. , Milne, B.J., Poulton, R. « Hide
Archives of General Psychiatry, 2003, 60(60), 709-719.
download pdf Our ref: RO445
Show abstract » Background: If most adults with mental disorders are found to have a juvenile psychiatric history, this would shift etiologic research and prevention policy to focus more on childhood mental disorders. Method: Our prospective longitudinal study followed up a representative birth cohort (N = 1037). We made psychiatric diagnoses according to DSM criteria at 11, 13, 15, 18, 21, and 26 years of age. Adult disorders were defined in the following 3 ways: (1) cases diagnosed using a standardized diagnostic interview, (2) the subset using treatment, and (3) the subset receiving intensive mental health services. Follow-back analyses ascertained the proportion of adult cases who had juvenile diagnoses and the types of juvenile diagnoses they had. Results: Among adult cases defined via the Diagnostic Interview Schedule, 73.9% had received a diagnosis before 18 years of age and 50.0% before 15 years of age. Among treatment-using cases, 76.5% received a diagnosis before 18 years of age and 57.5% before 15 years of age. Among cases receiving intensive mental health services, 77.9% received a diagnosis before 18 years of age and 60.3% before 15 years of age. Adult disorders were generally preceded by their juvenile counterparts (eg, adult anxiety was preceded by juvenile anxiety), but also by different disorders. Specifically, adult anxiety and schizophreniform disorders were preceded by a broad array of juvenile disorders. For all adult disorders, 25% to 60% of cases had a history of conduct and/or oppositional defiant disorder. Conclusions: Most adult disorders should be reframed as extensions of juvenile disorders. In particular, juvenile conduct disorder is a priority prevention target for reducing psychiatric disorder in the adult population.
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Relationship between abdominal pain subgroups in the community and psychiatric diagnosis and personality: a birth cohort study | 2003
Howell, S., Poulton, R., Caspi, ... Show all » A., Talley, N. J. « Hide
Journal of Psychosomatic Research, 2003, 55(55), 179-187.
Link to full publication »
Our ref: RO444
Show abstract » Introduction: It is unclear if there is a causal link between psychiatric disorders and unexplained chronic gastrointestinal (GI) symptomatology. The role of personality is also in dispute. We aimed to assess the association of these factors with functional GI symptoms in a birth cohort study. Methods: The Dunedin birth cohort is well characterised and has been followed-up prospectively to age 26 (n=980). Measured were upper and lower GI symptoms over the prior year at age 26 using a validated questionnaire, psychiatric diagnoses at ages 18 and 21 by standardised interview applying DSM-III-R criteria, and personality at age 18 using the Multidimensional Personality Questionnaire (MPQ). Natural symptom groupings were identified using factor analysis and k-means clustering. The association of these clusters and psychiatric diagnoses or personality was assessed by logistic regression. Results: The k-means analysis produced a six-cluster solution, which was made up of a health group, and five disease clusters defined by higher than average scores on a single symptom. A diagnosis of depression at age 18 or 21 years was associated with increases in the odds of 1.69 (95% CI: 1.27'2.25) for all GI, of 2.16 (95% CI: 1.12'4.16) for dysmotility and of 2.07 (95% CI: 1.13'3.80) for constipation, but not with the other clusters. Similar results were observed with respect to anxiety disorders for the odds of GI overall (OR=1.42, 95% CI: 1.01'1.99) and constipation (OR=2.11, 95% CI: 1.17'3.79). The personality subscales were not strongly linked; membership of any diseased cluster was associated with a reduced odds of being in the fourth quartile for the well-being scale (OR=0.64, 95% CI: 0.46'0.88) but increased odds of being in the fourth quartile for the social potency scale (OR=1.64, 95% CI: 1.18'2.28). Conclusions: In a young adult community sample, unexplained GI symptoms appear to be linked to psychiatric disorders but personality differences were minimal.
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Occupational level of the father and alcohol consumption during adolescence: patterns and predictors | 2003
Droomers, M., Shrijvers, C.T.M., Casswell, ... Show all » S., Mackenback, J.P. « Hide
Journal of Epidemiology and Community Health, 2003, 57(57), 704-710.
Our ref: RO443
Show abstract » Study objective: This paper describes and attempts to explain the association between occupational level of the father and high alcohol consumption among a cohort of New Zealand adolescents from age 11 to 21. Design: Data were obtained from the longitudinal Dunedin multidisciplinary health and development study. At each measurement wave, those who then belonged to the quartile that reported the highest usual amount of alcohol consumed on a typical drinking occasion were categorised as high alcohol consumers. Potential predictors of high alcohol consumption included environmental factors, individual factors, and educational achievement measured at age 9, 11, or 13. Longitudinal logistic GEE analyses described and explained the relation between father's occupation and adolescent alcohol consumption. Setting: Dunedin, New Zealand. Participants: About 1000 children were followed up from birth in 1972 until adulthood. Main results: A significant association between fathers' occupation and adolescent alcohol consumption emerged at age 15. Overall adolescents from the lowest occupational group had almost twice the odds of being a large consumer than the highest occupational group. The association between father's occupation and high alcohol consumption during adolescence was explained by the higher prevalence of familial alcohol problems and friends approving of alcohol consumption, lower intelligence scores, and lower parental attachment among adolescents from lower occupational groups. Conclusions: Socioeconomic background affects adolescent alcohol consumption substantially. This probably contributes to cumulation of disadvantage. Prevention programmes should focus on adolescents from lower socioeconomic groups and make healthier choices the easier choices by means of environmental change.
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Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene | 2003
Caspi, A., Sugden, K., Moffitt, ... Show all » T.E., Taylor, A., Craig, I., Harrington, H. L., McClay, J., Mill, J.S, Martin, J. , Braithwaite, A., Poulton, R. « Hide
Science, 2003, 301(301), 386-389.
Our ref: RO440
Show abstract » In a prospective-longitudinal study of a representative birth cohort, we tested why stressful experiences lead to depression in some people but not in others. A functional polymorphism in the promoter region of the serotonin transporter (5-HTT) gene was found to moderate the influence of stressful life events on depression. Individuals with one or two copies of the short allele of the 5-HTT promoter potymorphism exhibited more depressive symptoms, diagnosable depression, and suicidality in relation to stressful life events than individuals homozygous for the long allele. This epidemiological study thus provides evidence of a gene-by-environment interaction, in which an individual's response to environmental insults is moderated by his or her genetic makeup.
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Children's behavioral styles at age 3 are linked to their adult personality traits at age 26 | 2003
Caspi, A., Harrington, H. L., Milne, ... Show all » B.J., Amell, J.W., Theodore, R.F., Moffitt, T.E. « Hide
Journal of Personality , 2003, 71(71), 495-513.
Our ref: RO439
Show abstract » We observed 1,000 3-year-old children who exhibited five temperament types: Undercontrolled, Inhibited, Confident, Reserved, and Well-adjusted. Twenty-three years later, we reexamined 96% of the children as adults, using multiple methods of comprehensive personality assessment, including both self- and informant-reports. These longitudinal data provide the longest and strongest evidence to date that children's early-emerging behavioral styles can foretell their characteristic behaviors, thoughts, and feelings as adults, pointing to the foundations of the human personality in the early years of life.
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Socioeconomic status and drinking patterns in young adults | 2003
Casswell, S., Pledger, M., Hooper, ... Show all » R. « Hide
Addiction, 2003, 98(98), 601-610.
Our ref: RO438
Show abstract » Aims: To investigate the relationship between several indicators of socio-economic status and drinking patterns in young adulthood. Design: Data collected in a longitudinal study of young adults was analysed using repeated measures models to examine the relationship between income, occupational activity and educational achievement and patterns of drinking. Setting: These data were collected as part of a longitudinal study of a birth cohort of New Zealanders. They were interviewed for the most part in a central location using face to face method and a computer assisted alcohol interview. Participants: The participants were members of the Dunedin Multidisciplinary Health and Development Study aged 18, 21 and 26. Nine hundred and sixty nine study members contributed to the analysis. Study members have been found to be broadly representative of the New Zealand population and cross national studies suggest findings are generalisable to other similar market economies. Measurements: Three indicators of socio-economic status were used; educational achievement, occupational activity and income. The educational achievement indicator at age 18 had three levels that ranged from no school qualifications to higher school qualifications. For age 21 two additional categories of tertiary educational achievement were included to make five categories and for age 26 higher tertiary degrees were included in the measure to make six categories. Five categories of occupational activity were used: unemployed; student; employed in higher status occupation; employed in lower status occupation; and homemakers/unpaid workers. Income data was also used. Two measures of alcohol consumption were used. These were the frequency of drinking and the typical quantity of alcohol consumed per drinking occasion in the past year. Both of these measures were computed from a series of five location-specific questions. Findings: Frequency of drinking increased over these early adult years and the quantities consumed peaked at age 21 and decreased thereafter for both males and females. Frequency of drinking during these years was influenced by income with the higher income respondents drinking more often and this was persistent overtime. Quantity of drinking was most influenced by educational achievement. The less well educated young adult drank significantly more during a drinking occasion and at all ages (18, 21 and 26). There was also a relationship between educational achievement and frequency of drinking for males at age 18 and a relationship between womens occupational activity and the quantities they consumed. Conclusions: The quantities of alcohol consumed and the frequency of drinking had different relationships with measures of socio-economic status. Those with fewer educational qualifications had heavier drinking occasions. More frequent drinking was more common among those with higher income but income had no relationship with the quantities consumed. The finding that the dimensions of drinking operate differently explains the lack of consistency in previous research which has investigated socio-economic status and the volumes of alcohol consumed. The findings of higher quantities consumed among those of lower social status may explain some of the reduced life expectancy found among those with lower socio-economic status.
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Gender bias in IQ-discrepancy and post-discrepancy definitions of reading disability | 2003
Share, D.L., Silva, P.A.
Journal of Learning Disabilities, 2003, 36(36), 4-14.
Our ref: RO437
Show abstract » The present study investigated the hypothesis that the higher prevalence of reading disability (RD) often observed among boys is partly an artifact of gender bias in the prediction of reading from IQ. The relevant regression statistics derived from a sample of more than 900 children revealed a statistically significant intercept bias. Predicted reading scores for boys were systematically overestimated, thereby inflating IQ-reading discrepancies; the converse was found for girls. When defined separately for girls and boys, severe underachievement in reading was found to be equally prevalent in both genders and, furthermore, was associated with qualitatively and quantitatively similar patterns of deficits. Because the bias arose from general differences between boys and girls in reading score distributions (a lower mean and greater variance for boys) rather than from differences in IQ scores, gender bias poses a potential threat not only to traditional IQ-discrepancy definitions but also to post-discrepancy definitions that are based solely on reading score cutoffs.
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Identifying factors that predict persistent driving after drinking, unsafe driving after drinking, and driving after using cannabis among young adults | 2003
Begg, D.J., Langley, J.D., Stephenson, ... Show all » S. « Hide
Accident Analysis and Prevention, 2003, 35(35), 669-675.
download pdf Our ref: RO436
Show abstract » The main aim of this study was to identify adolescent/young adulthood factors that predicted persistent driving after drinking, persistent unsafe driving after drinking, and persistent cannabis use and driving among young adults. It was a longitudinal study of a birth cohort (n=933, 474 males and 459 females) and was based on data collected at ages 15, 18, 21 and 26 years. At each of these ages members of the cohort attended the research unit for a personal interview by a trained interviewer, using a standardised questionnaire. For this study, the data for the outcome measures (persistent driving after drinking, persistent unsafe driving after drinking, and persistent driving after using cannabis) were obtained at ages 21 and 26 years. The main explanatory measures were collected at ages 15, 18, 21 years and included demographic factors (academic qualifications, employment, parenting); personality measures; mental health measures (substance use, cannabis dependence, alcohol dependence, depression); anti-social behaviour (juvenile arrest, aggressive behaviour, court convictions); early driving behaviour and experiences (car and motorcycle licences, traffic crashes). The analyses were conducted by gender. The results showed that females who persisted in driving after drinking (13%, n=61) were more likely than the others to have a motorcycle licence at 18. The males who persisted in driving after drinking (28%, n=135) were more likely than the other males to have some school academic qualifications and to be employed at age 26. Compared to the other males, those who persisted in unsafe driving after drinking (4%, n=17) were more likely to be aggressive at 18 and alcohol dependent at 21. Only six (1%) females persisted in unsafe driving after drinking so regression analyses were not conducted for this group. For persistent driving after using cannabis, the univariate analyses showed that females who persisted with this behaviour tended to have high substance use at 18, cannabis dependence at 21, police contact as a juvenile, and to be a parent at 21. For this group, because of the small numbers (3%, n=13) multivariate analyses were not appropriate. For the males who persisted in driving after using cannabis (14%, n=68) a wide range of variables were significant at the univariate stage. The multivariate analysis showed that the most important factors were dependence on cannabis at 21, at least one traffic conviction before 21, a non traffic conviction before 18, and low constraint at 18. Conclusion: These results show different characteristics were associated with persistence in each of these outcome behaviours. This indicates that different approaches would be required if intervention programmes were to be developed to target these behaviours.
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Work experiences and personality development in young adulthood | 2003
Roberts, B.W., Caspi, A., Moffitt, ... Show all » T.E. « Hide
Journal of Personality and Social Psychology, 2003, 84(84), 582-593.
download pdf Our ref: RO435
Show abstract » This longitudinal study provides an analysis of the relationship between personality traits and work experiences with a special focus on the relationship between changes in personality and work experiences in young adulthood. Longitudinal analyses uncovered 3 findings. First, measures of personality taken at age 18 predicted both objective and subjective work experiences at age 26. Second, work experiences were related to changes in personality traits from age 18 to 26. Third, the predictive and change relations between personality traits and work experiences were corresponsive: Traits that selected people into specific work experiences were the same traits that changed in response to those same work experiences. The relevance of the findings to theories of personality development is discussed.
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Same-sex attraction in a birth cohort: prevalence and persistence in early adulthood | 2003
Dickson, N., Paul, C., Herbison, ... Show all » G.P. « Hide
Social Science and Medicine, 2003, 56(56), 1607-1615.
Our ref: RO434
Show abstract » There is a continuing debate about the importance of social versus biological factors in the expression of same-sex attraction. Investigation of prevalence, continuities, and changes over time among young adults growing up in a country with a relatively accepting climate to homosexuality is likely to illuminate this debate. Analyses were therefore undertaken of self-reported same-sex attraction at age 21 and 26, in a cohort of about 1000 people born in 1972/3 in one New Zealand city. Participants were also asked about same-sex behaviour and attitudes to same-sex relationships. By age 26, 10.7% of men and 24.5% of women reported being attracted to their own sex at some time. This dropped to 5.6% of men and 16.4% of women who reported some current same-sex attraction. Current attraction predominantly to their own sex or equally to both sexes (major attraction) was reported by 1.6% of men and 2.1% of women. Occasional same-sex attraction, but not major attraction, was more common among the most educated. Between age 21 and 26, slightly more men moved away from an exclusive heterosexual attraction (1.9% of all men) than moved towards it (1.0%), while for women, many more moved away (9.5%) than towards (1.3%) exclusive heterosexual attraction. These findings show that much same-sex attraction is not exclusive and is unstable in early adulthood, especially among women. The proportion of women reporting some same-sex attraction in New Zealand is high compared both to men, and to women in the UK and US. These observations, along with the variation with education, are consistent with a large role for the social environment in the acknowledgement of same-sex attraction. The smaller group with major same-sex attraction, which changed less over time, and did not differ by education, is consistent with a basic biological dimension to sexual attraction. Overall these findings argue against any single explanation for homosexual attraction.
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Sexual orientation and self-harm in men and women | 2003
Skegg, K.M., Nada-Raja, S., Dickson, ... Show all » N., Paul, C., Williams, S.M. « Hide
American Journal of Psychiatry, 2003, 160(160), 541-546.
Our ref: RO433
Show abstract » OBJECTIVE: Recent studies of homosexual people have found higher rates of nonfatal suicidal behavior than among heterosexuals. The purpose of this study was to determine associations between self-harm and sexual orientation for men and women separately, defining sexual orientation by sexual attraction rather than by behavior. METHOD: In a birth cohort of 1,019 New Zealand young adults eligible to be interviewed at age 26 years, 946 participated in assessments of both sexual attraction and self-harm. RESULTS: Both women and men who had experienced same-sex attraction had higher risks of self-harm. The odds ratios for suicidal ideation in the past year were 3.1 for men and 2.9 for women. Odds ratios for ever having deliberately self-harmed were 5.5 for men and 1.9 for women. Men with same-sex attraction were also significantly more likely to report having attempted suicide. In both sexes, a greater degree of same-sex attraction predicted increasing likelihood of self-harm, with over one-third of men and women with persistent major same-sex attraction reporting this. Men with even a minor degree of same-sex attraction had high rates of self-harm and resulting physical injury. One-quarter of deliberate self-harm among men and one-sixth among women was potentially attributable to same-sex attraction. CONCLUSIONS: This study provides evidence of a link between increasing degrees of same-sex attraction and self-harm in both men and women, with the possibility of some difference between the sexes that needs to be explored further.
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Fluctuating asymmetry and physical health among young adults | 2003
Milne, B.J., Belsky, J., Poulton, ... Show all » R., Thomson, W.M., Caspi, A., Kieser, J. « Hide
Evolution and Human Behavior, 2003, 24(24), 53-63.
Our ref: RO432
Show abstract » Fluctuating asymmetry (FA), the random deviations from perfect symmetry found in the bilateral structures of bilaterally symmetric organisms, has been inconsistently linked to health. In this study, the association between FA and an array of health measures was determined for a large (n=965) general population sample of 26-year-old men and women. FA was significantly associated with two health measures: body mass index (BMI), but only for females (more ASYMMETRIC=greater BMI), and number of medical conditions (asymmetric subjects were more likely to report they had two or more medical conditions). FA was not associated with waist/hip ratio, systolic blood pressure (BP), blood cholesterol, cardiorespiratory fitness, and periodontal disease. Two suggestions are offered for these results. The first is that, as a consequence of the association between developmental stability and low metabolism [Evol. Hum. Behav. 18 (1997) 15.], stable and unstable groups will differ on some health measures (e.g., BMI), but not those related to body maintenance (e.g., BP). The second is that because of the minimization of environmental stressors in Westernized societies, there is too much homogeneity in asymmetry among the population to detect differences within samples.
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Effectiveness of a community-based truancy intervention: a pilot study | 2002
Milne, B.J., Chalmers, S., Waldie, ... Show all » K.E., Darling, H., Poulton, R. « Hide
New Zealand Journal of Educational Studies, 2002, 37(37), 191-203.
Our ref: NZ86
Show abstract » This study assessed the effectiveness of a community-based intervention programme aimed at reintegrating youths back into school and improving problem behaviours and family functioning. Sixty-six youths (35 male, age range: 11 16 years) referred primarily for truancy, received an individualised intervention (lasting 6-13 months) which, for 31 youths, included mentoring. Pre- and post-intervention assessments included frequency of truancy, the Youth Self Report (YSR) and the Family Environment Scales (FES) (n=59). Results indicated that (a) the proportion of youths truanting persistently decreased from 82% to 37%, (b) males (particularly non-persistent truants) showed improvement on the YSR delinquency subscale; females improved on YSR delinquency, depression and aggression subscales, and (c) youths FES conflict scores improved (particularly those who were assigned mentors). Drug use was related to improvements across all three domains, but in different ways (e.g., drug non-use was related to improvements in truancy while drug use was related to delinquency improvements). It is concluded that the intervention was partially successful. Its success may have been due to the multimodal and tailored nature of the program.
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Prevalence and correlates of irritable bowel symptoms in a New Zealand birth cohort | 2002
Barbezat, G.O., Poulton, R., Milne, ... Show all » B.J., Howell, S., Fawcett, J.P., Talley, N. J. « Hide
New Zealand Medical Journal, 2002, 115(115), U220.
http://www.nzma.org.nz/journal/115-1164/220/
Our ref: NZ85
Show abstract » Aim: To determine the prevalence and correlates of bowel symptoms and the irritable bowel syndrome (IBS) in a birth cohort of young New Zealanders. Methods: Participants in the Dunedin Multidisciplinary Health and Development Study at age 26 completed a validated Bowel Disease Questionnaire expressing their experience of clearly defined symptoms over the previous 12 months. Results: 980 participants (499 male, 481 female, comprising 96% of the birth cohort) completed the questionnaire. Sixty four per cent had at least one of the measured symptoms; abdominal pain was reported in 46.5%, chronic constipation in 9.1%, and chronic diarrhoea in 17.1%. A diagnosis of IBS could be made by using two or more of Mannings diagnostic criteria in 18.8%, three or more criteria in 10.3%, and more than three in 3.3%. Symptoms were more than twice as frequent and severe in females than males. Conclusions: Bowel-related abdominal symptoms, including those required for a diagnosis of IBS are very common in 26-year-old New Zealanders; the prevalence of these symptoms is very similar to that recorded previously in Europe and the USA.
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Unwanted pregnancies involving young women and men in a New Zealand birth cohort | 2002
Dickson, N., Wilson, M., Herbison, ... Show all » G.P., Paul, C. « Hide
New Zealand Medical Journal, 2002, 115(115), 155-158.
Our ref: NZ84
Show abstract » Aims. To examine the circumstances of wanted and unwanted pregnancies before age 25 years for both women and men, and compare the circumstances of the most undesired pregnancies with all others. Methods. Cross-sectional study within a birth cohort using a computer-presented questionnaire. Results. Of the 477 women, 173 (36%) had been pregnant before age 25 years, and experienced 289 pregnancies of which 173 (60%) were unwanted. Of the 489 men, 142 (29%) reported 225 pregnancies before age 25, of which 165 (73%) were unwanted. By age 25 about a quarter of the study members (27% of women and 24% of men), had been involved in at least one unwanted pregnancy. Wantedness increased with age and length of relationship with the other parent; both factors remained significant in multivariate analysis for men, but not age for women. For women unwanted pregnancies were more likely to be due to non-use of contraception than failure. For both women and men the commonest single reason for not using contraception was not thinking about it, followed by alcohol use. Conclusions. An environment has emerged for men and women in their twenties in New Zealand where most are sexually active but do not want a pregnancy to occur. To delay pregnancy for a prolonged period requires dedication and commitment to effective contraception. While more attention needs to be paid to promotion of effective use of contraception, more understanding is called for over the difficulties of avoiding pregnancy with long-term reversible contraception. A further approach to the problem of unwanted pregnancies which should be investigated is to encourage committed sexual relationships.
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It's not just who you're with, it's who you are: Personality and relationship experiences across multiple relationships | 2002
Robins, R.W., Caspi, A., Moffitt, ... Show all » T.E. « Hide
Journal of Personality, 2002, 70(70), 925-964.
Our ref: RO442
Show abstract » The present study examined the influence of stable personality traits on romantic relationships using longitudinal data on a large, representative sample of young adults. Relationship experiences (quality, conflict, and abuse) showed relatively small meanlevel changes over time and significant levels of rankorder stability, even across different relationship partners. Antecedent personality traits (assessed at age 18) predicted relationship experiences at age 26 and change in relationship experiences from age 21 to 26. Conversely, relationship experiences also predicted change in personality. Importantly, these findings generally held across relationship partners, suggesting that some people tend to be generally happy (or unhappy) across relationships, and this is due, in part, to stable individual differences in personality. Discussion focuses on the broader implications of the findings, in particular the need for relationship researchers to consider the importance of personality for why relationships thrive or fail and the need for personality researchers to consider the impact of relationship experiences on intraindividual personality development.
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The targets of violence committed by young offenders with alcohol dependence, marijuana dependence and schizophrenia-spectrum disorders: findings from a birth cohort | 2002
Arseneault, L., Moffitt, T.E., Caspi, ... Show all » A., Taylor, A. « Hide
Criminal Behavior and Mental Health, 2002, 12(12), 155-168.
download pdfLink to full publication »
Our ref: RO441
Show abstract » Background: Estimates of who is most at risk from violence by people with mental illness rest mainly on identified patient samples. This study, without such selection bias, examined the targets of violence committed by young adults with as-yet untreated alcohol dependence, marijuana dependence, or schizophrenia-spectrum disorders, to determine the extent to which their victims were co-residents or non-household members. Methods: In a total birth cohort of 21-year-olds (n = 956), past-year prevalence of alcohol dependence, marijuana dependence and schizophrenia-spectrum disorders were diagnosed using standardized DSM-III-R interviews. None of the people with schizophrenia-spectrum disorder has been hospitalized in the past year. Past-year violence and victim targets were measured using self-reports. Results: Compared with controls, cohort members with substance dependence or schizophrenia-spectrum disorders had higher prevalence and frequency rates of assault against co-residents, against non-household members, and also robbery and gang fights. Out of 39, five individuals with schizophrenia-spectrum disorder committed violent street crimes. Persons with substance dependence had similar proportions of violence against co-resident and non-household members, but persons with schizophrenia-spectrum disorders tended to victimize co-residents more than others. Conclusions: At the age when they are most likely to contribute to the community's violence burden, young untreated offenders with alcohol or marijuana dependence or with schizophrenia-spectrum disorders assault not only co-residents, but others as well, and commit violent street crimes. Families, schoolteachers and primary care physicians have an important potentially preventive role in early identification and treatment of the disorders.
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The long-term significance of teacher-rated hyperactivity and reading ability in childhood: findings from two longitudinal studies | 2002
McGee, R., Prior, M., Williams, ... Show all » S.M., Smart, D., Sanson, A. « Hide
Journal of Child Psychology and Psychiatry, 2002, 43(43), 1004-1017.
Our ref: RO431
Show abstract » Background: The aims of this study were twofold: first, to examine behavioural and academic outcomes of children with hyperactivity, using data from two longitudinal studies; and second, to examine comparable psychosocial outcomes for children with early reading difficulties. Methods: Measures of teacher-rated persistent hyperactivity, and reading ability obtained during early primary school were available for children from the Australian Temperament Project and the Dunedin Multidisciplinary Health and Development Study. Both samples were followed up to assess behavioural and academic outcomes during the adolescent and early adult years. Family background, antisocial behaviour and literacy were controlled in the first set of analyses to examine the influence of early hyperactivity. Results: There were strong linear relationships between early hyperactivity and later adverse outcomes. Adjustment for other childhood variables suggested that early hyperactivity was associated with continuing school difficulties, problems with attention and poor reading in adolescence. Early reading difficulties, after controlling for early hyperactivity, predicted continuing reading problems in high school and leaving school with no qualifications. Conclusions: The findings suggest that there are dual pathways from early inattentive behaviours to later inattention and reading problems, and from early reading difficulties to substantial impairments in later academic outcomes.
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Trajectories of drinking from 18 to 26: identification and prediction | 2002
Casswell, S., Pledger, M., Pratap, ... Show all » S. « Hide
Addiction, 2002, 97(97), 1427-1437.
www.ncbi.nlm.nih.gov/pubmed/12410783
Our ref: RO430
Show abstract » OBJECTIVE: To identify developmental trajectories of drinking between the ages of 18 and 26 years and to identify variables, amenable to policy influence, which predict these trajectories. DESIGN: Longitudinal data were analysed using latent class mixture modelling. SETTING: Participants were interviewed in a central location. PARTICIPANTS: Provincial city birth cohort, cross-national studies suggest findings are generalizable to other similar market economies. MEASUREMENTS: The frequency of drinking over the past year and the typical quantity consumed per drinking occasion were computed from five location-specific questions. Measures used to predict membership of trajectory groups were ease of access to alcohol, drinking on licensed premises, response to alcohol advertising, educational achievement, parental consumption, age of onset of regular drinking and living arrangements. RESULTS: Three trajectories of quantities consumed showed reduced consumption after age 21 but one trajectory showed marked increases. Three trajectories of frequency of drinking increased or remained stable over time. Access to licensed premises at age 18 had the most significant impact on membership of the trajectory groups and educational achievement had a significant impact on membership of the heavier quantity trajectory groups. Parental alcohol consumption, access to alcohol at 15 years, liking for alcohol advertising, living arrangement and age of onset of regular drinking also influenced trajectory membership. CONCLUSIONS: Quantity and frequency of drinking in adolescence and early adulthood had different trajectories. Membership of heavier drinking groups was affected by environmental influences which are subject to policy change, particularly that of earlier access to licensed premises. In a small group high-quantity consumption did not decrease at age 26.
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How many children remain fracture-free during growth? A longitudinal study of children and adolescents participating in the Dunedin Multidisciplinary Health and Development Study | 2002
Jones, I.E., Williams, S.M., Dow, ... Show all » N., Goulding, A. « Hide
Osteoporosis International, 2002, 13(13), 990-995.
www.ncbi.nlm.nih.gov/pubmed/12459942
Our ref: RO429
Show abstract » While much is known regarding the incidence and pattern of fractures during growth, information is sparse as to how many children fracture repeatedly and how many remain fracture-free during growth. The Dunedin Multidisciplinary Health and Development Study, a birth cohort, whose members were questioned regularly throughout growth (at ages 5, 7, 9, 11, 13, 15 and 18 years) concerning injuries including fractures, has provided a unique opportunity to answer these questions. Life-table analysis showed that approximately half the children remained fracture- free throughout growth [girls 60.1%, (95% CI 54.7-65.0) and boys 49.3% (95% CI 44.0-54.4)]. Data on fracture history, for participants seen at every phase, was available for 601 members through to the age of 18 years (61.1% of the cohort seen at age 5 years). Two hundred and ninety- one of these 601 participants reported 498 fractures, with 172 sustaining a single fracture, and 119 more than one fracture (15.8% girls and 23.4% boys). The most common site of fracture was the wrist/forearm (24.1% of all fractures). We conclude that although bone fractures are a common adverse event in childhood, half of all children remain fracture-free throughout growth.
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Association between children's experience of socioeconomic disadvantage and adult health: a life-course study | 2002
Poulton, R., Caspi, A., Milne, ... Show all » B.J., Thomson, W.M., Taylor, A., Sears, M.R., Moffitt, T.E. « Hide
Lancet, 2002, 360(360), 1640-1645.
Our ref: RO428
Show abstract » Background: Research into social inequalities in health has tended to focus on low socioeconomic status in adulthood. We aimed to test the hypothesis that children's experience of socioeconomic disadvantage is associated with a wide range of health risk factors and outcomes in adult life. Methods: We studied an unselected cohort of 1000 children (born in New Zealand during 1972-73) who had been assessed at birth and ages 3, 5, 7, 9, 11, 13, and 15 years. At age 26 years, we assessed these individuals for health outcomes including body-mass index, waist:hip ratio, blood pressure, cardiorespiratory fitness, dental caries, plaque scores, gingival bleeding, periodontal disease, major depression, and tobacco and alcohol dependence, and tested for associations between these variables and childhood and adult socioeconomic status. Findings: Compared with those from high socioeconomic status backgrounds, children who grew up in low socioeconomic status families had poorer cardiovascular health. Significant differences were also found on all dental health measures, with a threefold increase in adult periodontal disease (31.1% vs 11.9%) and caries level (32.2% vs 9.9%) in low versus high childhood socioeconomic status groups. Substance abuse resulting in clinical dependence was related in a similar way to childhood socioeconomic status (eg, 21.5% vs 12.1% for adult alcohol dependence). The longitudinal associations could not be attributed to life-course continuity of low socioeconomic status, and upward mobility did not mitigate or reverse the adverse effects of low childhood socioeconomic status on adult health. Interpretation: Protecting children against the effects of socioeconomic adversity could reduce the burden of disease experienced by adults. These findings provide strong impetus for policy makers, practitioners, and researchers to direct energy and resources towards childhood as a way of improving population health.
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Cannabis use in adolescence and risk for adult psychosis: longitudinal prospective study | 2002
Arseneault, L., Cannon, M., Poulton, ... Show all » R., Murray, R. M., Caspi, A., Moffitt, T.E. « Hide
BMJ, 2002, 325(325), 1212-1213.
download pdf Our ref: RO427
Show abstract » The strongest evidence that cannabis use may be a risk factor for later psychosis comes from a Swedish cohort study which found that heavy cannabis use at age 18 increased the risk of later schizophrenia sixfold. This study could not establish whether adolescent cannabis use was a consequence of pre-existing psychotic symptoms rather than a cause. We present the first prospective longitudinal study of adolescent cannabis use as a risk factor for adult schizophreniform disorder, taking into account childhood psychotic symptoms antedating cannabis use.
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Orthodontic treatment outcomes in the long term: findings from a longitudinal study of New Zealanders | 2002
Thomson, W.M.
Angle Orthodontist, 2002, 72(72), 449-455.
Our ref: RO426
Show abstract » The aim of this study was to use a health services research (HSR) approach to examine the longer-term outcomes of orthodontic treatment. Participants in a longstanding population-based New Zealand cohort study (the Dunedin Multidisciplinary Health and Development Study) were allocated to one of four malocclusion severity categories on the basis of orthodontic data collected at age 12. The outcome of that care by age 26 was evaluated using the key indicators of equity (was it fair?); efficacy (did it work?); effectiveness (did it work in the longer term?); and safety (was it associated with a greater subsequent experience of caries, periodontal disease, or tooth loss?). Data were available for 452 Study members, of whom 56.2% were in the minor/none category, 29.0% were in the definite category, 10.2% were in the severe category, and 4.6% were in the handicapping treatment-need category. No clear differences in treatment uptake by socioeconomic status were apparent, and the proportion treated increased across the malocclusion severity categories, as did the proportion that showed an improvement following treatment. By age 26 a difference between those who had and those who had not been treated was evident, with the percentage of those rating their dental appearance as above average increasing with increasing severity of the age-12 orthodontic treatment need. This was also true for the percentage that considered their orthodontic treatment to have been successful. There were no significant differences in caries experience, periodontal disease occurrence, or tooth loss between those who had and had not been treated by age 26. This study has found the equity, efficacy, effectiveness, and safety of orthodontic treatment in the Dunedin cohort to be acceptable.
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Partial- or full-mouth approaches to assessing the prevalence of and risk factors for periodontal disease in young adults | 2002
Thomson, W.M., Williams, S.M.
Journal of Periodontology, 2002, 73(73), 1010-1014.
Our ref: RO425
Show abstract » BACKGROUND: While partial-mouth recording is often used in epidemiological studies of periodontal disease because of the efficiencies afforded in data collection, there has been no investigation of the extent to which information is lost in studies of young adults using the combined attachment loss (CAL) approach. METHODS: A random sample of 25- and 26-year-olds was periodontally examined at 3 sites per tooth in all 4 quadrants. The analysis obtained full-mouth prevalence estimates for gingival recession (GR), probing depth (PD), and CAL. The half-mouth analyses took 3 forms: 1) estimates from each of the left and right sides were obtained and compared; 2) estimates were obtained separately and compared for quadrants 1 and 3 (upper right and lower left), and quadrants 2 and 4 (upper left and lower right); and 3) estimates were obtained from a diagonal half-mouth count, whereby quadrants 1 and 3 were analyzed for study participants whose identification number was odd, and quadrants 2 and 4 were analyzed for the remainder. The utility of the half-mouth and full- mouth approaches in analytical epidemiology was examined by estimating the strength of the association between periodontitis prevalence and smoking, male gender, and episodic use of dental care. RESULTS: Of the 169 participants examined, 100 (59.2%) were female, 54 (32.0%) were smokers, and 78 (46.2%) were episodic dental visitors. The difference in prevalence estimates obtained from the different methods was considerably greater for GR than for PD and CAL. The unadjusted odds ratio (OR) for the prevalence of 1 or more teeth with > or = mm of CAL among smokers was 2.3 (95% confidence interval [CI] 1.0, 5.3) using the full data set and 2.4 (95% CI 0.9, 6.1) using the diagonal half-mouth approach. Similarly close odds ratios were observed for males and, to a lesser extent, for episodic dental visitors. CONCLUSIONS: Wherever possible, full-mouth data should be collected for descriptive epidemiological studies of periodontal disease, but where resource and time constraints mean that half-mouth examinations must be used, analytical studies of periodontitis should not be unduly affected by the loss of information. However, where the primary focus of the latter is upon gingival recession, the full-mouth design should be used in order to capture all relevant information, and attention should be directed to making economies in other areas of the data collection process.
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Outcome in adulthood of asymptomatic airway hyperresponsiveness in childhood: a longitudinal population study | 2002
Rasmussen, F., Taylor, D.R., Flannery, ... Show all » E.M., Cowan, J.O., Greene, J.M., Herbison, G.P., Sears, M.R. « Hide
Pediatric Pulmonology, 2002, 34(34), 164-171.
Our ref: RO424
Show abstract » The clinical outcome of asymptomatic airway hyperresponsiveness (AHR) first detected in childhood is sparsely reported, with conflicting results. We used a birth cohort of 1,037 children followed to age 26 years to assess the clinical outcome of asymptomatic AHR to methacholine first documented in study members at age 9 years.Of 547 study members who denied wheezing symptoms ever at age 9 years, 41 (7.5%) showed AHR. Forty showed methacholine responsiveness, with a provocation concentration of methacholine that elicted a 20% drop in forced expired volume in 1 sec (PC(20))
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Risk factors for hospital admission for asthma from childhood to young adulthood: a longitudinal population study | 2002
Rasmussen, F., Taylor, D.R., Flannery, ... Show all » E.M., Cowan, J.O., Greene, J.M., Herbison, G.P., Sears, M.R. « Hide
Journal of Allergy and Clinical Immunology, 2002, 110(110), 220-227.
Our ref: RO423
Show abstract » BACKGROUND: Predictors of hospital admissions for asthma in children and young adults in a general population are not well defined, because most studies have used selected subpopulations. OBJECTIVE: The purpose of this investigation was to determine risk factors for single and multiple hospital admissions for asthma. METHODS: The members of a population-based, unselected birth cohort of 1037 New Zealanders answered questionnaires and underwent lung function, airway responsiveness, and allergy testing on 7 occasions to the age of 26 years. RESULTS: Among the 766 study members (74% of the cohort) who reported wheezing symptoms ever by the age of 26 years, 136 hospitalizations were reported by 62 individuals (8.3% of those at risk, 6.2% of the total cohort). Only 55 of these 136 admissions involved children less than 9 years of age; admissions continued to occur between the ages of 9 and 18 years (40 admissions) and at >18 years (41 admissions). Those admitted were predominantly male, had earlier ages of onset of symptoms, were more atopic, and had more airway hyperresponsiveness to methacholine than those not admitted. Frequent symptoms and low lung function were evident among the 45 study members with single admissions and even more evident among the 17 study members with multiple (2-10) admissions. CONCLUSIONS: A surprisingly large fraction of this unselected population experienced hospitalization for asthma during the 26-year follow-up, many being admitted in later childhood, adolescence, and early adulthood. Clinical characteristics and markers of severity, including frequent respiratory symptoms, airway hyperresponsiveness, atopy, and low lung function, identify those at high risk for hospitalization for asthma, particularly with respect to multiple admissions.
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The burden of illness associated with headache disorders among young adults in a representative cohort study | 2002
Waldie, K.E., Poulton, R.
Headache, 2002, 42(42), 612-619.
Our ref: RO422
Show abstract » This study investigated the functional impairment (work and social functioning and general health status) associated with migraine and tension-type headache (TTH) among young adult members of the Dunedin Multidisciplinary Health and Development Study. Using criteria based on the International Headache Society classificatory system, the 1-year prevalence for migraine headache was 7.4%, TTH was 11.1%, and combined headache (coexisting migraine and TTH) was 4.3%. All comparisons were against a health control group (headache free) and a diagnostic control group (individuals without headache currently using medication for asthma). Although those suffering from migraine and combined headache had the most severe impairment in work- and social-related activities, those with TTH reported significantly poorer social and mental health functioning and poorer emotional and physical functioning while performing everyday roles than did headache-free controls. Study members with combined headache had the poorest self-reported health, with significantly lower ratings on physical, vitality, and mental health measures than asthmatics currently using medication. The pervasive impairment reported across multiple life domains among young headache sufferers illustrates the significant burden of illness associated with headache disorders.
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Migraine and cognitive function: a life-course study | 2002
Waldie, K.E., Hausmann, M., Milne, ... Show all » B.J., Poulton, R. « Hide
Neurology, 2002, 59(59), 904-908.
Our ref: RO421
Show abstract » OBJECTIVE: To investigate the association between migraine and cognitive ability among members of a longitudinal birth cohort study. METHODS: Headache status was determined at age 26 (migraine, tension- type headache [TTH], headache-free control subjects) according to International Headache Society criteria, and data relating to cognitive and academic performance from ages 3 to 26 years were analyzed. RESULTS: Study members diagnosed with migraine were subtly but significantly impaired, compared with those with TTH and headache-free control subjects, on tests of verbal ability (especially language reception) from ages 3 to 13, independent of headache history. Performance on other tasks, including reading, arithmetic, motor, and spatial ability, was normal. The association between migraine and verbal functioning also appeared to impact on later academic success. CONCLUSION: Findings suggest that the poorer verbal performance was unlikely to have resulted from cumulative attacks and may be due to developmental factors beginning in utero.
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Long-term relation between breast-feeding and development of atopy and asthma in children and young adults: a longitudinal study | 2002
Sears, M.R., Greene, J.M., Willan, ... Show all » A., Taylor, D.R., Flannery, E.M., Cowan, J.O., Herbison, G.P., Poulton, R. « Hide
Lancet, 2002, 360(360), 901-07.
Our ref: RO420
Show abstract » Background: Breastfeeding is widely advocated to reduce risk of atopy and asthma, but the evidence for such an effect is conflicting. We aimed to assess long-term outcomes of asthma and atopy related to breastfeeding in a New Zealand birth cohort. Methods: Our cohort consisted of 1037 of 1139 children born in Dunedin, New Zealand, between April, 1972, and March, 1973, and residing in Otago province at age 3 years. Children were assessed every 2-5 years from ages 9 to 26 years with respiratory questionnaires, pulmonary function, bronchial challenge, and allergy skin tests. History of breastfeeding had been independently recorded in early childhood. Findings: 504 (49%) of 1037 eligible children were breastfed (4 weeks or longer) and 533 (51%) were not. More children who were breastfed were atopic at all ages from 13 to 21 years to cats (p=00001), house dust mites (p=00010), and grass pollen (p<00001) than those who were not. More children who were breastfed reported current asthma at each assessment between age 9 (p=00008) and 26 years (p=00008) than those who were not. Breastfeeding effects were not affected by parental history of hayfever or asthma. Multifactor analysis controlling for socioeconomic status, parental smoking, birth order, and use of sheepskin bedding in infancy, showed odds ratios of 194 (95% CI 142-265, p<00001) for any allergen positive at age 13 years, 240 (136-426, p=00003) for current asthma at 9 years, and 183 (135-247, p<00001) for current asthma at 9-26 years by repeated-measures analysis. Interpretation: Breastfeeding does not protect children against atopy and asthma and may even increase the risk.
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Low fear in childhood is associated with sporting prowess in adolescence and young adulthood | 2002
Poulton, R., Milne, B.J.
Behaviour Research and Therapy, 2002, 40(40), 1191-1197.
Our ref: RO419
Show abstract » This study sought to establish if low levels of childhood fear were associated with high level sports performance in adolescence and young adulthood. Parent and teacher reports of fearfulness at ages 5, 7, 9 and 11 and self-reports of sporting achievements at age 26 were obtained for members of the longitudinal Dunedin Multidisciplinary Health and Development Study. Findings indicated a dose-response relation between levels of childhood fear and later sports achievement such that low levels of fear were associated with the greatest likelihood of playing representative sport. Low levels of fear early in life may be associated with elite sports performance in adulthood.
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